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Abstract

ABSTRACT:The in vitro antimicrobial activity of acetone, methanol and water extracts of leaf, stem bark and fruit of Elaeocarpus serratus L. (Elaeocarpaceae) was examined against four bacterial species (Shigella sonnei, Salmonella typhi, Staphylococcus aureus and Klebsiella pneumoniae) and a fungal species (Candida albicans) using the agar well diffusion method. Phytochemical screening was carried out for phenols, flavonoids and tannins. Results showed that the plant extracts exhibited a dose-dependent inhibition of microorganisms. The acetone and methanol extracts of leaf and stem bark of E. serratus displayed maximum antibacterial activity against all the bacterial species studied. The plant extracts also displayed high antifungal activity against Candida albicans especially, the acetone extract was found to be more active antifungal. Generally, the lower concentrations of the extracts were susceptible to the fungal pathogen. E. serratus extracts contained phenols, flavonoids and tannins at varying levels. The ability of the crude extracts of the test plant to inhibit the growth of bacteria and fungi is an indication of its broad spectrum antimicrobial potential which may be employed in the management of microbial infections.

BIOLOGICAL ACTIVITY OF METHANOL EXTRACT OF Elaeocarpus mastersii KING: ANTIOXIDANT, ANTIBACTERIAL, AND α-GLUCOSIDASE INHIBITOR

“…Plants of the Elaeocarpus genus have a great impact to treat various diseases such as epilepsy, hypertension, asthma, and arthritis 2 . Several studies showed the great biological activity of Elaeocarpus plants from crude extracts and pure compounds as the antioxidant [3][4][5][6] , antimicrobial [7][8][9] , antidiabetic 10 , antiinflammatory 2,11 , cytotoxic 4,5,12,13 , medicine of bronchial asthma 14 , antiarthritic 15 , antidepressant 16 , and antiparkinsonian 17 . Elaeocarpus mastersii King belongs to the Elaeocarpus genus used as the natural medicine of diabetic and hypertensive disease.…”