2016
DOI: 10.4269/ajtmh.16-0323
|View full text |Cite
|
Sign up to set email alerts
|

Zika Virus and Chikungunya Virus CoInfections: A Series of Three Cases from a Single Center in Ecuador

Abstract: Zika virus (ZIKV) and chikungunya virus (CHIKV) cocirculate throughout much of the tropical Western Hemisphere; however, few cases of coinfection with these two pathogens have been reported. Herein, we describe three cases of ZIKV-CHIKV coinfection detected at a single center in Ecuador: a patient who developed symptoms on postoperative day 5 from an orthopedic procedure, a woman who had traveled to Ecuador for fertility treatment, and a woman who was admitted for Guillain-Barré syndrome and had ZIKV and CHIKV… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

4
62
0
1

Year Published

2016
2016
2019
2019

Publication Types

Select...
8
1

Relationship

2
7

Authors

Journals

citations
Cited by 77 publications
(67 citation statements)
references
References 15 publications
4
62
0
1
Order By: Relevance
“…This figure is consistent with our earlier findings, which included a subset of patients from this analysis, as well as those from Guayaquil, Ecuador, where the ZCD assay has also been implemented [6, 28]. The apparent difference in rates of coinfection may then result from a number of factors, including a reliance on serological testing in many endemic areas; the performance of individual tests for each virus, which increases test cost and may decrease utilization; and a lack of signs or symptoms that clinically distinguish co-infections from monoinfections.…”
Section: Discussionsupporting
confidence: 92%
“…This figure is consistent with our earlier findings, which included a subset of patients from this analysis, as well as those from Guayaquil, Ecuador, where the ZCD assay has also been implemented [6, 28]. The apparent difference in rates of coinfection may then result from a number of factors, including a reliance on serological testing in many endemic areas; the performance of individual tests for each virus, which increases test cost and may decrease utilization; and a lack of signs or symptoms that clinically distinguish co-infections from monoinfections.…”
Section: Discussionsupporting
confidence: 92%
“…Clinical features of the disease are similar to those of other viral, protozoan, and bacterial diseases previously reported in Ecuador ( 1 , 4 , 8 , 9 ). OROV might spread unnoticed across a wide geographic area, as suggested by this unexpected detection.…”
supporting
confidence: 81%
“…GBS has been the best studied neurological presentation in adults, and the association between recent ZIKV infection and GBS has been principally demonstrated in studies that have relied on serologic testing for ZIKV diagnosis (Cao-Lormeau et al, 2016; Dos Santos et al, 2016). This may be due to difficulties in diagnosing acute ZIKV infections in adults, as detection of ZIKV in CSF has been infrequently reported (Parra et al, 2016; Rozé et al, 2016; Siu et al, 2016; Zambrano et al, 2016) and serologic testing may be difficult to interpret in DENV endemic regions (Waggoner and Pinsky, 2016). …”
Section: Introductionmentioning
confidence: 99%
“…Clinical diagnosis cannot reliably distinguish symptomatic infections caused by these viruses (Waggoner et al, 2016b), which complicates the interpretation of results from studies based on reported Zika cases (Dos Santos et al, 2016) or patients with compatible symptoms (Parra et al, 2016). Additionally, co-infections between these viruses may be common in certain settings (Villamil-Gomez et al, 2016; Waggoner et al, 2016b; Zambrano et al, 2016), and the detection of co-infections in cases of CNS disease has not been well described (Zambrano et al, 2016). …”
Section: Introductionmentioning
confidence: 99%