Y2O3 Nanoparticles Caused Bone Tissue Damage by Breaking the Intracellular Phosphate Balance in Bone Marrow Stromal Cells

Gao, Chunyue; Jin, Y.; Jia, Guang; Suo, Xiaomin; Liu, Huifang; Liu, Dandan; Yang, Xinjian; Ge, Kun; Liang, Xing‐Jie; Wang, Shuxiang; Zhang, Jinchao

doi:10.1021/acsnano.8b06211

Cited by 108 publications

(25 citation statements)

References 48 publications

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“…Nevertheless, for spherical Y 2 O 3 NPs, cell viability was found invariant for various high concentrations, up to 500 µg/mL, with no statistical difference as compared with control samples [ 12 ]. A recent in vivo toxicity study of Y 2 O 3 NPs shows that after intravenous injection in mice, the yttrium mostly accumulates in bones and causes cell apoptosis by breaking the intracellular phosphate balance in stromal cells [ 14 ]. On the other side, it has been reported that Y 2 O 3 NPs have protective and antioxidant effect in murine hippocampal HT22 cells [ 15 ] and isolated rat pancreatic islets [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells

et al. 2021

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The innovative strategy of using nanoparticles in radiotherapy has become an exciting topic due to the possibility of simultaneously improving local efficiency of radiation in tumors and real-time monitoring of the delivered doses. Yttrium oxide (Y2O3) nanoparticles (NPs) are used in material science to prepare phosphors for various applications including X-ray induced photodynamic therapy and in situ nano-dosimetry, but few available reports only addressed the effect induced in cells by combined exposure to different doses of superficial X-ray radiation and nanoparticles. Herein, we analyzed changes induced in melanoma cells by exposure to different doses of X-ray radiation and various concentrations of Y2O3 NPs. By evaluation of cell mitochondrial activity and production of intracellular reactive oxygen species (ROS), we estimated that 2, 4, and 6 Gy X-ray radiation doses are visibly altering the cells by inducing ROS production with increasing the dose while at 6 Gy the mitochondrial activity is also affected. Separately, high-concentrated solutions of 25, 50, and 100 µg/mL Y2O3 NPs were also found to affect the cells by inducing ROS production with the increase of concentration. Additionally, the colony-forming units assay evidenced a rather synergic effect of NPs and radiation. By adding the NPs to cells before irradiation, a decrease of the number of proliferating cell colonies was observed with increase of X-ray dose. DNA damage was evidenced by quantifying the γ-H2AX foci for cells treated with Y2O3 NPs and exposed to superficial X-ray radiation. Proteomic profile confirmed that a combined effect of 50 µg/mL Y2O3 NPs and 6 Gy X-ray dose induced mitochondria alterations and DNA changes in melanoma cells.

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Section: Introductionmentioning

confidence: 99%

Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells

et al. 2021

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“…Y 2 O 3 nanoparticles are gaining interest for application in photodynamic therapy and biological imaging of cancerous cells 7–9. Also, Gao et al (2019)10 have reported that bone marrow tissue was damaged by Y 2 O 3 nanoparticles’ exposure. Liu et al11 have reported that rare earth nanoparticles can be transported in the human body and deposited in mice bone.…”

Section: Introductionmentioning

confidence: 99%

Apoptotic and DNA-damaging effects of yttria-stabilized zirconia nanoparticles on human skin epithelial cells

Alzahrani¹,

Katubi²,

Ali³

et al. 2019

IJN

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BackgroundYttria-stabilized zirconia (Y2O3/ZrO2) nanoparticles are one of the important nanoparticles extensively used in manufacturing of plastics, textiles, catalyst, etc. Still, the cytotoxic and apoptotic effects of yttria-stabilized zirconia nanoparticles have not been well identified on human skin keratinocyte (HaCaT) cells. Therefore, in this study, we have designed to examine the cytotoxic potential of yttria-stabilized zirconia nanoparticles in HaCaT cells.MethodsPrior to treatment, the yttria-stabilized zirconia nanoparticles were characterized by using different advanced instruments viz. dynamic light scattering (DLS), scanning electron microscope (SEM) and transmission electron microscope (TEM). Cell viability of HaCaT cells was measured by using MTS and NRU assays and viability of cells was reduced in a dose- and time-dependent manner.ResultsReduction in the viability of cells was correlated with the rise of reactive oxygen species generation, increased caspase-3, mitochondria membrane potential and evidence of DNA strand breakage. These were consistent with the possibility that mitochondria damage can play a significant role in the cytotoxic response. Moreover, the activity of oxidative enzymes such as lipid peroxide (LPO) was increased and glutathione was reduced in HaCaT cells exposed with yttria-stabilized zirconia nanoparticles. It is also important to indicate that HaCaT cells appear to be more susceptible to yttria-stabilized zirconia nanoparticles exposure after 24 hrs.ConclusionThis result provides a dose- and time-dependent apoptosis and genotoxicity of yttria-stabilized zirconia nanoparticles in HaCaT cells.

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“…The strength of neuronal connections, that is, synaptic weight, between neurons is defined as synaptic plasticity, which is a key factor affecting human brain learning, memory and other basic neural activities. [17] A series of neuromorphic devices have been fabricated to realize artificial synapse, including twoterminal memristors [phase change memory, [18][19][20][21] resistive random-access memory, [22][23][24][25][26][27][28] etc.] and three-terminal transistors [29][30][31][32][33] over the past decades.…”

Section: Doi: 101002/smll202103837mentioning

confidence: 99%

Near‐Infrared Artificial Synapses for Artificial Sensory Neuron System

Guo

Liao

et al. 2021

Small

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The computing based on artificial neuron network is expected to break through the von Neumann bottleneck of traditional computer, and to greatly improve the computing efficiency, displaying a broad prospect in the application of artificial visual system. In the specific structural layout, it is a common method to connect the discrete photodetector with the artificial neuron in series, which enhances the complexity of signal recognition, conversion and storage. In this work, organic small molecule IR‐780 iodide is inserted into the memory device as both the charge trapping layer and near‐infrared (NIR) photoresponsive film. Through electrical and optical regulation, artificial synaptic functions including short‐term plasticity, long‐term plasticity, and spike rate dependence are realized. In the established artificial sensory neuron system, NIR optical pulses can significantly improve the spiking rate. Moreover, the spiking neural networks are further constructed by simulation for handwritten digit classification. This research may contribute to the development of light driven neural robots, optical signal encryption, and neural computing.

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Y₂O₃ Nanoparticles Caused Bone Tissue Damage by Breaking the Intracellular Phosphate Balance in Bone Marrow Stromal Cells

Cited by 108 publications

References 48 publications

Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells

Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells

<p>Apoptotic and DNA-damaging effects of yttria-stabilized zirconia nanoparticles on human skin epithelial cells</p>

Near‐Infrared Artificial Synapses for Artificial Sensory Neuron System

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