X‐ray‐Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery

Abstract

The targeted and sustained drug release from stimuli‐responsive nanodelivery systems is limited by the irreversible and uncontrolled disruption of the currently used nanostructures. Bionic nanocapsules are designed by cross‐linking polythymine and photoisomerized polyazobenzene (PETAzo) with adenine‐modified ZnS (ZnS‐A) nanoparticles (NPs) via nucleobase pairing. The ZnS‐A NPs convert X‐rays into UV radiation that isomerizes the azobenzene groups, which allows controlled diffusion of the active payloads across the bilayer membranes. In addition, the nucleobase pairing interactions between PETAzo and ZnS‐A prevent drug leakage during their in vivo circulation, which not only enhances tumor accumulation but also maintains stability. These nanocapsules with tunable permeability show prolonged retention, remotely controlled drug release, enhanced targeted accumulation, and effective antitumor effects, indicating their potential as an anticancer drug delivery system.

Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy

“…When analyzing the D-Exos/miR21i-L17E, the co-localization ratio of cargos to endosome was relatively low, suggesting that Dox and RNA began to escape from the endosome under L17E triggering. As the incubation time increased, the Dox in both groups gradually entered the nucleus, because small molecules could cross the biological membrane through a passive diffusion mechanism 50 . As cellular uptake time increased, the internalized miR-21i molecules of D-Exos/miR21i treatment group gradually dispersed into cytosol, but were still partially entrapped in endosomes.…”

An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

“…Subsequently, in vivo anti-tumor therapeutic effect of FBC nanogels was studied. When the volume of tumor xenograft in mice reached 100 mm 3 , the mice and FBC-200+L groups were treated with 750 nm laser irradiation (200 mW/cm 2 ) for 10 min, respectively. In the period of treatment, body weights of the mice and the volumes of the tumors were recorded every three days ( Fig.…”

“…However, the clinical utility of PDT is greatly limited by the inadequate NIR absorption, oxygen dependence and poor stability of conventional photosensitizers (PSs) such as photofin, verteporfin and padeliporfin. The short wavelength light absorbed by PSs cannot reach the deep tissue due to absorption of the skin and subcutaneous adipose tissue, resulting in lower photoconversion, serious tissue damage and the limited clinical application of PDT in deep tumors 3 . To address this issue, some strategies such as two-photon excitation (TPE) technique 4,5 and upconversion nanoparticles (UCNPs) 6,7 had been introduced for the therapy of deep tumors, but the complex equipment and the low conversion efficiency will bring about new problems for the clinic application 8,9 .…”

Oxidative‐Species‐Selective Materials for Diagnostic and Therapeutic Applications

“…[88] Themolecular structure of the related azo dyes has agreat effect on their reactivity towards COH. [89] Forinstance, the ortho isomer of Methyl red showed higher reactive sensitivity to COH than Methyl red and other derivatives because of the formation of internal H-bonding in the ortho Methyl red adduct. Significantly,t he azo bond is specifically broken by COH and not is not affected by other species.Onthe basis of the COH-mediated degradation of azo dyes,s everal luminescent COH nanoprobes have been developed and applied for both in vitro and in vivo detection of COH.…”