Wound-Related Allergic/Irritant Contact Dermatitis

Alavi, Afsáneh; Sibbald, R. Gary; Ladizinski, Barry; Saraiya, Ami; Lee, Kachiu C.; Skotnicki-Grant, Sandy; Maibach, Howard I.

doi:10.1097/01.asw.0000482834.94375.1e

Cited by 34 publications

(20 citation statements)

References 29 publications

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“…For instance, PVA has been used to create hydrogels for wound dressing [ 29 ] or electrospun together with active substances, such as silver nanoparticles [ 30 ], and curcumin [ 31 ], to produce wound dressings. Several wound dressings in the market containing active agents such as hydrocolloids or silver dressings often used on wound healing have shown negative effects such as allergic contact dermatitis [ 32 ], and use of dressings loaded with antibiotics has risk of developing antimicrobial resistance [ 33 ]. Our interest in this study is to develop a dressing loaded with birch bark extract with a sustained drug release that is suitable for human use on wound healing with effective therapy even after long-term usage.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Bioactive Wound Dressing Containing Colloidal Dispersions of Birch Bark Dry Extract

2020

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Novel birch bark dry extract (TE)-loaded polyvinyl alcohol (PVA) fiber mats intended for wound therapy were developed through an electrospinning process. Colloidal dispersions containing TE as the active substance were prepared by the high-pressure homogenization (HPH) technique using hydrogenated phospholipids as stabilizer. Subsequently, the colloidal dispersions were blended with aqueous PVA solutions in the ratio of 60:40 (wt.%) and electrospun to form the nanofiber mats. Fiber morphology examined using scanning electron microscopy (SEM) indicated that fibers were uniform and achieved diameters in the size range of 300–1586 nm. Confocal Raman spectral imaging gave good evidence that triterpenes were encapsulated within the electrospun mats. In vitro drug release and ex vivo permeation studies indicated that the electrospun nanofibers showed a sustained release of betulin, the main component of birch bark dry extract, making the examined dressings highly applicable for several wound care applications. Ex vivo wound healing studies proved that electrospun fiber mats containing TE accelerated wound healing significantly more than TE oleogel, which was comparable to an authorized product that consists of TE and sunflower oil and has proved to enhance wound healing. Therefore, our results conclude that the developed TE-PVA-based dressings show promising potential for wound therapy, an area where effective remedy is needed.

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Section: Introductionmentioning

confidence: 99%

Electrospun Bioactive Wound Dressing Containing Colloidal Dispersions of Birch Bark Dry Extract

2020

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“…This can lead to the development of irritative‐toxic, cumulative‐subtoxic, or contact‐allergic eczema . In a study by Alavi et al, it was shown that the irritative genesis of eczema in patients with chronic wounds is much more frequent (80%) than the contact‐allergic genesis (20%) . In the occurrence of contact‐allergic eczema, besides the widespread ingredients of care products such as fragrances, rosin, potassium dichromate, and also wound therapeutics such as hydrocolloids or hydrogels play a role .…”

Section: Discussionmentioning

confidence: 99%

Pruritus in patients with chronic leg ulcers: A frequent and often neglected problem

Jockenhöfer

Zaremba

Wehrmann³

et al. 2019

International Wound Journal

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There is a paucity of studies regarding pruritus in patients with chronic leg ulcers. Data were collected using newly developed questionnaires for patients and physicians to evaluate pruritus in individuals with chronic leg ulcers. The results show that a total of 50 patients with chronic leg ulcers were included in this prospective study. Frequent pruritus was observed in 32.0% of the participants, while 36.0% reported occasional pruritus. The average pruritus intensity was 3.5 points (0‐10 numeric rating scale [NRS]) and was found to increase with age. Patients experiencing pruritus achieved a higher Wound‐quality of life (QoL) score (32.1) as that of patients without pruritus (25.8). Additional dermatological findings around the wounds included xerosis (26.0%), eczema (4.0%), and excoriations (2.0%). Pruritus was reported by all subjects with eczema and 84.6% of those with xerosis. The pruritus lasted significantly longer in women (average 98.4 months) vs men (average 37.5 months). Interestingly, men reported more intense pruritus than women (4.4 vs 2.8). Females reported more frequent use of skin care products than males. In conclusion, the current data show that two‐thirds of patients with chronic leg ulcers suffer from moderate intense pruritus. Therefore, pruritus is a frequent and often neglected problem that should be regularly evaluated in all patients with chronic leg ulcers and considered in future therapy concepts.

