Yacon (Smallanthus sonchifolius)-based product increases fecal short-chain fatty acids and enhances regulatory T cells by downregulating RORγt in the colon of BALB/c mice

Yacón (Smallanthus sonchifolius) prevented inflammation, oxidative stress, and intestinal alterations in an animal model of colorectal carcinogenesis

“…In addition, the intake of prebiotics is beneficial to the physiological status of the intestines by decreasing the intraluminal pH, which is associated with better luminal moisture content 54 . In agreement with previous studies, 18–43 the present study showed that YF supplementation reduced the intraluminal pH, which may be due to FOS fermentation. The reduction in intraluminal pH inhibits the proliferation of pathogenic bacteria and the activity of microbial enzymes involved in the production of carcinogenic by‐products 55 .…”

“…35 Thus, an auto-regulatory loop seemingly exists in which TNF-⊍ stimulates IL-10 production, which, in turn, reduces TNF-⊍ synthesis. 40 BALB/c mice supplemented with a yacón-based product (60 g kg −1 FOS) showed an increase in the percentage of regulatory T cells (T reg) in the colon, 41 and these cells also produce IL-10. 40 YF is a source of phenolic acids, mainly caffeic and chlorogenic acids, which help to reduce oxidative stress, and studies have shown that it has high antioxidant capacity.…”

“…Thus, an auto‐regulatory loop seemingly exists in which TNF‐α stimulates IL‐10 production, which, in turn, reduces TNF‐α synthesis 40 . BALB/c mice supplemented with a yacón‐based product (60 g kg −1 FOS) showed an increase in the percentage of regulatory T cells (T reg) in the colon, 41 and these cells also produce IL‐10 40…”

Evaluation of the efficacy of probiotic VSL#3 and synbiotic VSL#3 and yacon‐based product in reducing oxidative stress and intestinal permeability in mice induced to colorectal carcinogenesis

“…et al, 2012). This dose was defined based on previous studies in human and animal models, where several beneficial effects were observed, such as modulation of the immune system, reduction of constipation, increased integrity of crypts, and production of SCFA, without causing diarrhea (De Nadai Marcon et al, 2020;De Nadai Marcon et al, 2019;Sant'Anna et al, 2018).…”

“…The yacon-based product (PBY) is a concentrate produced with yacon in natura and which has higher concentrations of prebiotics FOS and inulin when compared to fresh root (Rodrigues et al, 2011). Recently, the ability of PBY to reduce oxidative stress, reduce damage to intestinal crypts, and increase the production of short-chain fatty acids (SCFAs), particularly butyrate, in a colorectal carcinogenesis model was demonstrated (De Nadai Marcon et al, 2020;De Nadai Marcon et al, 2019).…”