Wound Healing Accelerated by Staphylococcus aureus

Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings

“…69 In some instances, colonization may actually hasten wound healing by increasing wound bed perfusion. 70,71 At the point of critical colonization, however, host defenses can no longer maintain this balance and the wound may enter a nonhealing, chronic inflammatory state. 69 Bacterial loads in excess of 10 5 organisms per gram of tissue are said to impede wound healing, though the status of the host immune system and the number and types of bacterial species present may alter this threshold.…”

Compound 48/80 and the healing of wounds in rats. The effect of timing of drug injections

“…This is noteworthy because of the prevailing view that normal physiologic wound healing cannot be accelerated [5]. The possibility of faster wound healing found support in the work of OLOUMZ et al [6], and LEVENSON and his group [7,8], who reported that infected wounds were stronger. LEVENSON et al [8] also quote the work of Alexis Carrell from over 50 years ago, in which a similar observation was reported.…”

“…The possibility of faster wound healing found support in the work of OLOUMZ et al [6], and LEVENSON and his group [7,8], who reported that infected wounds were stronger. LEVENSON et al [8] also quote the work of Alexis Carrell from over 50 years ago, in which a similar observation was reported. They discuss the possibilities, why this should be so, but do not raise the question of local histamine production due to inflammatory reaction.…”

Inflammatory Reaction and Blood Flow in Experimental Wounds Inoculated with <i>Staphylococcus aureus</i>

“…Botsford [2] treated skin wounds in guinea pigs with a culture of Staphylococcus albus and found that a mild infection exerted a favorable effect on the rate of gain in the wound tensile strength. In the work of Levenson et al [10] 102 S. aureus bacteria introduced into the skin incision of rats significantly accelerated the rate of gain in breaking strength, but this effect was not as great as when 109 organisms Table 1. Effects of various sizes of S. aureus inoculum on blood flow and albumin extravasation in granu lation tissue and different skin sites in the rat…”

“…Several reports indicate that wound heal ing can be accelerated to a certain extent by inoculation with live pathogenic microor ganisms [2,4,10,17,18,21], In a previous study [9], inoculation of experimental wounds, i.e. subcutaneously implanted cellu lose sponges with 102 Staphylococcus aureus organisms enhanced the tissue ingrowth and formation of collagen when studied 14 days after implantation.…”