Oti-Kéran-Mandouri (OKM) is a complex of protected areas with national and international ecological importance. It is located in the flood plain of the Oti River in Togo. Unfortunately, this area is under anthropogenic pressure. In order to enhance biodiversity conservation, this study aims to assess the spatial changes in land cover within OKM. Landsat images from different missions spanning the time steps 1987, 2000 and 2013 were used to produce land cover maps involving six classes. The classification was based on the maximum likelihood algorithm and the change analyses were performed using Land Change Modeler software integrated in Idrisi GIS and Image Processing system. 3 management system and increasing anthropogenic pressures. These are intensified by climate change since adaptive strategies, such as recessional agriculture, play an important role in land cover change. The ongoing process of rehabilitation should be strengthened to enable this protected area to play its roles as Ramsar site, biosphere reserve and priority corridor for the migration of the West African savannah elephant. Data from this study could be used to guide conservation planning, further landscape pattern assessment and land cover modelling in the framework of climate change.