Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NF-κB signaling pathway

Zhu, Yanru; Luo, Lifei; Zhang, Meng; Song, Xiu-Neng; Wang, Ping; Zhang, Han; Zhang, Jingze; Liu, Dailin

doi:10.1016/j.jep.2022.115833

Cited by 17 publications

(6 citation statements)

References 34 publications

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“…A mouse model of pulmonary fibrosis bleomycin treated with Xuanfei Baidu decoction showed that this medicine could effectively protect the alveolar structure, reduce the cellular changes of lung, improve the infiltration of inflammatory cells, and inhibit the thickening of the blood vessel wall and collagen deposition; furthermore, after network pharmacology and protein-protein interaction analysis, we found that the above effects were related to inhibition of the activation of interleukin (IL)-6/STAT3 signaling pathway, preventing the differentiation of M2 macrophages, and downregulating the overexpression of inflammatory factors such as IL-6 and transforming growth factor (TGF)-β [14] . The model of acute lung injury induced by lipopolysaccharide LPS showed that Xuanfei Baidu decoction can improve the pathological changes of lung tissue in mice, downregulate the levels of inflammatory factors IL-6, tumor necrosis factor (TNF)-α, and IL-1β in serum and alveolar lavage fluid of mice, and also inhibit the infiltration of macrophages and neutrophils [15][16][17] . Its mechanism is related to the inhibition of programmed death (PD)-1/IL17A pathways [15] and the polarization of proinflammatory macrophages by increasing mitochondrial fusion and inhibiting the activation of NLRP3 inflammatory bodies mediated by nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways [16][17] .…”

Section: Discussionmentioning

confidence: 99%

“…The model of acute lung injury induced by lipopolysaccharide LPS showed that Xuanfei Baidu decoction can improve the pathological changes of lung tissue in mice, downregulate the levels of inflammatory factors IL-6, tumor necrosis factor (TNF)-α, and IL-1β in serum and alveolar lavage fluid of mice, and also inhibit the infiltration of macrophages and neutrophils [15][16][17] . Its mechanism is related to the inhibition of programmed death (PD)-1/IL17A pathways [15] and the polarization of proinflammatory macrophages by increasing mitochondrial fusion and inhibiting the activation of NLRP3 inflammatory bodies mediated by nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways [16][17] . In addition, Xuanfei Baidu decoction can also improve weight loss, spleen index, disease activity index, TNF-α level, and colon tissue injury of mice with acute colitis.…”

Section: Discussionmentioning

confidence: 99%

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Expert Consensus on the clinical application of Xuanfei Baidu granule

Liu¹,

Zhang²,

Wang³

et al. 2023

Acupuncture and Herbal Medicine

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Xuanfei Baidu granule is an effective prescription for COVID-19, which is modified from classical famous prescriptions. In order to further standardize clinician’s rational use of Xuanfei Baidu granule, enhance clinical efficacy, improve rational medication level, and let it play a more significant role, the frontline clinical experts are invited for discussion on the major functions, usage, adverse reactions, and considerations of Xuanfei Baidu granule to form the consensus. The consensus is that: Xuanfei Baidu granule has the efficacy of promoting the lung and resolving dampness, clearing heat and removing pathogeneses, purging the lung and depoisoning; it can be used for the treatment of patients with mild, moderate, and heavy COVID-19 and other common upper respiratory tract infectious diseases such as influenza; acute tracheitis and bronchitis and community-acquired lower respiratory tract infectious diseases all belong to damp-toxin constraint in the lungs, Xuanfei Baidu granule can relieve cough, expectoration, and other symptoms caused by an acute exacerbation of the chronic obstructive pulmonary disease, with definite clinical efficacy and good safety. According to the principles of evidence-based medicine, this expert consensus will be updated regularly.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Expert Consensus on the clinical application of Xuanfei Baidu granule

Liu¹,

Zhang²,

Wang³

et al. 2023

Acupuncture and Herbal Medicine

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“…Administration of 20 mg/ml P. oleracea in mice with atopic dermatitis led to decrease of serum level of Ig E and histamine HIS, reduction of infammatory mediators such as TNF-α, IFN-c and IL-4 as well as mast cell infltration [175].…”

