Yolk sac tumor of the ovary

T, Van Thielen; Degryse, H; Coeman, D

doi:10.5334/jbr-btr.313

Cited by 4 publications

(17 citation statements)

References 3 publications

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“…Los TSEO son un tipo de neoplasia maligna derivada de las células pluripotenciales del ovario, que se diferencian en estructuras del saco vitelino [1][2][3] . Representan la segunda neoplasia de células germinales maligna más común (20-22%) 1,3-4 , siendo la primera el disgerminoma (48%) 3-4 y la tercera el teratoma ovárico inmaduro 2 .…”

Section: Discussionunclassified

“…Se ha descrito, además, en la literatura científica una cierta asociación de los tumores de células germinales con mujeres con gónadas disgenéticas y un importante componente cromosómico Y 8 . La franja de edad con mayor prevalencia se encuentra entre los 18-30 años [3][4] , siendo por encima de los 40 años muy infrecuente 1,9 , presentándose en estos casos, asociados a otros tumores ováricos, en especial al adenocarcinoma endometrial 9 . La etiología de los tumores germinales es actualmente desconocida 4 .…”

Section: Discussionunclassified

“…Los tumores del seno endodérmico ovárico (TSEO) son un tipo de neoplasia maligna derivada de las células multipotenciales primitivas del ovario, que se diferencian en estructuras del saco vitelino [1][2][3] . Son tumoraciones muy infrecuentes 1,[3][4] , caracterizadas por un crecimiento muy rápido 4 y que suele presentarse en adolescentes y mujeres jóvenes en edad reproductiva [2][3][4][5][6] , con una prevalencia estimada del 1-3% de las neoplasias ováricas malignas 1,4,7 .…”

Section: Introductionunclassified

“…Son tumoraciones muy infrecuentes 1,[3][4] , caracterizadas por un crecimiento muy rápido 4 y que suele presentarse en adolescentes y mujeres jóvenes en edad reproductiva [2][3][4][5][6] , con una prevalencia estimada del 1-3% de las neoplasias ováricas malignas 1,4,7 . El diagnóstico de sospecha se basa en la combinación de la historia clínica, exploración física, pruebas de imagen y marcadores tumorales [2][3] ; aunque la confirmación definitiva se obtiene normalmente, tras la valoración histológica de las muestras quirúrgicas [3][4] .…”

Section: Introductionunclassified

“…El diagnóstico de sospecha se basa en la combinación de la historia clínica, exploración física, pruebas de imagen y marcadores tumorales [2][3] ; aunque la confirmación definitiva se obtiene normalmente, tras la valoración histológica de las muestras quirúrgicas [3][4] . La terapia de elección en la actualidad es la cirugía combinada con quimioterapia adyuvante 1,5 , obteniendo en muchas ocasiones, remisiones completas de la enfermedad 2 .…”

Section: Introductionunclassified

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Tumor ovárico del seno endodérmico (Yolk Sac). Dolor abdominal en el puerperio inmediato como síntoma diagnóstico.

Ruíz

Garrido

Sánchez

et al. 2018

Rev. chil. obstet. ginecol.

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Tumor ovárico del seno endodérmico (Yolk Sac). Dolor abdominal en el puerperio inmediato como síntoma diagnóstico. RESUMENLos tumores del seno endodérmico ovárico (Yolk Sac), son neoplasias malignas de origen germinal, que se caracterizan por su diferenciación embriológica a partir de estructuras del saco vitelino. Son tumoraciones muy infrecuentes, de crecimiento rápido y que suelen desarrollarse en adolescentes y mujeres jóvenes, en edad reproductiva. Su diagnóstico se basa en la combinación de pruebas de imagen asociado a niveles plasmáticos elevados de marcadores tumorales como la alfafetoproteína. El manejo terapéutico es eminentemente quirúrgico (pudiendo ser conservador en pacientes con deseo genésico no cumplido), asociado a pautas de quimioterapia sistémica combinada con bleomicina, etopósido y platino. Exponemos el caso de una paciente que en el puerperio tardío, presenta un cuadro clínico de dolor, distensión abdominal y fiebre, siendo diagnosticada tras el tratamiento quirúrgico y el estudio histológico posterior, de un tumor del seno endodérmico ovárico. PALABRAS CLAVE:Tumor seno endodérmico, tumor Yolk Sac, gestación, neoplasia de células germinales y embrional, dolor abdominal, puerperio. ABSTRACTOvarian endodermal sinus tumors (Yolk Sac), are malignant neoplasms of germinal origin, which are characterized by their embryological differentiation from yolk sac structures. These tumors are very infrequent, of rapid growth and tend to develop in adolescents and young women of reproductive age. Its diagnosis is based on the combination of imaging tests associated with high plasma levels of tumor markers such as alphafetoprotein. The therapeutic management is eminently surgical (with a more conservative approach reserved for patients still considering later pregnancy), associated with patterns of systemic chemotherapy combined with bleomycin, etoposide and platinum. We present the case of a patient who, in the late puerperium, presents symptoms of pain, abdominal distension and fever, being diagnosed after the surgical treatment and the subsequent histological study of a tumor of the endodermal ovarian sinus.

