Wound-Healing Effect of Papaya-Based Preparation in Experimental Thermal Trauma

Abstract

Treatment with the phytopreparation from papaya accelerated wound healing and reduced the severity of local inflammation in rats with burn wounds. The effect of this phytopreparation can be related to an increase in the effectiveness of intracellular bacterial killing by tissue phagocytes due to the inhibition of bacterial catalase. Antioxidant activity of the preparation decreases the risk of oxidative damage to tissues.

Effect of Wound Dressing with Fresh Kiwifruit on healing of Cutaneous Wound in Rats

“…Its therapeutical value has been proven in several animal and human trials [13][14][15]. Papain and chymopapain are known to be effective in desloughing necrotic tissue, prevention of infection and the antimicrobial and antioxidant properties related to hydroxyl scavenging and iron chelating properties [15].…”

Investigation of bioactive compounds with anti-cancer potential in Carica papaya leaves

“…The use of various forms of papaya extract for the treatment of different skin diseases has also become widespread with in vitro and in vivo scientific validation (Hewitt et al, 2000, Mikhal'chik et al, 2004, Nayak et al, 2007.…”

“…Another study by Mikhal'chik also showed that the wound healing was accelerated and the severity of local inflammation in rats with burn wounds was reduced (Mikhal'chik et al, 2004).…”

“…Although different parts of the Carica papaya plant have been used as traditional medicine for the treatment of skin infections and wound healing in general, and this widespread use has been scientifically validated (Hewitt et al, 2000, Mikhal'chik et al, 2004, Nayak et al, 2007, no information is available on the activity of this plant on skin cancer. Furthermore, the effects of Carica papaya leaf extracts have previously been reported to have been tested on the growth of different cancer cell lines: breast, stomach, lung, pancreatic, colon, liver, ovarian, cervical, neuroblastoma, lymphoma, leukaemia and other haematological cancers , Otsuki et al, 2010, Rumiyati, 2006; to our knowledge, no skin cancer cell lines have been tested.…”

“…Interestingly, there is some overlap between the geographical distribution of Carica papaya (Food and Agriculture Organization, 2013) and that of UV exposure (Emmanuelle Bournay, 2012). As the widespread use of different parts (leaves, fruits and flowers) of Carica papaya plants for the treatment of skin infections and wound healing has been scientifically validated (Hewitt et al, 2000, Mikhal'chik et al, 2004, Nayak et al, 2007, testing of the effect of papaya leaf preparations on skin cancer is warranted.…”