X-ray structure analysis and vibrational spectra of Furosemide

Bölükbaşı, Olcay; Yılmaz, Ayberk

doi:10.1016/j.vibspec.2012.06.002

Cited by 15 publications

(12 citation statements)

References 16 publications

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Section: Concentration Effects On Sers Signalsmentioning

confidence: 98%

“…Furosemide SERS spectrum shows again relatively intense band at 786 cm −1 (assigned to aromatic bending modes, with some contribution of COO − group [40]), together with additional bands at 880 and 1435 cm −1 . While the first one corresponds to an aromatic bending mode, the second one can be assigned to CH 2 bending in the aliphatic chain [40]. Also in this case, the absence of SO 2 stretching and NH 2 bending bands (both present in furosemide powder spectrum, respectively at 1148 and 1072 cm −1 , Figure S4) suggests that the binding occurs through the alkyl-amino group.…”

Section: Concentration Effects On Sers Signalsmentioning

confidence: 98%

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Multilayer Gold-Silver Bimetallic Nanostructures to Enhance SERS Detection of Drugs

et al. 2020

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Surface-enhanced Raman scattering (SERS) is a widely used technique for drug detection due to high sensitivity and molecular specificity. The applicability and selectivity of SERS in the detection of specific drug molecules can be improved by gathering information on the specific interactions occurring between the molecule and the metal surface. In this work, multilayer gold-silver bimetallic nanorods (Au@Ag@AuNRs) have been prepared and used as platforms for SERS detection of specific drugs (namely promethazine, piroxicam, furosemide and diclofenac). The analysis of SERS spectra provided accurate information on the molecular location upon binding and gave some insight into molecule-surface interactions and selectivity in drug detection through SERS.

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Section: Concentration Effects On Sers Signalsmentioning

confidence: 98%

Section: Concentration Effects On Sers Signalsmentioning

confidence: 98%

Multilayer Gold-Silver Bimetallic Nanostructures to Enhance SERS Detection of Drugs

et al. 2020

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“…[21][22] For Furosemide, the chosen marker band is the in-plane ring bending vibration at 686 cm -1 . 39 For PVP, the selected marker band is the most intense CH2 asymmetric stretching vibrations of the saturated PVP chains peak at 2924 cm -1 . 40 The far-field Raman spectra and the marker bands of pure the number of molecules localized in the enhanced field areas, Raman intensities in SERS spectra exceed the intensities of far-field spectra by factor between 80 and 200.…”

Section: Structure and Morphology Analysis Of Furosemide/pvp Particlesmentioning

confidence: 99%

Formation Mechanism of Sub-Micron Pharmaceutical Composite Particles derived from Far- and Near Field Raman microscopy

Hübner¹,

Coty²,

Busby³

et al. 2020

Preprint

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<a>Surface-enhanced Raman spectroscopy (SERS) and confocal Raman microscopy are applied to investigate the structure and the molecular arrangement of a sub-micron pharmaceutical organic composite. As a model system, sub-micron Furosemide and polyvinylpyrrolidone (Furosemide/PVP) particles produced by spray flash evaporation (SFE) from a single solution are investigated. The morphology, size and crystallinity of Furosemide/PVP composites are first analyzed by scanning electron microscopy (SEM) and X-ray powder diffraction (XRPD). Afterwards, reference far-field Raman spectra and confocal far-field Raman maps of Furosemide/PVP particles are interpreted based on the far-field Raman spectra of pure Furosemide and pure PVP precursors. Confocal far-field Raman microscopy shows that Furosemide/PVP particles feature an intermixture of Furosemide and PVP molecules at the sub-micron scale. In order to have a better insight on the molecular arrangement of PVP and Furosemide in composite particles, SERS and surface-enhanced confocal Raman microscopy (SECoRM) are performed on Furosemide, PVP and Furosemide/PVP composites particles sputtered with silver (40 nm). Surface-sensitive SERS and SECoRM maps reveal that Furosemide/PVP particle surfaces mainly consist of PVP molecules coating Furosemide domains. Overall, the combination surface and bulk sensitive analyses allows drawing a clear picture of the particle morphology and the molecular arrangement in Furosemide/PVP sub-micron particles. Namely, SFE-produced Furosemide/PVP sub-micron particles are formed by the agglomeration of primary particles consisting of Furosemide nano-crystals embedded in a thin PVP matrix. Interestingly, both far-field (bulk-sensitive) and surface-enhanced (surface-sensitive) confocal Raman microscopies provide molecular information on a statistically-relevant amount of sub-micron particles in a single microscopic map; this combination is thus an effective and time-saving and tool for investigating organic and inorganic sub-micron composites.</a>

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“…The IR spectrum of (I) (Fig. 5) can be compared with that of furosemide Form I (Bolukbasi & Yilmaz, 2012). The band at 3324 cm À1 (instead of at 3350 cm À1 in Form I) corresponds to the symmetrical (NH 2 ) stretch and the shift indicates that the amino groups are strongly hydrogen bonded in the crystal structure.…”

Section: Ir Spectroscopymentioning

confidence: 99%

A new solvate of furosemide with dimethylacetamide

2016

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The loop diuretic furosemide is used widely in the treatment of congestive heart failure and edema, and is practically insoluble in water. The physicochemical and pharmacokinetic properties of drugs can be modified by preparing the drug in an appropriate solid-state form. A new solvate of furosemide with dimethylacetamide (DMA) {systematic name: 4-chloro-2-[(furan-2-yl)methylamino]-5-sulfamoylbenzoic acid N,N-dimethylacetamide disolvate}, CHClNOS·2CHNO, (I), is reported. The channeled structure formed on slow crystallization contains DMA solvent molecules in its channels. This structure adds to the evidence of varied conformations observed across all known structures, so supporting the idea that this flexible molecule has conformational lability. The current structure also differs from those of other previously known furosemide solvates in the number of solvent molecules per furosemide molecule, viz. 2:1 instead of 1:1. Desolvation of (I) gives the most stable form of furosemide, i.e. Form I.

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X-ray structure analysis and vibrational spectra of Furosemide

Cited by 15 publications

References 16 publications

Multilayer Gold-Silver Bimetallic Nanostructures to Enhance SERS Detection of Drugs

Multilayer Gold-Silver Bimetallic Nanostructures to Enhance SERS Detection of Drugs

Formation Mechanism of Sub-Micron Pharmaceutical Composite Particles derived from Far- and Near Field Raman microscopy

A new solvate of furosemide with dimethylacetamide

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