X-ray powder diffractometry and liquid chromatography studies of sibutramine and its analogues content in herbal dietary supplements

Stypulkowska, K.; Błażewicz, Agata; Maurin, Jan K.; Sarna, Katarzyna; Fijałek, Zbigniew

doi:10.1016/j.jpba.2011.08.028

Cited by 32 publications

(11 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They have much stronger undesirable effects usually and even cause death (World Health Organisation, 2018). That is why it is important to control their chemical composition, using the available test methods (Stypułkowska et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Application of X-Ray Powder Diffraction for Analysis of Selected Dietary Supplements Containing Magnesium and Calcium

Jendrzejewska

2020

Front. Chem.

View full text Add to dashboard Cite

It is estimated that ∼50% of medications and dietary supplements offered in the Internet are counterfeit. X-ray diffraction is one of the techniques which may be successfully applied to identify various chemical compounds in polycrystalline mixtures such as dietary supplements, but also medications, narcotics or designer drugs. X-ray diffraction enables the understanding of compositions of such mixtures. For the tests, 22 dietary supplements which should contain magnesium and calcium compounds, available in pharmacies, groceries, Internet shops, as well as in shops for sportspersons, were selected. Identification of crystalline substances present in the tested sample consists in determination of inter-planar distances d hkl of investigated substances and determination of intensity of the obtained diffraction lines, and then in comparing them with values contained in diffraction databases. In this study, the ICDD-PDF2 database was used. The most important criterion in qualitative analysis, confirming the presence of a given phase, is the conformity of positions of diffraction lines in the recorded diffraction image with those in the reference image. Reflection shifts for the individual 2θ angles compared with the data from the database should not exceed 0.2 •. In most cases, X-ray analysis of the investigated dietary supplements proved the presence of magnesium and calcium compounds declared by the manufacturer, as well as allowing the identification of auxiliary substances present in the tested products. In the case of two magnesium-containing dietary supplements, the magnesium compounds declared by the manufacturer were not found. Our studies confirmed the effectiveness of X-ray structural analysis and proved the possibility of distinguishing counterfeit preparations from authentic products, as well as to use this method for the quality control of such pharmaceutical preparations.

show abstract

Section: Introductionmentioning

confidence: 99%

Application of X-Ray Powder Diffraction for Analysis of Selected Dietary Supplements Containing Magnesium and Calcium

Jendrzejewska

2020

Front. Chem.

View full text Add to dashboard Cite

show abstract

“…In India, herbal medicines are regulated by the Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy (AYUSH) [7] and guidelines by AYUSH should be followed strictly by manufacturers. From different kinds of literature data, it was found that various techniques have been used till now to detect the presence of the pharmaceutical drug in herbal medicines such as X-ray powder diffractometry, liquid chromatography [8], Nuclear Magnetic Resonance (NMR) [9] and Highperformance thin-layer chromatography (HPTLC) [10]. The study was conducted in India to assess the prevalence of abdominal obesity and generalized obesity among 309 people in the rural area and it was found that combined obesity was 51.3% [11].…”

Section: Introductionmentioning

confidence: 99%

Screening of Adulterants in Slimming Herbal Formulation by FTIR Analysis

Khare¹,

Mishra

Kesharwani

2019

EJMP

View full text Add to dashboard Cite

Herbal formulations are used worldwide during these days specifically as the remedy of some commonly occurring health problems such as diabetes, obesity and digestive disorder. As the use and demand of these herbal formulations have increased, cases of adulteration of herbal formulations with synthetic pharmaceuticals have also increased. The main reason behind the adulteration in herbal formulation with the synthetic drug is to get commercial gain by increasing effectiveness of the herbal formulation. As the use of herbal slimming formulation is on the rise in India due to increasing problem of obesity, therefore, the main aim of the present study is to analyze the herbal slimming formulations present in the Indian market for the presence of synthetic pharmaceuticals by FTIR method. Out of 20 herbal slimming formulations analysed, 7 herbal slimming samples were detected with the presence of synthetic drugs such as Modafinil, Salbutamol, Phenolphthalein and Caffeine. In our study, FTIR has proven an effective method for screening of synthetic pharmaceutical in Herbal formulations.

show abstract

“…The detection processes of TCM ingredients are complicated and challenging. Several methods are used to determine undeclared adulterants in herbal medicine or food supplements, including the following: LC-PDA [ 12 ], GC-MS [ 13 ], GC-QQQMS [ 14 ], LC-MS [ 15 ], LC-MS/MS [ 12 ], UPLC-TOF/MS [ 16 ], Q-Orbitrap MS [ 17 ], NMR [ 18 ], X-ray powder diffractometry [ 19 ], TLC-image [ 20 ], TLC-SERS [ 21 ], ATR‑IR [ 22 ], and CE-MS [ 23 ]. The applicability of GC‑MS is determined by the volatility and thermal stability of analytes.…”

Section: Introductionmentioning

confidence: 99%

Detection of adulterated drugs in traditional Chinese medicine and dietary supplements using hydrogen as a carrier gas

et al. 2018

View full text Add to dashboard Cite

Helium, a minor component of natural gas and radioactive minerals, is most commonly used as a carrier in gas chromatography-mass spectrometry (GC-MS). Its scarcity leads to limited availability and higher costs. In this experiment, hydrogen from a safe source of a hydrogen generator was tested as a substitutive carrier gas for the detection of adulterant in traditional Chinese medicine (TCM) and food supplements by GC-MS analysis. We found that the limits of detection (LODs) of using hydrogen were from 10 to 1000 μg/g. The levels of LODs tested among 170 drugs remain the same whether hydrogen or helium was used as a carrier gas with the exception of 7 drugs—benzbromarone, estradiol benzoate, bezafibrate, mefenamic acid, oxymetholone, piperidenafil and cetilistat. The real sample analysis results using hydrogen were as satisfactory as those using helium. In addition, the retention time was shortened after the chromatographic performance was optimized. In summary, it is worth considering hydrogen as a carrier gas due to its affordable costs, energy efficiency, carbon reduction and chromatographic advantages to detect adulterated drugs in TCM and dietary supplement using GC-MS.

show abstract

X-ray powder diffractometry and liquid chromatography studies of sibutramine and its analogues content in herbal dietary supplements

Cited by 32 publications

References 14 publications

Application of X-Ray Powder Diffraction for Analysis of Selected Dietary Supplements Containing Magnesium and Calcium

Application of X-Ray Powder Diffraction for Analysis of Selected Dietary Supplements Containing Magnesium and Calcium

Screening of Adulterants in Slimming Herbal Formulation by FTIR Analysis

Detection of adulterated drugs in traditional Chinese medicine and dietary supplements using hydrogen as a carrier gas

Contact Info

Product

Resources

About