Zika Virus Infection Associated with Autism Spectrum Disorder: A Case Report

Santi, Lucélia; Riesgo, Rudimar dos Santos; Quincozes‐Santos, André; Schüler‐Faccini, Lavínia; Tureta, Emanuela Fernanda; Rosa, Rafael Lopes da; Berger, Markus; Oliveira, Avessandra Costa Cardoso de; Beltrão-Braga, Patrícia Cristina Baleeiro; Souza, Diogo Onofre Gomes de; Guimarães, Jorge A.; Beys‐da‐Silva, Walter O.

doi:10.1159/000516560

Cited by 11 publications

(8 citation statements)

References 20 publications

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“…According to a database of imaging studies, cranial characteristics of children with microcephaly were described, including a substantial increase in ventricle volumes, cortical and subcortical atrophy, cerebellar hypoplasia and abnormalities in the white matter, corpus callosum, basal ganglia, and trunk, as well as calcifications in different brain regions (Schuler‐Faccini et al, 2022; Wu et al, 2018). Moreover, diagnosis of autism spectrum disorders (ASD) in childhood were recently correlated with ZIKV infection during pregnancy (Santi et al, 2021; Vianna et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The role of glial cells in Zika virus‐induced neurodegeneration

Quincozes‐Santos

Bobermin

Costa

et al. 2023

Glia

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Zika virus (ZIKV) is a strongly neurotropic flavivirus whose infection has been associated with microcephaly in neonates. However, clinical and experimental evidence indicate that ZIKV also affects the adult nervous system. In this regard, in vitro and in vivo studies have shown the ability of ZIKV to infect glial cells. In the central nervous system (CNS), glial cells are represented by astrocytes, microglia, and oligodendrocytes. In contrast, the peripheral nervous system (PNS) constitutes a highly heterogeneous group of cells (Schwann cells, satellite glial cells, and enteric glial cells) spread through the body. These cells are critical in both physiological and pathological conditions; as such, ZIKV-induced glial dysfunctions can be associated with the development and progression of neurological complications, including those related to the adult and aging brain. This review will address the effects of ZIKV infection on CNS and PNS glial cells, focusing on cellular and molecular mechanisms, including changes in the inflammatory response, oxidative stress, mitochondrial dysfunction, Ca 2+ and glutamate homeostasis, neural metabolism, and neuron-glia communication. Of note, preventive and therapeutic strategies that focus on glial cells may emerge to delay and/or prevent the development of ZIKV-induced neurodegeneration and its consequences.André Quincozes-Santos and Larissa Daniele Bobermin contributed equally to this work.

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Section: Introductionmentioning

confidence: 99%

The role of glial cells in Zika virus‐induced neurodegeneration

Quincozes‐Santos

Bobermin

Costa

et al. 2023

Glia

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“…To date, organoid models have been successfully applied to study events of neural precursor cell dysfunction occurring in the early stages of brain development, including precursor cell abnormalities of Zika virus infection and its resulting microcephaly‐related phenotypes, 59,60 which were the first developmental disorders to be studied in organoids 7 . The use of organoids successfully revealed that the Zika virus disrupts the apical junctions of radial glial cells (RGCs) through the protein NS2A, 61 causing RGCs to proliferate less, produce fewer neurons, and produce apoptosis, 9,62 leading to disruption of ventricular zone structures and RGC scaffolds and tissue structural disruption, 63 ultimately producing a microcephalic phenotype 64,65 .…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

Bibliometric analysis of cerebral organoids and diseases in the last 10 years

Luo,

Liu,

Fan

2023

Ibrain

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Cerebral organoids have emerged as a powerful tool for mirroring the brain developmental processes and replicating its unique physiology. This bibliometric analysis aims to delineate the burgeoning trends in the application of cerebral organoids in disease research and offer insights for future investigations. We screened all relevant literature from the Web of Science on cerebral organoids in disease research during the period 2013–2022 and analyzed the research trends in the field using VOSviewer, CiteSpace, and Scimago Graphica software. According to the search strategy, 592 articles were screened out. The United States of America (USA) was the most productive, followed by China and Germany. The top nine institutions in terms of the number of publications include Canada and the United States, with the University of California, San Diego (USA), having the highest number of publications. The International Journal of Molecular Sciences was the most productive journal. Knoblich, Juergen A., and Lancaster, Madeline A. published the highest number of articles. Keyword cluster analysis showed that current research trends focused more on induced pluripotent stem cells to construct organoid models of cerebral diseases and the exploration of their mechanisms and therapeutic modalities. This study provides a comprehensive summary and analysis of global research trends in the field of cerebral organoids in diseases. In the past decade, the number of high‐quality papers in this field has increased significantly, and cerebral organoids provide hope for simulating nervous system diseases (such as Alzheimer's disease).

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“…Recently a cohort analyzed in an in utero exposed children has presented 2.1% of individuals diagnosed with autism ( Nielsen-Saines et al, 2019 ). Although the limitations of this cited report cannot ensure that ZIKV infection is responsible for the disease, our group reported a child diagnosed with autism presented the exposure to ZIKV in utero as the only abnormality among all known molecular and genetic causes for autism ( Santi et al, 2021 ). Amyotrophic lateral sclerosis (ALS) and AD have presented an expressive number of genes in the neurodegenerative diseases group, followed by Parkinson’s disease (PD) and multiple sclerosis ( Figure 6B ).…”

Section: Mechanisms: Lessons From Experimental Studiesmentioning

confidence: 97%

Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects

et al. 2022

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Five years after the identification of Zika virus as a human teratogen, we reviewed the early clinical manifestations, collectively called congenital Zika syndrome (CZS). Children with CZS have a very poor prognosis with extremely low performance in motor, cognitive, and language development domains, and practically all feature severe forms of cerebral palsy. However, these manifestations are the tip of the iceberg, with some children presenting milder forms of deficits. Additionally, neurodevelopment can be in the normal range in the majority of the non-microcephalic children born without brain or eye abnormalities. Vertical transmission and the resulting disruption in development of the brain are much less frequent when maternal infection occurs in the second half of the pregnancy. Experimental studies have alerted to the possibility of other behavioral outcomes both in prenatally infected children and in postnatal and adult infections. Cofactors play a vital role in the development of CZS and involve genetic, environmental, nutritional, and social determinants leading to the asymmetric distribution of cases. Some of these social variables also limit access to multidisciplinary professional treatment.

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Zika Virus Infection Associated with Autism Spectrum Disorder: A Case Report

Cited by 11 publications

References 20 publications

The role of glial cells in Zika virus‐induced neurodegeneration

The role of glial cells in Zika virus‐induced neurodegeneration

Bibliometric analysis of cerebral organoids and diseases in the last 10 years

Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects

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