2014
DOI: 10.1109/access.2014.2359831
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X-Ray Fluorescence Computed Tomography With Polycapillary Focusing

Abstract: Liposomal iodine nanoparticles (LINPs) have a long half-life and provide an excellent intravascular contrast. The nanoparticles can be functionalized as molecular probes for biological targets to facilitate numerous preclinical studies for translation toward diagnosis and therapy of various human diseases. Iodine has a K-edge at 33 keV due to the photoelectric absorption of photons, which emit X-ray fluorescence at 28 keV with a fluorescence yield of 0.88. Detections of the characteristic X-rays can be used fo… Show more

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Cited by 8 publications
(1 citation statement)
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“…Instead of the focusing optic being used on the excitation side, focusing optics have been used after the sample to collect the fluorescence radiation in conventional, synchrotron beam (87), proton beam (88), and particle-induced X-ray emission (PIXE) (89,90) systems. A similar system has been proposed for imaging nanoparticles in tissue (91). Confocal systems (92), in which one optic focuses the incident beam onto the sample and the second optic selects only emission from that region, provide the double benefit of enhanced signal intensity and three-dimensional spatial resolution.…”
Section: X-ray Fluorescence and Spectrometrymentioning
confidence: 99%
“…Instead of the focusing optic being used on the excitation side, focusing optics have been used after the sample to collect the fluorescence radiation in conventional, synchrotron beam (87), proton beam (88), and particle-induced X-ray emission (PIXE) (89,90) systems. A similar system has been proposed for imaging nanoparticles in tissue (91). Confocal systems (92), in which one optic focuses the incident beam onto the sample and the second optic selects only emission from that region, provide the double benefit of enhanced signal intensity and three-dimensional spatial resolution.…”
Section: X-ray Fluorescence and Spectrometrymentioning
confidence: 99%