Xanthine oxidase as a marker of myocardial infarction

Raghuvanshi, Rashmi; Kaul, Aiki; Bhakuni, Pushpa; Mishra, Anupam; Misra, M. K.

doi:10.1007/bf02913321

Cited by 27 publications

(11 citation statements)

References 10 publications

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“…Lipids when react with free radicals, they undergo peroxidation to form lipid peroxides. Lipid peroxides decompose to form numerous products including malondialdehyde [16]. The reaction course is largely influenced by the presence of radical trapping species, particularly oxygen [17].…”

Section: Source and Cellular Response Of Rosmentioning

confidence: 99%

Oxidative stress and human health

Rahman¹,

Hosen²,

Islam³

et al. 2012

ABB

334

214

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Redox degenerative reactions of the biological system inevitably produce reactive oxygen species (ROS) and their derivatives. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species (ROS), such as hydrogen peroxide, organic hydro peroxides, nitric oxide, superoxide and hydroxyl radicals etc. Information are accumulating steadily, supporting the general importance of oxidative damage of tissue and cellular components as a primary or secondary causative factor in many different human diseases and aging processes. Many of the recent landmarks in scientific research have shown that in human beings, oxidative stress has been implicated in the progression of major health problems by inactivating the metabolic enzymes and damaging important cellular components, oxidizing the nucleic acids, leading to cardiovascular diseases, eye disorders, joint disorders, neurological diseases (Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis), atherosclerosis, lung and kidney disorders, liver and pancreatic diseases, cancer, ageing, disease of the reproductive system including the male and female infertility etc. The advent of a growing number of in vitro and in vivo models for evaluating the human disease pathology is aiding scientists in deciphering the detailed mechanisms of the point of intersection of the oxidative stress with other cellular components or events in the growing roadmap leading to different human disorders. The toxic effect of reactive oxygen and nitrogen species in human is balanced by the antioxidant action of non-enzymatic antioxidants, as well as by antioxidant enzymes. Such antioxidant defences are extremely important as they represent the direct removal of free radicals (prooxidants), thus providing maximal protection for biological sites. These systems not only assert with the problem of oxidative damage, but also play a crucial role in wellness, health maintenance, and prevention of chronic and degenerative diseases. In this review we have tried to generate a gross picture on the critical role of ROS in deteriorating human health and the importance of antioxidative defense system in ameliorating the toxicity of ROS

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Section: Source and Cellular Response Of Rosmentioning

confidence: 99%

Oxidative stress and human health

Rahman¹,

Hosen²,

Islam³

et al. 2012

ABB

334

214

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“…When lipids react with ROS, they turn into lipids peroxides. Lipid peroxides generate several products including MDA (Raghuvanshi et al, 2007).…”

Section: Altinoz Et Al Afr J Tradit Complement Alternmentioning

confidence: 99%

The effect of saffron (its active constituent, crocin) on the cardiovascular complication and dyslipidemia in streptozotocin induced diabetic rats

Altınöz¹,

Taskin²,

Oner³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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AbsractBackground: Diabetes mellitus (DM) causes serious complications such as coronary heart disease, atherosclerosis, nephropathy, retinopathy and neuropathy. Materials and Methods: Rats were randomly divided into three groups, each containing 10 rats: control group, DM group; DM+crocin group. Normal saline was administered in the control and DM groups, and crocin was administered in DM+crocin group at a dose of 20 mg/kg bw/day for 21 days. Trunk blood and the hearth tissue were collected for histopathological and biochemical examination. Results: DM led to increment of MDA levels (p<0.05) and the serum levels of total cholesterol, TG, LDL and VLDL (p<0.05) and decrease of GSH levels (p<0.01) compared to control group in serum and heart tissue. Diabetic rats were treated with crocin, MDA levels (p<0.05) and the levels of total cholesterol, TG and VLDL decreased significantly, but GSH levels (p<0.05) increased remarkably compared to DM rats. Statistically significant increase in histopathological damage score was found in the DM group (p<0.0001). Histopathological changes markedly regressed in DM+crocin group. Conclusion: Our results showed that crocin might prevent diabetes induced cardiovascular complications by reduction of oxidative stress and dyslipidemia.

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“…myocardium). 1,2 Acute myocardial infarction (AMI) continues to be a major cause of morbidity and mortality worldwide. 3,4 It remains a leading cause of death in India and represents an enormous cost to health care system.…”

Section: Introductionmentioning

confidence: 99%

Lipid profile and its correlation with C-reactive protein in patients of acute myocardial infarction

et al. 2017

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INTRODUCTIONAcute myocardial infarction (AMI), commonly known as a heart attack, results from the interruption of blood supply to a part of the heart, causing heart cells to die. This is most commonly due to occlusion of a coronary artery following the rupture of a vulnerable atherosclerotic plaque which is an unstable collection of lipids (cholesterol and fatty acids) and white blood cells (especially macrophages) in the wall of an artery. The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period of time, can cause damage or death (infarction) of heart muscle tissue (i.e. myocardium). 1,2Acute myocardial infarction (AMI) continues to be a major cause of morbidity and mortality worldwide.3,4 It remains a leading cause of death in India and represents an enormous cost to health care system. 5 The mortality rate of MI is approximately 30% and for every 1 in 25 patients who survive the initial hospitalization, dies in the first year after AMI. Indians are four time more prone to AMI as compared to the people of other countries due to a combination of the genetic and lifestyle factors that promote metabolic dysfunction. The risk of ABSTRACT Background: Acute myocardial infarction (AMI) is a significant cause of morbidity and mortality worldwide, which results from occlusion of coronary artery. Dyslipidemia is a major risk factor of AMI. C-reactive protein (CRP) is an acute phase protein, synthesized by hepatocytes in response to cytokines released into circulation by activated leukocytes and has been found to increase after AMI. The objective of the present study is to investigate lipid profile in AMI patients and correlate it with inflammatory marker i.e. CRP. Methods: The present study includes 150 AMI patients and 100 normal healthy individuals as controls. In all the cases and controls, serum lipid profile and inflammatory marker were measured by diagnostic kits supplied by ERBA. Results: The levels of lipid profile and inflammatory marker were significantly altered in the AMI cases compared to controls. We found significantly higher levels of total cholesterol, TG, LDL, VLDL, CRP and lower level of HDL in AMI compared to that of control subjects. We also found strong positive correlation of CRP with total cholesterol, triglyceride, LDL-C and VLDL-C and significant negative correlation with HDL-C in AMI patients. Conclusions: We found alterations in the lipid profile and inflammatory marker in AMI cases; hence, all the people should undergo regular check up including lipid profile evaluation and inflammatory marker such as CRP to decrease the incidence, morbidity and mortality from the disease.

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Xanthine oxidase as a marker of myocardial infarction

Abstract: ABSTRACT

Cited by 27 publications

References 10 publications

Oxidative stress and human health

Oxidative stress and human health

The effect of saffron (its active constituent, crocin) on the cardiovascular complication and dyslipidemia in streptozotocin induced diabetic rats

Lipid profile and its correlation with C-reactive protein in patients of acute myocardial infarction

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