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doi:10.1111/bph.1996.117.issue-4

British J Pharmacology

1996

DOI: 10.1111/bph.1996.117.issue-4

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New water soluble glycosides of 11-keto-β-boswellic acid: A paradigm

Manjunath

Shenvi

Raja

et al. 2017

Natural Product Research

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Though several glycosides of various triterpenes are known, but surprisingly no boswellic acid glycosides are reported so far. With a view to make water soluble boswellic acids, prepared glycosides of 11-keto boswellic acid for the first time. Naturally occurring boswellic acids which are anti-inflammatory agents are lipophylic in nature and thus, become a limiting factor in terms of their bioavailability. Among boswellic acids, 11-keto-β-boswellic acid is found to exhibit superior biological activity and hence successfully prepared its glucosyl and maltosyl derivatives viz., 11-keto-β-boswellic acid-24-O-β-D-glucopyranoside (9) and 11-keto-β-boswellic acid-24-O-α-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (15) which are water soluble. Both these compounds are soluble in water to the extent of 10% (w/w) which is very significant.

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New water soluble glycosides of 11-keto-β-boswellic acid: A paradigm

Manjunath

Shenvi

Raja

et al. 2017

Natural Product Research

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Cited by 1 publication

References 47 publications

New water soluble glycosides of 11-keto-β-boswellic acid: A paradigm

New water soluble glycosides of 11-keto-β-boswellic acid: A paradigm

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