ZHO-1, an intrinsic MBL from the environmental Gram-negative species Zhongshania aliphaticivorans

Kieffer, Nicolas; Guzmán-Puche, Julia; Poirel, Laurent; Kang, Hyo Jung; Jeon, Che Ok; Nordmann, Patrice

doi:10.1093/jac/dkz057

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…According to a Swiss study in 2019, the environmental Gram-negative organism Zhongshania aliphaticivorans, which lives in marine sediments, was shown to produce ZHO-1. This is an intrinsic carbapenemase with significant hydrolytic activity against most β-lactams including penicillins, cephalosporins, and carbapenems, with the exception of aztreonam and cefepime [272]. Another Swiss study, also in 2019, recognized the environmental Gram-negative species Pseudobacteriovorax antillogorgiicola to harbor PAN-1, which is an MBL with hydrolytic activity toward most β-lactams including carbapenems but not cefepime and aztreonam [273].…”

Section: Other Gram-negative Organismsmentioning

confidence: 99%

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The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

2020

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Carbapenemases are β-lactamases belonging to different Ambler classes (A, B, D) and can be encoded by both chromosomal and plasmid-mediated genes. These enzymes represent the most potent β-lactamases, which hydrolyze a broad variety of β-lactams, including carbapenems, cephalosporins, penicillin, and aztreonam. The major issues associated with carbapenemase production are clinical due to compromising the activity of the last resort antibiotics used for treating serious infections, and epidemiological due to their dissemination into various bacteria across almost all geographic regions. Carbapenemase-producing Enterobacteriaceae have received more attention upon their first report in the early 1990s. Currently, there is increased awareness of the impact of nonfermenting bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa, as well as other Gram-negative bacteria that are carbapenemase-producers. Outside the scope of clinical importance, carbapenemases are also detected in bacteria from environmental and zoonotic niches, which raises greater concerns over their prevalence, and the need for public health measures to control consequences of their propagation. The aims of the current review are to define and categorize the different families of carbapenemases, and to overview the main lines of their spread across different bacterial groups.

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Section: Other Gram-negative Organismsmentioning

confidence: 99%

“…Marine sediments Zhongshania aliphaticivorans ZHO-1 [272] Soft coral Pseudobacteriovorax antillogorgiicola PAN-1 [273] NDM = New Delhi metallo-β-lactamase. IMP = imipenemase.…”

Section: Gram-negative Environmental Speciesmentioning

confidence: 99%

The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

2020

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“…This similarity challenges the classification of the serine-dependent enzymes and the metal-dependent enzymes found in marine bacteria. When such enzymes are purified and annotated as β-lactamases (and often as having an ancient heritage) [ 148 , 149 , 150 , 151 , 152 ], is the basis for their heritage that of β-lactam resistance or that of quorum quenching [ 153 ]? Selleck et al suggest credibly that lactonase/lactamase promiscuity may offer an evolutionary advantage [ 153 ].…”

Section: Does the Marine Environment Contain β-Lactam-degrading Enzymes?mentioning

confidence: 99%

β-Lactams from the Ocean

Fisher

Mobashery

2023

Marine Drugs

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The title of this essay is as much a question as it is a statement. The discovery of the β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if not exclusively) secondary metabolites of terrestrial fungi and bacteria, transformed modern medicine. The antibiotic β-lactams inactivate essential enzymes of bacterial cell-wall biosynthesis. Moreover, the ability of the β-lactams to function as enzyme inhibitors is of such great medical value, that inhibitors of the enzymes which degrade hydrolytically the β-lactams, the β-lactamases, have equal value. Given this privileged status for the β-lactam ring, it is therefore a disappointment that the exemplification of this ring in marine secondary metabolites is sparse. It may be that biologically active marine β-lactams are there, and simply have yet to be encountered. In this report, we posit a second explanation: that the value of the β-lactam to secure an ecological advantage in the marine environment might be compromised by its close structural similarity to the β-lactones of quorum sensing. The steric and reactivity similarities between the β-lactams and the β-lactones represent an outside-of-the-box opportunity for correlating new structures and new enzyme targets for the discovery of compelling biological activities.

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“…The NDM-1 can be conveyed to human intestinal normal flora, further compounding the problem [10], and in connection to these antibiotics prescribed for humans can change the overall natural inhabitants of human intestinal flora [11,12]. The accumulative effects of the aforementioned environmental and health factors along with the emergence of other Carbapenem-resistant gramnegative bacteria such as the non-fermentative Carbapenem-resistant Pseudomonas aeruginosa (CRPA) [13] in the ICU led to a desperate search for solutions to the challenge of treating (MDR-GNB).…”

Section: Introductionmentioning

confidence: 99%

Detection of Potential ESBL, Ampc, and Metallo-Beta-Lactamase Producers (MDR-GNB) Through In-vitro Susceptibility Testing of Genitourinary Specimens in a Community-based Pilot Study

Abed¹,

Jusmani²,

Alrifai³

2021

Proceedings of the 1st International Ninevah Conference on Medical Sciences (INCMS 2021)

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This is a pilot study, which is intended to represent a basis for future studies pertinent to multidrug-resistant antimicrobial gram-negative (MDR-GNB) bacteria that commonly prevail in Iraqi community and hospital settings.In the present study, we scrutinize the antimicrobial phenotypic resistant patterns of commonly isolated Enterobacteriaceae (i.e., E. coli, E. aerogenes, K. oxytoca, P. mirabilis) from urine, wound samples, and high vaginal swabs in the Iraqi community. One hundred fifty-six (156) urine, genital lesions, and high vaginal swab samples were obtained from a community population in a cross-sectional study held in Baghdad at a private Lab from December 2020 to the end of April 2021. These specimens were isolated and identified according to conventional methods. Antimicrobial sensitivity tests were done according to the Kirby-Bauer method, and interpretation of results was made with reference to CLSI Standards for Antimicrobial Susceptibility Testing. Gram-negative bacilli were isolated from 80 (about 51%) of genitourinary specimens sent to the laboratory for culture and sensitivity. E. coli and E. aerogenes showed the most frequent bacterial isolate in genitourinary samples (60% and 31.25%, respectively). Complete resistance (i.e. 100%) to Amoxicillin-Clavulanic acid and Cefotaxime and high resistance (i.e. 97.5%) to Cefixime, Ceftriaxone, and Ceftazidime by these bacterial strains were observed. Assessment of Enterobacteriaceae antibiotic resistance for both of ß-lactams and Carbapenems showed that 25% of these strains were having resistance to both groups of antibiotics. As a conclusion; Enterobacteriaceae multi-drug resistance reflects potential ESBL, Ampc, and carbapenemase activity in Iraq.

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ZHO-1, an intrinsic MBL from the environmental Gram-negative species Zhongshania aliphaticivorans

Cited by 6 publications

References 10 publications

The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria

β-Lactams from the Ocean

Detection of Potential ESBL, Ampc, and Metallo-Beta-Lactamase Producers (MDR-GNB) Through In-vitro Susceptibility Testing of Genitourinary Specimens in a Community-based Pilot Study

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