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Section: Discussionunclassified

Section: Introductionunclassified

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Tumor ovárico del seno endodérmico (Yolk Sac). Dolor abdominal en el puerperio inmediato como síntoma diagnóstico.

Ruíz

Garrido

Sánchez

et al. 2018

Rev. chil. obstet. ginecol.

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Clinical analysis of 52 adolescent patients with ovarian masses ≥10 cm in diameter

Zhang

Meng

2021

J Int Med Res

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Objective To investigate the clinical characteristics and treatment of large ovarian masses in adolescents. Methods Adolescents with large ovarian masses (≥10 cm in diameter) who were treated in Beijing Obstetrics and Gynecology Hospital from March 2010 to December 2018 were retrospectively assessed. Results Fifty-two female patients (mean age: 16.17±2.04 years [11–19 years]) were included and 19 (36.5%) presented with abdominal pain. The blood flow signal rate in ultrasonography was significantly different among benign, borderline and malignant ovarian masses, unlike strong echo, dotted echo and septation rates. Carbohydrate antigen 125 positivity rates were significantly different among pathological types and the endometriotic cyst group showed the highest value (75.0%). Alpha-fetoprotein positivity rates were also different among pathological types. For ovarian cystectomy, 14 and 32 patients underwent laparotomy and laparoscopy, respectively. Mass diameters were significantly higher in the laparotomy group and the operative duration was significantly shorter in the laparoscopy group. There were no significant differences in intraoperative blood loss or postoperative recurrence rates between the two groups. Conclusion Teratomas constitute the greatest group of large ovarian masses in adolescents. Benign tumors should be treated by laparoscopic resection, while borderline or malignant tumors require individualized treatment of tumors and fertility-sparing treatments.

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Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases

Guo

Ren

et al. 2016

Molecular and Clinical Oncology

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Solid pseudopapillary tumors (SPTs) are unusual neoplasms that mostly occur in the pancreas, and predominantly affect young women. As a low-grade malignant neoplasm of the exocrine pancreas, they occasionally metastasize, usually to the liver or peritoneum. It has been reported that <1% of SPTs are primary extrapancreatic SPTs. In the present study, we present two rare, but conspicuous extrapancreatic SPTs. Both occurred in young women, and showed good prognoses following surgery. One was a recurrent SPT of the pancreas that metastasized to the ovary, and the other was a distinct primary neoplasm that arose in the retroperitoneal area. The pathological features of the two tumors, including solid and pseudopapillary growth patterns with pale or eosinophilic cytoplasm, were characteristic of SPTs of the pancreas. However, in the case of the metastatic ovarian tumor, focal necrosis and an increased nuclear-to-cytoplasmic ratio were observed. The presence of positive nuclear-cytoplasmic β-catenin, the loss of membranous E-cadherin expression, and a perinuclear punctate CD99 staining pattern on immunohistochemistical analysis, were essential features for diagnosis. The aim of the present study was to compare the morphological and immunohistochemical features of these tumors with those typical of pancreatic SPTs, and to raise awareness that SPTs are able to metastasize to unusual sites, and may also arise as primary tumors outside the pancreas, which may lead to diagnostic dilemmas. Case reports Clinical features Case 1. A 22-year-old woman presented at the Emergency Department of our hospital with sudden abdominal pain; two years previously, the patient had been diagnosed with a pancreatic SPT that had extensively metastasized into the abdominal cavity. A review of her medical history revealed that the patient

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Yolk sac tumor of the ovary

Cited by 4 publications

References 3 publications

Tumor ovárico del seno endodérmico (Yolk Sac). Dolor abdominal en el puerperio inmediato como síntoma diagnóstico.

Tumor ovárico del seno endodérmico (Yolk Sac). Dolor abdominal en el puerperio inmediato como síntoma diagnóstico.

Clinical analysis of 52 adolescent patients with ovarian masses ≥10 cm in diameter

Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases

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