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Though several glycosides of various triterpenes are known, but surprisingly no boswellic acid glycosides are reported so far. With a view to make water soluble boswellic acids, prepared glycosides of 11-keto boswellic acid for the first time. Naturally occurring boswellic acids which are anti-inflammatory agents are lipophylic in nature and thus, become a limiting factor in terms of their bioavailability. Among boswellic acids, 11-keto-β-boswellic acid is found to exhibit superior biological activity and hence successfully prepared its glucosyl and maltosyl derivatives viz., 11-keto-β-boswellic acid-24-O-β-D-glucopyranoside (9) and 11-keto-β-boswellic acid-24-O-α-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (15) which are water soluble. Both these compounds are soluble in water to the extent of 10% (w/w) which is very significant.

Organic chemistry Z 0200Various Approaches for the Synthesis of 1,2-Dideoxy-β-aryl or Heteroaryl-D-ribo-furanose Frameworks -[81 refs.]. -(MAHALINGAM, S. M.; MANJUNATH, B. N.; AIDHEN, I. S.; Proc. Indian Natl. Sci. Academy, Part A: Phys. Sci. 71 (2005) 3-4, 267-282; Dep. Chem., Indian Inst. Technol., Chennai 600 036, India; Eng.) -Lindner 23-247

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