Wound healing potential of green synthesized silver nanoparticles prepared from Lansium domesticum fruit peel extract

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

“…Complete epithelialization with keratinization as well as fibrous connective tissue proliferation were also the results of administration of nanoparticles. 73 The level of hydroxyproline and total proteins at the initial phase of wound healing was also increased in the presence of biosynthesized AgNPs, which confirmed the effect of these biosynthesized nanoparticles on cellular hyperplasia and deposition of matrix proteins in granulation tissues. 74 The linseed hydrogel was another choice for the green synthesis of AgNPs, possessing the advantages of increasing the wound closure percentage and also the collagen content at the wound site.…”

“…Some of the prominent examples of these plants are Cassia roxburghii, 66 Drosera binata Labill., 67 Indigofera aspalathoides DC., 68 Azadirachta indica A. Juss., 69 Arnebia nobilis Rech.f., 70 Melia dubia Cav., 71 Terminalia chebula Retz., 72 Lansium domesticum Corrêa, 73 Orchidantha chinensis T.L.Wu, 74 A. vera (L.) Burm.f., 75 glucuronoxylan, 76 Momordica charantia L., 77,78 Carica papaya L., 79 Cymbopogon citratus (DC.) Stapf, 80 Nyctanthes arbor-tristis L., 81 Naringi crenulata (Roxb.)…”

“…The other parameter which can be controlled to accelerate the wound healing process is the rate of synthesis of collagen. 73 The first step in synthesis of collagen is hydroxylation of proline to form hydroxyproline. 91 Thus, the hydroxyproline content is a good marker for collagen deposition, which has been determined in several studies on the application of green-synthesized AgNPs.…”

“…The administration of L. domesticum-mediated and linseed-mediated AgNPs to the animals increased the tensile strength of wound due to organization of collagen fibers. 60,73 Guar gum/AgNPs were other phytosynthesized medications possessing significant effect on the tensile strength and modulation of collagen deposition, in addition to regulation of keratinocytes and accelerating the essential re-epithelialization process. 94 In addition to the abovementioned nanostructures, green-synthesized AgNPs can be included into/or coated on the common dressings, electrospun nanofibers, and nanofibrous membranes.…”

Silver nanoparticles as an effective disinfectant: A review

“…In vivo wound healing analysis demonstrated that it intensify wound closure time and excellent histocompatibility. Thus, it has good prospectus in the disinfection applications [49]. Typically, inflammatory skin diseases, with atopic dermatitis, psoriasis, and contact dermatitis are the majorly widespread skin conditions impact on adults and children.…”