Worldwide use of HPV self-sampling for cervical cancer screening

Serrano, Beatriz; Ibáñéz, Raquel Sanchez; Robles, Claudia; Peremiquel-Trillas, Paula; Sanjosé, Sílvia de; Bruni, Laia

doi:10.1016/j.ypmed.2021.106900

Cited by 150 publications

(139 citation statements)

References 18 publications

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“…A recent meta-analysis reported that those who received a culturally tailored education (i.e., using lay health workers as instructors, culturally sensitive programs and materials, using cancer survivors) showed a 54% increase in cervical cancer screening adherence [ 30 ]. Also, vaginal self-sampling based on self-collection has recently been introduced as an alternative Pap smear, especially among non-adherent or under-attending women [ 31 , 32 , 33 ], which could be effective for unmarried young adult women who are reluctant to visit obstetrics and gynecology due to social stigma. Therefore, we suggest that culturally customized interventions addressing barriers of unmarried young adult women within the sociocultural context of Korea could help get them to undertake the screening.…”

Section: Discussionmentioning

confidence: 99%

Association of Late Marriage and Low Childbirth with Cervical Cancer Screening among Korean Women: Results from a Nationwide Survey

Shin

Park

Choi

et al. 2022

Cancers

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This study aimed to identify the association of marriage and childbirth with the adherence to cervical cancer screening among young adult women. Data across four years (2017–2020) of the cross-sectional Korean National Cancer Screening Survey were used. For measuring the adherence to cervical cancer screening, we used the cervical cancer screening rate with recommendation, which was defined as the percentage of women in the population eligible for screening who have had a cervical cancer screening within the past two years. Multiple logistic regression analysis was conducted to identify the association between marriage and adherence to cervical cancer screening. Overall, 3925 women aged 20–39 years were analyzed. Of these, 39.1% were screened for cervical cancer (26.6% unmarried and 57.1% married women). The married women had significantly higher adherence to cervical cancer screening than unmarried women (adjusted odds ratio = 2.80, 95% CI: 2.99–3.44). Compared with unmarried women, adherence to cervical cancer screening was significantly more likely to increase (p for trend, <0.001) in married women with an increased number of births. Our study confirmed that marriage and childbirth influence adherence to cervical cancer screening, suggesting that unmarried women may be vulnerable to cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Association of Late Marriage and Low Childbirth with Cervical Cancer Screening among Korean Women: Results from a Nationwide Survey

Shin

Park

Choi

et al. 2022

Cancers

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“…Additionally, due to lack of coordination, the CC screening process in most LIMICs is sometimes considered an “opportunistic screening”, where a Pap test and VIA are requested for patients in clinics and hospitals either as part of general medical examination or for consultations related to or unrelated to CC [ 15 , 16 ]. The overall CC screening rate in LMICs is around 27%, which is very low [ 14 , 15 , 16 ]. The available screening participation rates in Ghana is 2.7% [ 17 ], in Kenya it is between 14% [ 18 ] and 17.5% [ 19 ], in Ukraine it is 30% [ 20 ], and in Nigeria it is 9.4% [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, HPV self-collection is convenient, increases women’s sense of privacy, improves access in remote areas, decreases stigma and embarrassment, and reduces the potential financial (cost of self-sampling vs. the cost of clinician sampling) and logistical burden (i.e., cost of transportation and child care while attending clinician screening) for the patient [ 28 ]. Since the introduction of self-sampling methods, 11 LMICs have included self-sampling in their official programs [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

HPV Self-Sampling for Cervical Cancer Screening among Women Living with HIV in Low- and Middle-Income Countries: What Do We Know and What Can Be Done?

