Xerogel modified diatomaceous earth microparticles for controlled drug release studies

Uthappa, U.T.; Sriram, G.; Brahmkhatri, Varsha; Kigga, Madhuprasad; Jung, Ho‐Young; Altalhi, Tariq; Neelgund, Gururaj M.; Kurkuri, Mahaveer D.

doi:10.1039/c8nj01238e

Cited by 48 publications

(15 citation statements)

References 33 publications

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“…This drug drawback is short biological half-life and high metabolize rate in the liver, so it should be administered frequently. diatomaceous earth(DE) particles modified with xerogel could prolong and control the release of DS so are suitable carriers for this drug [ 53 ].…”

Section: Microalgal-based Micro-/nanocarriers In Drug Deliverymentioning

confidence: 99%

Microalgae: therapeutic potentials and applications

et al. 2021

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Recently, special attention has been paid to marine origin compounds such as carbohydrates, peptides, lipids, and carotenoids, which are extracted from microalgae and have anticancer, anti-inflammatory, antimicrobial (e.g., anti-COVID-19 activity), and antioxidant properties in biomedicine and pharmaceutical biotechnology. In addition, these photosynthetic marine microorganisms have several applications in biotechnology and are suitable hosts for the production of recombinant proteins/peptides, such as monoclonal antibodies and vaccines. Silica-based nanoparticles obtained from diatoms (a microalgae group) are used as drug delivery carriers owing to their biodegradability, easy functionalization, low cost, and simple features compared to synthetics, which make these agents proper alternatives for synthetic silica nanoparticles. Therefore, diatom-based nanoparticles are a viable option for the delivery of anti-cancer drugs and reducing the side-effects of cancer chemotherapy.

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Section: Microalgal-based Micro-/nanocarriers In Drug Deliverymentioning

confidence: 99%

Microalgae: therapeutic potentials and applications

et al. 2021

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“…In 2018, Uthappa et al investigated the use of a novel hybrid material made of diatoms modified with silica xerogel, covalently linked to the surface of DE microparticles (Figure 15) [84]. Dicoflenac, a nonsteroidal anti-inflammatory drug (NSAID) used to treat inflammatory diseases, was chosen as a drug model in a study showing that drug loading and sustained release properties are considerably improved in the xerogel-DE material when compared with neat DE.…”

Section: Diatom Composite Formulations In Drug Delivery Systemsmentioning

confidence: 99%

“…Inset: chemical structure of diclofenac sodium drug. Reproduced from [84] with permission from the Centre National de la Recherche Scientifique (CNRS) and The Royal Society of Chemistry.…”

Section: Figurementioning

confidence: 99%

Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems

Delasoie

Zobi

2019

Pharmaceutics

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Unicellular diatom microalgae are a promising natural resource of porous biosilica. These microorganisms produce around their membrane a highly porous and extremely structured silica shell called frustule. Once harvested from living algae or from fossil sediments of diatomaceous earth, this biocompatible and non-toxic material offers an exceptional potential in the field of micro/nano-devices, drug delivery, theranostics, and other medical applications. The present review focused on the use of diatoms in the field of drug delivery systems, with the aim of presenting the different strategies implemented to improve the biophysical properties of this biosilica in terms of drug loading and release efficiency, targeted delivery, or site-specific binding capacity by surface functionalization. The development of composite materials involving diatoms for drug delivery applications is also described.

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“…Although aerogels are higher in porosity and specific surface area, the synthesis of the xerogels under ambient pressure drying, which does not require energy-consuming instruments, has made the xerogels desirable materials, especially in the cases of operational risks and economic issues [ 18 ]. The intermediate porosity of xerogels is highly preferable in sustained drug release; the high porosity of aerogels may lead to fast drug release, which is not desirable in some cases, such as cancer drug therapy [ 19 , 20 ]. Several research papers have been recently published regarding the fabrication and characterization of biopolymeric xerogels for different medical and biomedical applications [ 21 , 22 , 23 ], which are increasing by the day.…”

Section: Introductionmentioning

confidence: 99%

Insights into the Role of Biopolymer-Based Xerogels in Biomedical Applications

Khalil

Yahya

Tajarudin

et al. 2022

Gels

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Xerogels are advanced, functional, porous materials consisting of ambient, dried, cross-linked polymeric networks. They possess characteristics such as high porosity, great surface area, and an affordable preparation route; they can be prepared from several organic and inorganic precursors for numerous applications. Owing to their desired properties, these materials were found to be suitable for several medical and biomedical applications; the high drug-loading capacity of xerogels and their ability to maintain sustained drug release make them highly desirable for drug delivery applications. As biopolymers and chemical-free materials, they have been also utilized in tissue engineering and regenerative medicine due to their high biocompatibility, non-immunogenicity, and non-cytotoxicity. Biopolymers have the ability to interact, cross-link, and/or trap several active agents, such as antibiotic or natural antimicrobial substances, which is useful in wound dressing and healing applications, and they can also be used to trap antibodies, enzymes, and cells for biosensing and monitoring applications. This review presents, for the first time, an introduction to biopolymeric xerogels, their fabrication approach, and their properties. We present the biological properties that make these materials suitable for many biomedical applications and discuss the most recent works regarding their applications, including drug delivery, wound healing and dressing, tissue scaffolding, and biosensing.

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Xerogel modified diatomaceous earth microparticles for controlled drug release studies

Abstract: An alternative facile approach for the surface modification of naturally available diatoms with xerogel for controlled drug release applications.

Cited by 48 publications

References 33 publications

Microalgae: therapeutic potentials and applications

Microalgae: therapeutic potentials and applications

Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems

Insights into the Role of Biopolymer-Based Xerogels in Biomedical Applications

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