Wound healing and antioxidant properties: do they coexist in plants?

Süntar, İpek; Akkol, Esra Küpeli; Nahar, Lutfun; Sarker, Satyajit D.

doi:10.5530/ax.2012.2.2.1

Cited by 151 publications

(125 citation statements)

References 33 publications

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“…In general, plant products are largely preferred because of their widespread availability, fewer side effects, and effectiveness as crude preparations (Agyare et al, 2009). The use of plant extracts or plant-derived compounds in the treatment and management of cutaneous wounds can, in most cases, be associated with effective antioxidant and antimicrobial properties (Annan & Houghton, 2008;Süntar et al, 2012;Thakur et al, 2011). Phytochemical screening assay is considered a simple, quick, and inexpensive procedure that is often used to characterize various types of secondary metabolites found in plants (Sasidharan et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Leaf extract of S. vulgaris exhibited an expressive amount of phenolic compounds and a moderate concentration of total flavonoids. Phytochemical constituents of a plant are often correlated to and determine the physiological action on the human body, and phenolic compounds are well-known molecules that have many biological properties, including antioxidant activity, that play an important role in wound healing by preventing and protecting oxidative damage from free radicals (Agyare et al, 2013;Fitzmaurice et al, 2011;Süntar et al, 2012). Using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, which is a widely used technique for measuring the antioxidant activity of plant extracts due to its low cost and accuracy, and the fact that it is easy to perform (Alam et al, 2013), the leaf and branch extracts showed strong antioxidant activity, confirming their antiradical properties.…”

Section: Discussionmentioning

confidence: 99%

“…ROS is produced in high amounts at the wound site, as a defense mechanism against invading bacteria (Süntar et al, 2012). However, at the same time, the presence of increased numbers of neutrophils and ROS in high concentrations can induce severe tissue damage and even lead to neoplastic transformation, decreasing the healing process due to damage to the cellular membranes, DNA, proteins, and lipids.…”

Section: Introductionmentioning

confidence: 99%

“…Given that antioxidant and antimicrobial activities have been found to have positive effects on wound healing (Adetutu et al, 2011;Annan & Houghton, 2008;Srinivas et al, 2008;Süntar et al, 2012), while fibroblast migration and proliferation play a crucial role in the healing process by initiating the proliferative phase of repair (Ebeling et al, 2014;Fronza et al, 2009;Mensah et al, 2001), our study aimed to evaluate the antioxidant, antimicrobial, and woundhealing activities of S. vulgaris.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, antimicrobial and wound healing properties ofStruthanthus vulgaris

Vittorazzi

Endringer

Andrade

et al. 2015

Pharmaceutical Biology

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Context: Struthanthus vulgaris (Vell.) Mart. (Loranthaceae) has been widely used in traditional medicine in Brazil to bathe wounds. Objective: The objective of this study is to investigate the in vitro wound healing effects, together with the antioxidant and antimicrobial activities of S. vulgaris leaf and branch extracts. Material and methods: Ethanol leaf and branch extracts of S. vulgaris were investigated at 1-100 mg/ml concentrations in the scratch assay after 14 h. Antioxidant activity was investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay, and the antibacterial activity was tested at concentrations up to 1000 mg/ml against Gram-positive and Gramnegative bacteria by the microdilution test after 24 h. The total phenolic and flavonoid contents were determined by colorimetric methods. Results: Struthanthus vulgaris leaf and branch extracts at 100 mg/ml concentration stimulated migration and proliferation of fibroblasts and enhanced cell numbers by 56.2% and 18.6%, respectively. Antioxidant activity exhibited IC 50 values of 24.3 and 18.9 mg/ml for the leaf and branch extracts, respectively. The ethanol leaf extract showed antimicrobial activity against the Gram-positive Staphylococcus mutans and Staphylococcus aureus bacteria, exhibiting minimum inhibitory concentration values of 125 and 500 mg/ml, respectively. An appreciable total phenolic content in the leaves (813.6 ± 2.7 mg/g) and branches (462.8 ± 9.6 mg/g), and relatively low concentration of flavonoids in the leaves (13.3 ± 4.3 mg/g) and branches (1.9 ± 0.2 mg/g), was detected. Discussion and conclusion: The antioxidant and antibacterial activities, together with the strong ability to stimulate proliferation and migration of fibroblasts, provide some support for the traditional use of S. vulgaris.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant, antimicrobial and wound healing properties ofStruthanthus vulgaris

Vittorazzi

Endringer

Andrade

et al. 2015

Pharmaceutical Biology

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“…The ROS produced at the wound site if present at high concentrations, can induce severe tissue damage, lead to neoplastic transformation, and even decrease the healing process by damaging the cellular membranes, DNA, proteins, and lipids. 22,23 Antioxidants can interfere with the oxidation process by reacting with free radicals, chelating catalytic metals and by acting as oxygen scavengers. Plants constitute the richest source of natural antioxidants to counteract ROS.…”

Section: Standardized Ethanolic Extract Of C Cainito Leaves As An Anmentioning

confidence: 99%

Wound healing activity of Chrysophyllum cainito L. leaves: Evaluation in rats using excision wound model

Shailajan¹,

Gurjar²

2016

JYP

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Background: The present study was aimed to evaluate the traditionally reported wound healing potential of Chrysophyllum cainito leaves. Methods: The ethanolic extract of C. cainito leaves was standardized in terms of its gallic acid content (a phenolic compound with wound healing properties) using a validated HPTLC technique. The antioxidant activity of C. cainito leaves was also evaluated in vitro. The wound healing potential of the extract was evaluated in male Albino Wistar rats using excision wound model. The results were statistically evaluated and compared with traditional drug Jatyadi Taila (JT) and modern drug Betadine (BTD). Results: Topical application of the standardized ethanolic extract of C. cainito leaves on excision wounds caused the significantly faster reduction in the wound area as compared to JT and BTD. Similarly, it also showed the significant increase in the tissue biochemical parameters such as hydroxyproline, hexosamine and protein when compared with the untreated control. Conclusion: Findings of the present study provide a baseline data on wound healing and antioxidant potential of C. cainito leaves and supports their traditional claim.

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Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor

Eruygur,

Buyukyildirim,

Tetik Rama

et al. 2023

Chemistry & Biodiversity

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Achillea (Asteraceae) species have been traditionally used for their different therapeutical properties. In this study, phytochemical composition of aerial parts of A. sintenisii which is endemic in Turkey was determined with Liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS). To evaluate the wound healing potential, the cream formulation prepared from A. sintenisii was tested on the linear incision wound model in mice. In vitro enzyme inhibitory activity tests were performed on elastase, hyaluronidase, and collagenase. In the histopathological examination, angiogenesis and granulation tissue formation were significantly increased in A. sintenisii treatment groups compared to the negative control group. As a result of this study, it is thought that the enzyme inhibition and antioxidant activity of the plant may contribute to the wound healing process. According to LC/MS/MS analysis result, quinic acid (24.261 μg/mg extract) and chlorogenic acid (14.97 μg/mg extract) were identified as main constituents of the extract.

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Wound healing and antioxidant properties: do they coexist in plants?

Cited by 151 publications

References 33 publications

Antioxidant, antimicrobial and wound healing properties ofStruthanthus vulgaris

Antioxidant, antimicrobial and wound healing properties ofStruthanthus vulgaris

Wound healing activity of Chrysophyllum cainito L. leaves: Evaluation in rats using excision wound model

Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor

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