Zanthoxylum alkylamides ameliorate protein metabolism disorder in STZ-induced diabetic rats

Ren, Tingyuan; Zhu, Yanhua; Xia, Xuejuan; Ding, Yongbo; Guo, Jing; Kan, Jianquan

doi:10.1530/jme-16-0218

Cited by 34 publications

(25 citation statements)

References 51 publications

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“…As a global disease, DM not only is characterized by elevated blood glucose and blood lipid levels but also displays a protein metabolic disorder, which is primarily caused by the absolute or relative deficiency in insulin secretion [98]. Insulin can promote protein synthesis and inhibit protein decomposition [99], and increased insulin and insulin-like growth factor 1 (IGF1) levels in the serum can improve the protein metabolism (Figure 1). Compared with that in a normal group, protein catabolism in diabetic models was significantly ameliorated, while protein synthesis and the mRNA expression of the IR, IGF1, and IGF1 receptor (IGF1R) were markedly decreased [100].…”

Section: Protein Changes In Ad and Dmmentioning

confidence: 99%

Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease

Sun

et al. 2020

Journal of Diabetes Research

119

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As a chronic metabolic disease, diabetes mellitus (DM) is broadly characterized by elevated levels of blood glucose. Novel epidemiological studies demonstrate that some diabetic patients have an increased risk of developing dementia compared with healthy individuals. Alzheimer’s disease (AD) is the most frequent cause of dementia and leads to major progressive deficits in memory and cognitive function. Multiple studies have identified an increased risk for AD in some diabetic populations, but it is still unclear which diabetic patients will develop dementia and which biological characteristics can predict cognitive decline. Although few mechanistic metabolic studies have shown clear pathophysiological links between DM and AD, there are several plausible ways this may occur. Since AD has many characteristics in common with impaired insulin signaling pathways, AD can be regarded as a metabolic disease. We conclude from the published literature that the body’s diabetic status under certain circumstances such as metabolic abnormalities can increase the incidence of AD by affecting glucose transport to the brain and reducing glucose metabolism. Furthermore, due to its plentiful lipid content and high energy requirement, the brain’s metabolism places great demands on mitochondria. Thus, the brain may be more susceptible to oxidative damage than the rest of the body. Emerging evidence suggests that both oxidative stress and mitochondrial dysfunction are related to amyloid-β (Aβ) pathology. Protein changes in the unfolded protein response or endoplasmic reticulum stress can regulate Aβ production and are closely associated with tau protein pathology. Altogether, metabolic disorders including glucose/lipid metabolism, oxidative stress, mitochondrial dysfunction, and protein changes caused by DM are associated with an impaired insulin signal pathway. These metabolic factors could increase the prevalence of AD in diabetic patients via the promotion of Aβ pathology.

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Section: Protein Changes In Ad and Dmmentioning

confidence: 99%

Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease

Sun

et al. 2020

Journal of Diabetes Research

119

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“…The use of heamatological indices in establishing the harmful effects of xenobiotics has been reported [36]. Reduction of packed cell volume (aneamia) associated with diabetes mellitus has been attributed to increase in nonenzymatic glycosylation of RBC membrane proteins.…”

Section: Discussionmentioning

confidence: 99%

<i>Brillantasia patula</i> Aqueous Leaf Extract Averts Hyperglycermia, Lipid Peroxidation, and Alterations in Hematological Parameters in Alloxan-Induced Diabetic Rats

Anigboro¹,

Avwioroko²,

Tonukari³

2018

IJBSE

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The protective effects of aqueous leaf extract of Brillantasia patula against hyperglycermia, lipid peroxidation, and alterations in hematological parameters in diabetic Wistar rats were investigated. The study consisted of six treatment groups, with five animals each, designated as Group-1 (healthy), Group-2 (diabetic control) and Groups 3-6 (diabetic rats treated with 500, 1000, 1500, and 2000 mg/kgbwt of extract, respectively). Rats were administered their respective doses orally, and daily, for 14 days. Thereafter, the effects on serum glucose levels, liver and kidney functions, lipid peroxidation, free radical scavenger and hematological parameters were analyzed. Blood glucose levels reduced markedly in diabetic rats given the plant extract relative to diabetic control. Both serum creatinine and urea decreased significantly in treated diabetic rats at extract doses of 1000 mg/kgbwt and above. Reductions in serum cholesterol (p<0.05) and triglyceride levels (p<0.05) were also observed. Elevated total serum protein and globulin in diabetic control was decreased in all treated groups. Haematological indices of groups given the extract were noticeably enhanced. Similarly, kidney, heart and liver glutathione (GSH) levels increased significantly in groups treated compared to diabetic control; lipid peroxidation in kidney and heart also decreased significantly in all the treated groups. Liver catalase activity improved. Serum alanine and aspartate aminotransferases activities widely lowered in Groups 3 and 4. The study indicates that Brillantaisia patula aqueous leaf extract exhibits potential hypoglycemic effect, prevents lipid peroxidation, boosts haematological parameters, and could protect liver and renal damage associated with diabetes especially at doses of 500 -1000 mg/kgbwt.