et al. 2022

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Introduction. Self-sampling has the potential to increase cervical cancer (CC) screening among women with HIV in low- and middle-income countries (LMICs). However, our understanding of how HPV self-collection studies have been conducted in women with HIV is limited. The purpose of this scoping review was to examine the extent to which the HPV self-sampling has been applied among women with HIV in LMICs. Method: We conducted multiple searches in several databases for articles published between 2000 and January 2022. With the combination of keywords relating to HPV self-sampling, LMICs, and women with HIV, we retrieved over 9000 articles. We used pre-defined inclusion and exclusion criteria to select relevant studies for this review. Once a study met the inclusion criteria, we created a table to extract each study’s characteristics and classified them under common themes. We used a qualitative descriptive approach to summarize the scoping results. Results: A total of 12 articles were included in the final review. Overall, 3178 women were enrolled in those studies and 2105 (66%) of them were women with HIV. The self-sampling participation rate was 92.6%. The findings of our study show that 43% of the women with HIV in 8 of the studies reviewed tested positive for high-risk HPV (hr-HPV) genotypes, indicating 4 out of 10 women with HIV in the studies are at risk of cervical cancer. The prevalence of the hr-HPV in women with HIV was 18% higher than that of HIV-negative women. Most women in the study found the self-sampling experience acceptable, easy to use, convenient, and comfortable. Self-sampling performance in detecting hr-HPV genotypes is comparable to clinician-performed sampling. However, limited access (i.e., affordability, availability, transportation), limited knowledge about self-screening, doubts about the credibility of self-sampling results, and stigma remain barriers to the wide acceptance and implementation of self-sampling. In conclusion, the findings of this review highlight that (a) the prevalence of hr-HPV is higher among women with HIV than HIV-negative women, (b) self-sampling laboratory performance is similar to clinician-performed sampling, (c) the majority of the women participated in self-sampling, which could likely increase the cervical cancer screening uptake, and (d) women with HIV reported a positive experience with self-sampling. However, personal, environmental, and structural barriers challenge the application of self-sampling in LMICs, and these need to be addressed.

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“…Furthermore, more practical and feasible HPV and cervical screening strategies should be developed during the pandemic. Recent studies suggested that collecting cervical cancer screening samples at home and mailing them to the hospital for further testing can be an effective method for HPV and cervical cytology screening during the pandemic ( 20 , 21 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 Outbreak on the Gynecological Outpatients HPV Infection Rate in Wuhan, China: A Retrospective Observational Study

Liu

et al. 2022

Front. Med.

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BackgroundThe recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak has caused millions of deaths and greatly influenced the timely diagnosis and treatment of other diseases. Throughout the pandemic, there was a dramatic reduction in the prevalence of several sexually transmitted infections. However, the impact of the ongoing pandemic on human papillomavirus (HPV) infection rates has not been investigated thus far.Materials and MethodsWe retrospectively collected data regarding HPV and cervical cancer screening results of outpatients from gynecological clinics of a tertiary hospital from 1 December 2018 to 31 December 2020 in Wuhan. Based on the timeline of the SARS-CoV-2 pandemic in Wuhan, we divided this period into four relatively independent stages to compare the HPV screening visit numbers and infection rates.ResultsThere was a 50% drop in HPV screening visits and a 10% drop in HPV infection rates throughout the pandemic when compared with the numbers collected before the pandemic. Strict lockdown measures greatly decreased the HPV infection rate (17.03 vs. 8.29, P = 0.003). During the pandemic, the most prevalent HPV genotypes were HPV 16, 52, 58, and 53. After the pandemic, the HPV infection rate recovered quickly, but it was still slightly lower than the infection rate found before the outbreak (23.3 vs. 21.2%).ConclusionDuring coronavirus disease 2019 (COVID-19) pandemic, cervical cancer screening visits and HPV infection rates have decreased dramatically. The HPV transmission has also decreased after strict lockdown. Effective HPV and cervical cancer screening programs should be strengthened immediately to reduce the transmission of HPV during and after the pandemic.

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Worldwide use of HPV self-sampling for cervical cancer screening

Cited by 150 publications

References 18 publications

Association of Late Marriage and Low Childbirth with Cervical Cancer Screening among Korean Women: Results from a Nationwide Survey

Association of Late Marriage and Low Childbirth with Cervical Cancer Screening among Korean Women: Results from a Nationwide Survey

HPV Self-Sampling for Cervical Cancer Screening among Women Living with HIV in Low- and Middle-Income Countries: What Do We Know and What Can Be Done?

Impact of COVID-19 Outbreak on the Gynecological Outpatients HPV Infection Rate in Wuhan, China: A Retrospective Observational Study

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