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“…To this end, various topical wound care products are available that provide a moist wound-healing environment, promote autolytic debridement, demonstrate anti-inflammatory activity and/or antimicrobial properties, and thereby promote an improved and rapid healing. 4 As wound healing can be delayed by microbial infection, topical antiseptics and antibiotic agents, including cadexomer and povidone iodine, chlorhexidine, polyhexanide (PHMB), octenidine, silver, and bacitracin, may be present to control microbial colonisation. 2,3,5 To prevent contamination of the dressing itself with mould, fungi, and/or bacteria and to protect consumers against an undesired increase in the risk of infection, preservation of such wound care formulations can be an additional prerequisite.…”

Section: Introductionmentioning

confidence: 99%

“…6 Similar to cosmetics and other personal care products, preservative ingredients, such as urea derivatives (imidazolidinyl and diazolidinyl urea), isothiazolinones (methylisothiazolinone and methylchloroisothiazolinone), halogen-organic actives (iodopropynyl butylcarbamate and methyldibromo glutaronitrile), formaldehyde, Quaternium 15 (ie, formaldehyde-releaser), silver salts, organic acids (potassium sorbate, sodium benzoate), phenoxyethanol (alone or in combination with methyldibromo glutaronitrile), and parabens, can be indispensable. 4,[6][7][8][9] Although the use of antimicrobial and preservative ingredients is, in turn, subjected to certain restrictions in order to safeguard both product and consumer safety, consumer awareness regarding their skin sensitisation potential has increased. Several agents, and paraben preservatives in particular, have been criticised in this regard.…”

Section: Introductionmentioning

confidence: 99%

A perspective on the safety of parabens as preservatives in wound care products

Torfs¹,

Brackman²

2020

International Wound Journal

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Antimicrobial and/or preservative ingredients incorporated in wound care products are subjected to certain safety restrictions. However, several of those agents, and paraben preservatives in particular, have been criticised. Conflicting reports on the potential of parabens to induce allergic contact dermatitis, and their assumed oestrogen-like activity, raised public health concerns about their overall safety. Here, we seek to provide a balanced perspective on the most significant purported adverse health effects, and thereby allay the many misconceptions regarding the safety of parabens. Extensive and long-term monitoring of paraben allergy frequencies illustrate that allergic reactions are quite uncommon, especially when compared with other antimicrobial and preservative agents. The estrogenic potential of parabens was illustrated to be far less potent than that of natural oestrogen receptor ligands, and the etiological significance of their presence in human tissue has not been established. The general consensus based on investigations by both the scientific community and regulatory agencies indicates that, with current safety regulations regarding their use in place, this effective and well-documented group of preservatives should not warrant drastic measures to replace them. As such, despite the ongoing concern, it is indicated that, when used at typical concentrations, parabens are unlikely to affect human health.

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Wound-Related Allergic/Irritant Contact Dermatitis

Cited by 34 publications

References 29 publications

Electrospun Bioactive Wound Dressing Containing Colloidal Dispersions of Birch Bark Dry Extract

Electrospun Bioactive Wound Dressing Containing Colloidal Dispersions of Birch Bark Dry Extract

Pruritus in patients with chronic leg ulcers: A frequent and often neglected problem

A perspective on the safety of parabens as preservatives in wound care products

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