Section: Immunomodulatory Effectsmentioning

confidence: 92%

Phytochemical Characteristics and Anti‐Inflammatory, Immunoregulatory, and Antioxidant Effects of Portulaca oleracea L.: A Comprehensive Review

Ghorani,

Saadat,

Khazdair

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Portulaca oleracea L. (P. oleracea) or purslane is a plant from the Portulacaceae family, which is used as food and traditional medicine for various diseases. This review article provides comprehensive information on the antioxidant, immunomodulatory, and anti-inflammatory properties of P. oleracea and its constituents. The literature survey of the different databases until the end of June 2023 was explored based on the keywords including the “P. oleracea, purslane, anti-inflammatory, immunomodulatory, and antioxidant properties.” The plant contains flavonoids, alkaloids, terpenoids, fatty acids, vitamins, minerals, and some other compounds. The results indicated that P. oleracea and its constituents showed anti-inflammatory and immunomodulatory properties through reduction of inflammatory mediators including interferon gama (IFN-γ), interleukin (IL)-10, IL-4, tumor necrosis factor-alpha (TNF-α), and nitric oxide. Improvement in cytokines’ serum levels (IFN-γ, IL-10, and IL-4) and increased IgG and IgM serum levels, as well as reduction of IgE, phospholipase A2, and total protein were demonstrated for P. oleracea. The plant and its constituents also improved oxidative stress by reduction of oxidant and increase of antioxidant markers. P. oleracea could be considered as an effective remedy for various inflammatory and immune diseases.

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“…Yin et al, 2021; Zhao, Liu, et al (2023) identified 104 compounds in XFBD and found that 67 of these constituents, including 21 in the prototype, were absorbed into mouse sera (Zhao, Liu, et al, 2023). Zhu et al (2023) identified 113 compounds in XFBD prescription (Zhu et al, 2023), whereas Wang, Quan, et al (2022) identified only 42 constituents in XFBD granule, 25 of which were absorbed in vivo (Wang, Quan, et al, 2022). They also compared the pharmacokinetics of 24 constituents of XFBD granules in normal rats and rats with acute respiratory distress syndrome (Wang, Zhang, et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Identification of Xuanfei Baidu granule constituents by liquid chromatography–quadruple‐time‐of‐flight–mass spectrometry and its anti‐inflammatory active constituents using a lipopolysaccharide‐induced RAW264.7 cell model

Li,

Zhao,

Liang

et al. 2024

Biomedical Chromatography

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The Xuanfei Baidu (XFBD) prescription, a traditional Chinese medicine prescription, has demonstrated significant anti‐inflammatory activities; however, the number of its reported constituents is limited, and its anti‐inflammatory constituents are unclear. In this study, the constituents of XFBD granule, a granule dosage of XFBD prescription, were thoroughly examined in vitro and in vivo using liquid chromatography–quadruple‐time‐of‐flight–mass spectrometry, and the anti‐inflammatory constituents were screened. A total of 214 constituents were identified from the XFBD granule, 62 of which were confirmed via comparison with reference standards. After intragastric administration of XFBD granule, 63 and 28 constituents were absorbed into the rat sera and lungs in prototype form, respectively. XFBD granule and XFBD‐containing serum were found to significantly reduce nitric oxide (NO) and interleukin‐6 (IL‐6) secretion in lipopolysaccharide‐induced RAW264.7 cells. Five anti‐inflammatory constituents (verbasoside, scutellarin, luteolin, apigenin, and pogostone) were found to reduce the concentration of NO and IL‐6 in a dose‐dependent manner. Moreover, the combination of these five constituents could significantly reduce NO secretion even when the concentration of each constituent was two to three orders of magnitude lower than their individual minimum effective concentrations. Overall, this study provides a valuable reference for the discovery of effective constituents from the XFBD granule.

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Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NF-κB signaling pathway

Cited by 17 publications

References 34 publications

Expert Consensus on the clinical application of Xuanfei Baidu granule

Expert Consensus on the clinical application of Xuanfei Baidu granule

Phytochemical Characteristics and Anti‐Inflammatory, Immunoregulatory, and Antioxidant Effects of Portulaca oleracea L.: A Comprehensive Review

Identification of Xuanfei Baidu granule constituents by liquid chromatography–quadruple‐time‐of‐flight–mass spectrometry and its anti‐inflammatory active constituents using a lipopolysaccharide‐induced RAW264.7 cell model

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