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“…The extraction of ZA was performed according to the method described by Ren et al (2017) and its HPLC chromatogram is shown in…”

Section: Materials and Chemicalsmentioning

confidence: 99%

“…Z. bungeanum, a cooking sauce, is one of the eight traditional condiments in China that involves a tingling sensation as part of the taste profile. The primary factor for tongue numbness in Z. bungeanum is Zanthoxylum alkylamides (ZA) which include α, γ, β-sanshool and their homologues with a hydroxy in the amino portion (Mei, 2012;Ren et al, 2017;Xu et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have mainly focused on the effect of ZA on lipid and carbohydrate metabolism but rarely on amino acid and protein metabolism. Ren et al (2017) studied the effect of ZA on the levels of amino acids and amino acid carrier mRNA in healthy SD rats, and although their findings suggested that ZA could promote the levels of glycogenic amino acids in plasma and skeletal muscle and could also facilitate the transportation of amino acids in the jejunum, the effect of ZA on amino acids and the corresponding carriers in T2DM rats is still unclear. Therefore, our goal in this study was to explore the effect of ZA on the disorder of amino acid metabolism in T2DM rats induced by a high fat and sugar diet combined with streptozotocin (STZ) injection.…”

Section: Introductionmentioning

confidence: 99%

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Zanthoxylum alkylamides improve amino acid metabolism in type 2 diabetes mellitus rats

et al. 2020

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To investigate the effect of Zanthoxylum alkylamides (ZA) on amino acid metabolism of type 2 diabetes mellitus (T2DM), the present study was performed with T2DM rats model induced with high fat and sugar fodder combined with low-dose of streptozotocin. ZA were fed to rats at three different doses of 2, 4, and 8 mg/kg for 28 days and metformin was fed to rats at 135 mg/kg as positive control. The results showed that compared with the normal control, the amino acid levels and the expression of related carrier genes were disordered in T2DM rats. Compared with the model, different doses of ZA could significantly resist (p < .05) the decrease in body weight of T2DM rats and improve hyperglycemia, with the best result observed with the high dose (8 mg/kg). Different doses of ZA could ameliorate the levels of 19 kinds of amino acid in the plasma, jejunum, liver, and skeletal muscle of T2DM rats by regulating the expression of related amino acid transporters including LAT1, SNAT2, CAT1, et al. to thereby ameliorating amino acid metabolism disorder in T2DM rats. Practical applications Previous studies showed that Zanthoxylum alkylamides (ZA) could promote the amino acid metabolism in the jejunum of healthy SD rats, improve protein metabolism disorder of type 1 diabetic rats, and also reduce the risk of metabolic syndrome in fat rats model. Herein, we investigated the effect of ZA on amino acid metabolism in type 2 diabetes mellitus (T2DM) rats. The results indicated that ZA could remarkably improve the abnormal expression of amino acid carriers in the jejunum, liver, and skeletal muscle, thereby ameliorating the disorder of amino acid metabolism in the plasma, jejunum, liver, and skeletal muscle of T2DM rats. Therefore, ZA are potential antidiabetic food/medicine product for the T2DM treatment.

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Zanthoxylum alkylamides ameliorate protein metabolism disorder in STZ-induced diabetic rats

Cited by 34 publications

References 51 publications

Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease

Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease

<i>Brillantasia patula</i> Aqueous Leaf Extract Averts Hyperglycermia, Lipid Peroxidation, and Alterations in Hematological Parameters in Alloxan-Induced Diabetic Rats

Zanthoxylum alkylamides improve amino acid metabolism in type 2 diabetes mellitus rats

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Zanthoxylum alkylamides ameliorate protein metabolism disorder in STZ-induced diabetic rats

Cited by 34 publications

References 51 publications

Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease

Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease

&lt;i&gt;Brillantasia patula&lt;/i&gt; Aqueous Leaf Extract Averts Hyperglycermia, Lipid Peroxidation, and Alterations in Hematological Parameters in Alloxan-Induced Diabetic Rats

Zanthoxylum alkylamides improve amino acid metabolism in type 2 diabetes mellitus rats

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<i>Brillantasia patula</i> Aqueous Leaf Extract Averts Hyperglycermia, Lipid Peroxidation, and Alterations in Hematological Parameters in Alloxan-Induced Diabetic Rats