Zinc and copper oxide nanoparticles decrease synaptosomal glutamate uptake: an in vitro study

Rafiei, Shahrbanoo; Riazi, Gholamhossein; Afrasiabi, Ali; Dadras, Ali; Khajeloo, Mojtaba; Shahriary, Leila; Eskandari, Ghazaleh; Modaresi, Seyed Mohamad Sadegh

doi:10.1007/s13738-014-0458-y

Cited by 9 publications

(4 citation statements)

References 61 publications

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“…Even though the molecular toxicity mechanisms of CUNPs on eukaryotic cells are unclear, many studies have shown that these nanoparticles promote mitochondrial damage, DNA damage, and oxidative DNA damage. 58,59 These results showed that CUNPs were more toxic than Cu 21 because of the generation of ROS, DNA damage, and decreased levels of reduced glutathione (GSH) compared with those of control cells. The mechanism of toxicity of CUNPs in the cellular membrane was suggested by Grigore et al 11 through a mechanism similar to those of Trojan horse-type.…”

Section: Specific Activity Of Adenosine Deaminasementioning

confidence: 99%

Biogenic synthesis of copper oxide nanoparticles using olea europaea leaf extract and evaluation of their toxicity activities: An in vivo and in vitro study

Sulaiman

Tawfeeq

Jaaffer

2017

Biotechnology Progress

114

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Copper oxide nanoparticles (CUNPs) were synthesized using Olea europaea leaf extract as reducing and protecting agent. The formation of nanoparticles was observed through a color change from yellowish to brownish black. The CUNPs were confirmed with UV-Vis spectrophotometer, which revealed a peak absorbance at 289 nm. The synthesized CUNPs were characterized by XRD, FTIR, SEM, and TEM. The XRD pattern revealed that CUNPs were crystalline in nature with a diameter around 20 nm. FTIR spectral analysis showed that CUNPs were capped with plant constituents. From SEM and TEM analyses, the CUNPs were generally found to be spherical in shape, and the size range was 20-50 nm. Free radical scavenging potential of CUNPs against DPPH was confirmed by its stable antioxidant effects. In addition, the toxicity of CUNPs in mice was also assessed by body weight and weights of liver, kidneys, spleen, and thymus. The immune response in mice was signaled through an obvious change in spleen and thymus index, with a decrease of ADA enzyme activity in serum, spleen, and thymus after CUNPs treatment. The CUNPs were found to exert cell growth arrest against AMJ-13 and SKOV-3 cancer cells in a dose-dependent manner and induce cell death by apoptosis. Less significant cytotoxic effect was observed in normal dermal fibroblast cells. These findings suggest that CUNPs may have the potential to be anticancer agents. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 34:218-230, 2018.

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Section: Specific Activity Of Adenosine Deaminasementioning

confidence: 99%

Biogenic synthesis of copper oxide nanoparticles using olea europaea leaf extract and evaluation of their toxicity activities: An in vivo and in vitro study

Sulaiman

Tawfeeq

Jaaffer

2017

Biotechnology Progress

114

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“…Rafiei et al reported that CuO NPs induced oxidative stress in various cultured cells [65]. Also, Karlsson et al reported that the oxidative stress induced by CuO ions could also support its genotoxicity [66].…”

Section: Medical Applicationsmentioning

confidence: 99%

Methods of Synthesis, Properties and Biomedical Applications of CuO Nanoparticles

et al. 2016

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This study aims to provide an updated survey of the main synthesis methods of copper oxide (CuO) nanoparticles in order to obtain tailored nanosystems for various biomedical applications. The synthesis approach significantly impacts the properties of such nanoparticles and these properties in turn have a significant impact on their biomedical applications. Although not widely investigated as an efficient drug delivery system, CuO nanoparticles have great biological properties including effective antimicrobial action against a wide range of pathogens and also drug resistant bacteria. These properties have led to the development of various approaches with direct applications to the biomedical field, such as tailored surfaces with antimicrobial effect, wound dressings and modified textiles. It is also believed that these nanosystems could represent efficient alternatives in the development of smart systems utilized both for the detection of pathogens and for the treatment of infections.

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“…CuO-NPs display adequately more toxicity for mortal lung cultivated cells for mortal dermal organ cultivations in correlation to their micro-ranged replacements [63,64]. Rafiei et al unveiled that the NPs initiated oxidative stress in numerous cultivated locules [65]. Similarly, Karlsson et al proclaimed that the initialised oxidative stress with ions of CuO can additionally assist the genotoxicity [66].…”

Section: Toxicity Of Cuo-npsmentioning

confidence: 99%

Strategies to synthesise copper oxide nanoparticles and their bio applications – a review

Khatoon

Mantravadi

Rao

2018

Materials Science and Technology

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Researchers have identified copper oxide nanoparticles (CuO-NPs) as a key of interest because of their unique shape- and size-dependent bio-medical properties. Researchers have discovered and invented a variety of methods for the synthesis of CuO-NPs under physical, chemical and biological approach. In this review paper, we give an overview of the preparation of CuO-NPs through various methods and also their applications in the bio-medical field. The main aim of this paper is to keep up to date with the myriad ongoing methods of NPs’ synthesis and also examine their applications, especially in the field of medicine.

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Zinc and copper oxide nanoparticles decrease synaptosomal glutamate uptake: an in vitro study

Cited by 9 publications

References 61 publications

Biogenic synthesis of copper oxide nanoparticles using olea europaea leaf extract and evaluation of their toxicity activities: An in vivo and in vitro study

Biogenic synthesis of copper oxide nanoparticles using olea europaea leaf extract and evaluation of their toxicity activities: An in vivo and in vitro study

Methods of Synthesis, Properties and Biomedical Applications of CuO Nanoparticles

Strategies to synthesise copper oxide nanoparticles and their bio applications – a review

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