Wound Healing Applications of Nanomaterials

Şentürk, Berna; Uzunallı, Gözde; Mammadov, Rashad; Güler, Mustafa O.; Tekinay, Ayşe B.

doi:10.1002/9781118987483.ch5

Cited by 3 publications

(7 citation statements)

References 103 publications

(113 reference statements)

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“…In the coming years, smart collagen NPs will be able to engage and guide stem cells to specific body sites and dictate the development of in vivo tissues [98]. Collagen plays a crucial role in biomedicine and it is clear from the facts and discussion in this review that collagen NPs are up and coming materials in drug delivery, formation of tissues, proliferation and attachment of cells [34,99,100].…”

Section: Discussionmentioning

confidence: 99%

Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

et al. 2021

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The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

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Section: Discussionmentioning

confidence: 99%

Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

et al. 2021

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“…In fact, a recent study demonstrated an increase in Ang-1 protein with simultaneous increases of HIF-2α expression in bovine retinal pericytes (BRPs), illustrating synergy between the two expressions in simulating vascularization . As vascularization proceeds with simultaneous completion of ECM production by fibroblasts, fibroblasts undergo differentiation into myofibroblasts …”

Section: Skin Tissue-anatomy Physiology and Healingmentioning

confidence: 99%

“…During this stage, several synchronized processes, such as apoptosis of the fibroblasts, endothelial cells, and macrophages and decreased synthesis of new blood vessels by downregulation of VEGF expression, take place. In addition, synthesis of a new ECM matrix consisting of collagen-type III in the extracellular space takes place. , Simultaneously, the conformation of collagen undergoes transformation into a triple-helix structure. Further transformation takes place by the cleavage of the collagen ends by matrix metalloproteinases (MMPs) secreted by fibroblasts and endothelial cells undergoing apoptosis, thereby achieving tissue homeostasis. , The neo-tissue thus formed undergoes continuous remodeling via cross-linking to achieve texture and mechanical properties closely resembling native tissue …”

Section: Skin Tissue-anatomy Physiology and Healingmentioning

confidence: 99%

“…51 As vascularization proceeds with simultaneous completion of ECM production by fibroblasts, fibroblasts undergo differentiation into myofibroblasts. 52 The final stage of the wound healing process is the remodeling of the formed neo-tissue. During this stage, several synchronized processes, such as apoptosis of the fibroblasts, endothelial cells, and macrophages and decreased synthesis of new blood vessels by downregulation of VEGF expression, take place.…”

Section: Keratinocytes Endothelial Cellsmentioning

confidence: 99%

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Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Kaur

Narayanan

Garg

et al. 2022

ACS Appl. Bio Mater.

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Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue formation, and culminates with tissue remodeling. These four steps significantly overlap with each other and are aided by various factors such as cells, cytokines (both anti- and pro-inflammatory), and growth factors that aid in the neo-tissue formation. In all these stages, advanced biomaterials provide several functional advantages, such as removing wound exudates, providing cover, transporting oxygen to the wound site, and preventing infection from microbes. In addition, advanced biomaterials serve as vehicles to carry proteins/drug molecules/growth factors and/or antimicrobial agents to the target wound site. In this review, we report recent advancements in biomaterials-based regenerative strategies that augment the skin tissue wound healing process. In conjunction with other medical sciences, designing nanoengineered biomaterials is gaining significant attention for providing numerous functionalities to trigger wound repair. In this regard, we highlight the advent of nanomaterial-based constructs for wound healing, especially those that are being evaluated in clinical settings. Herein, we also emphasize the competence and versatility of the three-dimensional (3D) bioprinting technique for advanced wound management. Finally, we discuss the challenges and clinical perspective of various biomaterial-based wound dressings, along with prospective future directions. With regenerative strategies that utilize a cocktail of cell sources, antimicrobial agents, drugs, and/or growth factors, it is expected that significant patient-specific strategies will be developed in the near future, resulting in complete wound healing with no scar tissue formation.

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“…Nanotechnology is also faced with the hindrance of complex pathophysiological expressions with insufficient knowledge in nanoparticle mechanisms of action in the body [122]. Due to the lack of knowledge, nanoparticles may bring on unexpected negative effects such as inflammation and possible toxicity [123]. However, nanotechnology is still an ongoing trend in the scientific research field with a plethora of untapped potential, despite the drawbacks, which aids in the hope that future studies may reduce its disadvantages, fabricating safe and effective nano-based products.…”

Section: Future Perspectivesmentioning

confidence: 99%

Current Update of Collagen Nanomaterials—Fabrication, Characterisation and Its Applications: A Review

Fauzi

2021

Pharmaceutics

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Tissue engineering technology is a promising alternative approach for improvement in health management. Biomaterials play a major role, acting as a provisional bioscaffold for tissue repair and regeneration. Collagen a widely studied natural component largely present in the extracellular matrix (ECM) of the human body. It provides mechanical stability with suitable elasticity and strength to various tissues, including skin, bone, tendon, cornea and others. Even though exogenous collagen is commonly used in bioscaffolds, largely in the medical and pharmaceutical fields, nano collagen is a relatively new material involved in nanotechnology with a plethora of unexplored potential. Nano collagen is a form of collagen reduced to a nanoparticulate size, which has its advantages over the common three-dimensional (3D) collagen design, primarily due to its nano-size contributing to a higher surface area-to-volume ratio, aiding in withstanding large loads with minimal tension. It can be produced through different approaches including the electrospinning technique to produce nano collagen fibres resembling natural ECM. Nano collagen can be applied in various medical fields involving bioscaffold insertion or fillers for wound healing improvement; skin, bone, vascular grafting, nerve tissue and articular cartilage regeneration as well as aiding in drug delivery and incorporation for cosmetic purposes.

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Wound Healing Applications of Nanomaterials

Cited by 3 publications

References 103 publications

Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Current Update of Collagen Nanomaterials—Fabrication, Characterisation and Its Applications: A Review

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