WOX11 recruits a histone H3K27me3 demethylase to promote gene expression during shoot development in rice

Cheng, Saifeng; Tan, Feng; Lu, Yue; Liu, Xiaoyun; Li, Tiantian; Yuan, Wenjia; Zhao, Yu; Zhou, Dao‐Xiu

doi:10.1093/nar/gky017

Cited by 74 publications

(60 citation statements)

References 60 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies had shown that callus could be induced from aerial organs and resembles the tip of a root meristem (Sugimoto et al, 2019). The root meristem regulator genes, such as WOX5 and WOX11, had been verified to play important roles in callus initiation in A. thaliana and Oryza sativa (Hu et al, 2017;Cheng et al, 2018;Liu et al, 2018a;Sang et al, 2018). In this study, ZmWOX11 showed peak expression at D2 and dropped afterward.…”

Section: Discussionsupporting

confidence: 49%

Transcriptome Profiling Predicts New Genes to Promote Maize Callus Formation and Transformation

Fang

Liu

et al. 2019

Front. Plant Sci.

View full text Add to dashboard Cite

Maize transformation is highly based on the formation of embryonic callus, which is mainly derived from scutellum cells of the immature maize embryo. However, only a few genes involved in callus induction have been identified in maize. To reveal the potential genes involved in the callus induction of maize, we carried out a high-throughput RNA sequencing on embryos that were cultured for 0, 1, 2, 4, 6, and 8 days, respectively, on a medium containing or lacking 2,4-dichlorophenoxyacetic acid. In total, 7,525 genes were found to be induced by 2,4-dichlorophenoxyacetic acid and categorized into eight clusters, with clusters 2 and 3 showing an increasing trend related to signal transmission, signal transduction, iron ion binding, and heme binding. Among the induced genes, 659 transcription factors belong to 51 families. An AP2 transcription factors, ZmBBM2, was dramatically and rapidly induced by auxin and further characterization showed that overexpression of ZmBBM2 can promote callus induction and proliferation in three inbred maize lines. Therefore, our comprehensive analyses provide some insight into the early molecular regulations during callus induction and are useful for further identification of the regulators governing callus formation.

show abstract

Section: Discussionsupporting

confidence: 49%

Transcriptome Profiling Predicts New Genes to Promote Maize Callus Formation and Transformation

Fang

Liu

et al. 2019

Front. Plant Sci.

View full text Add to dashboard Cite

show abstract

“…As the contribution of REF6 to DNRR has not yet been tested, it remains unclear whether in ref6 mutant explants, AR formation is unaffected, as suggested by the result of callus formation, or delayed like LR formation in ref6. During rice shoot development, OsWOX11 recruits the REF6 homolog JUMONJI705 (JMJ705) to promote gene expression by H3K27me3 demethylation (Cheng et al, 2018). It would be interesting to test whether WOX11 and REF6 cooperate similarly during regular root development and DNRR in Arabidopsis.…”

Section: Epigenetic Regulation Of Dnrr By the Repressive Mark H3k27me3mentioning

confidence: 99%

Reprogramming of Cell Fate During Root Regeneration by Transcriptional and Epigenetic Networks

Jing

Ardiansyah

et al. 2020

Front. Plant Sci.

View full text Add to dashboard Cite

Many plant species are able to regenerate adventitious roots either directly from aerial organs such as leaves or stems, in particularly after detachment (cutting), or indirectly, from over-proliferating tissue termed callus. In agriculture, this capacity of de novo root formation from cuttings can be used to clonally propagate several important crop plants including cassava, potato, sugar cane, banana and various fruit or timber trees. Direct and indirect de novo root regeneration (DNRR) originates from pluripotent cells of the pericycle tissue, from other root-competent cells or from non-root-competent cells that first dedifferentiate. Independently of their origin, the cells convert into root founder cells, which go through proliferation and differentiation subsequently forming functional root meristems, root primordia and the complete root. Recent studies in the model plants Arabidopsis thaliana and rice have identified several key regulators building in response to the phytohormone auxin transcriptional networks that are involved in both callus formation and DNRR. In both cases, epigenetic regulation seems essential for the dynamic reprogramming of cell fate, which is correlated with local and global changes of the chromatin states that might ensure the correct spatiotemporal expression pattern of the key regulators. Future approaches might investigate in greater detail whether and how the transcriptional key regulators and the writers, erasers, and readers of epigenetic modifications interact to control DNRR.

show abstract

“…33,34 H3K27me3 plays an important role in maintaining gene repression during development in plants, embryonic stem cell and cancer cells. 35,36 Thus, we performed a ChIP experiment to measure H3K27me3 occupancy at TGFBR1 promoter in the HTR-8/SVneo-shNC and HTR-8/SVneo-shDNMT3A cells. Consistent with changes in EZH2 occupancy at TGFBR1 promoter, the level of H3K27me3 was diminished after DNMT3A downregulation ( Figure 4E).…”

Section: Tgfbr1 Is Repressed By Dnmt3a Through the Recruitment Of Ementioning

confidence: 99%

Induction of TGF‐β receptor I expression in a DNA methylation‐independent manner mediated by DNMT3A downregulation is involved in early‐onset severe preeclampsia

et al. 2020

View full text Add to dashboard Cite

Preeclampsia, especially early‐onset severe preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality. Although it has been well known that the pathophysiology of early‐onset severe preeclampsia begins with abnormal placentation and aberrant activation of TGF‐β signaling inhibits trophoblast cell invasion, the mechanisms underlying dysregulation of TGF‐β signaling in early‐onset severe preeclampsia remain elusive to date. Here, we revealed that induction of TGFBR1/TGF‐β signaling mediated by DNMT3A downregulation plays a critical role in early‐onset severe preeclampsia. Our results show that DNMT3A downregulation elevates TGFBR1 expression in trophoblast cells. Moreover, inhibition of TGFBR1 and TGF‐β/Smad signaling can rescue the deficiencies of trophoblast cell migration and invasion caused by DNMT3A knockdown. Mechanistically, DNMT3A suppresses the transcription of TGFBR1 through recruiting EZH2 to its promoter but not changing DNA methylation of TGFBR1 promoter. In human samples, we detected lowly expressed DNMT3A, highly expressed TGFBR1 and hyperactivation of TGF‐β/Smad signaling in decidua‐embedded extravillous trophoblasts in early‐onset severe preeclampsia, which provides the clinical evidence for the correlation between DNMT3A and TGFBR1. Collectively, our findings demonstrate that DNA methylation‐independent induction of TGFBR1 mediated by DNMT3A downregulation is relevant to the development of early‐onset severe preeclampsia.

show abstract

WOX11 recruits a histone H3K27me3 demethylase to promote gene expression during shoot development in rice

Cited by 74 publications

References 60 publications

Transcriptome Profiling Predicts New Genes to Promote Maize Callus Formation and Transformation

Transcriptome Profiling Predicts New Genes to Promote Maize Callus Formation and Transformation

Reprogramming of Cell Fate During Root Regeneration by Transcriptional and Epigenetic Networks

Induction of TGF‐β receptor I expression in a DNA methylation‐independent manner mediated by DNMT3A downregulation is involved in early‐onset severe preeclampsia

Contact Info

Product

Resources

About