Zinc carnosine: Frontiers advances of supplement for cancer therapy

Tang, Weiwei; Liu, Hanyuan; Ooi, Theng Choon; Rajab, Nor Fadilah; Cao, Hongxin; Sharif, Razinah

doi:10.1016/j.biopha.2022.113157

Cited by 13 publications

(11 citation statements)

References 61 publications

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“…Oral mucositis is frequently accompanied by pain, odynophagia, xerostomia, and dysgeusia, and it can lead to malnutrition, dehydration, and lowers the patients' quality of life significantly (QoL) [5]. Polaprezinc (PZ), a chelated form of zinc and L-carnosine, inhibits the production of inflammatory cytokines such as tumour necrosis factoralpha (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6) and matrix metalloproteinase-2 (MMP-2) and induces an anti-inflammatory effect and immune responses via inhibition of nuclear factor-kappa-light-chain-enhancer of activated B cells (NF-κB) [5,6].…”

Section: Role Of L-carnosine In Cancermentioning

confidence: 99%

Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis

Sureshkumar¹,

Durairaj²,

Srinivasan³

et al. 2023

Front. Biosci. (Landmark Ed)

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Introduction: L-carnosine has been found to have multimodal activity. Aim: The aim of this review was to find out the efficacy of Lcarnosine in patients with age-related diseases. Methods: Clinical studies evaluated the effect of L-carnosine on cancer, cardiovascular disease, diabetes, and neurodegenerative disorders were searched in electronic bibliographic databases. The protocol has been registered with PROSPERO (CRD42022314033). The revised Cochrane risk of bias tool for randomized trials was used to assess all of the reports for risk of bias. RevMan 5.4 was used to conduct the meta-analysis. Results: Following the screening process, 14 papers were selected for systematic review, with 9 of them being qualified for meta-analysis. Many of the included studies showed that L-carnosine has potential therapeutic activity in age related diseases. Results from the meta-analysis showed that in diabetes mellitus, HbA1c [mean difference (MD) 95% CI = -1.25 (-2.49, -0.022); p = 0.05; p = 0.001; I 2 = 85%] and fasting blood sugar (FBS) [MD 95% CI = -12.44 (-22.44, -2.44); p = 0.01; p = 0.40; I 2 = 0%] and in neurodegenerative disorder, Wechsler Memory Scale Logical Memory 2 (WMS-LM2) [MD 95% CI = 1.34 (0.83, 1.85); p < 0.00001; p = 0.43; I 2 = 0%], showed statistically significant difference, favoring the L-carnosine group over the control group. While in neurodegenerative disorder, Alzheimer 's Disease Assessment Scale (ADAS) [MD 95% CI = 0.98 (-1.55, -0.42); p = 0.0007; p = 0.86; I 2 = 0%] and Back Depression Inventory (BDI) [MD 95% CI = -1.12 (-1.87, -0.37); p = 0.003; p = 0.73; I 2 = 0%] showed statistically significant difference, favoring the control group over L-carnosine group. Conclusions: Clinical studies were conducted to manage chemotherapy induced toxicities and there are no clinical studies available for its anti-cancer use, and the current evidence does not support its use in the treatment of cardiovascular disease.

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Section: Role Of L-carnosine In Cancermentioning

confidence: 99%

Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis

Sureshkumar¹,

Durairaj²,

Srinivasan³

et al. 2023

Front. Biosci. (Landmark Ed)

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“…Zinc is the second most abundant micronutrient in humans and plays critical roles in many general cellular functions ( 1 ). The distribution, regulation, and crosstalk of these micronutrients are widely involved in various physiological and pathological processes ( 2 – 4 ). The significance of zinc for health has been paid more and more attention because its deficiency may lead to many diseases, such as anorexia, loss of appetite, smell and taste disorders, and other disorders ( 4 – 6 ).…”

Section: Introductionmentioning

confidence: 99%

“…The relationship between zinc and tumor has been intensively investigated in experimental and human studies over decades ( 4 , 7 , 8 ). For example, many studies demonstrated reduced zinc levels in different cancers and the corresponding downregulation of zinc importers and the upregulation of zinc exporters ( 7 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the zinc supplement therapeutic method has been proven to be good tumor adjuvant therapy. For example, zinc-L-carnosine, which refers to one chelation-based compound containing L-carnosine as well as zinc, showed a well-alleviating effect on the side-effects of cancer treatment ( 4 , 13 ). ZnO nano-scale particles were able to target multiple cell types of carcinoma, covering carcinoma cells, carcinoma stem cells, and macrophages, and simultaneously perform a number of vital roles, including limitation of carcinoma proliferating process, sensitization of drug-resistant carcinoma, prevention of carcinoma recurrence and metastasis, and resuscitation of carcinoma immunosurveillance ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

“…Zinc is the second most abundant micronutrient in humans and plays critical roles in many general cellular functions (1). The distribution, regulation, and crosstalk of these micronutrients are widely involved in various physiological and pathological processes (2)(3)(4). The significance of zinc for health Liu et al 10.3389/fnut.2022.960926 has been paid more and more attention because its deficiency may lead to many diseases, such as anorexia, loss of appetite, smell and taste disorders, and other disorders (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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Chicken skin-derived collagen peptides chelated zinc promotes zinc absorption and represses tumor growth and invasion in vivo by suppressing autophagy

Liu

Zou²,

Ji³

et al. 2022

Front. Nutr.

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To improve the utilization value of chicken by-products, we utilized the method of step-by-step hydrolysis with bromelain and flavourzyme to prepare low molecular weight chicken skin collagen peptides (CCP) (<5 kDa) and characterized the amino acids composition of the CCP. Then, we prepared novel CCP-chelated zinc (CCP–Zn) by chelating the CCP with ZnSO4. We found that the bioavailability of CCP–Zn is higher than ZnSO4. Besides, CCP, ZnSO4, or CCP–Zn effectively repressed the tumor growth, invasion, and migration in a Drosophila malignant tumor model. Moreover, the anti-tumor activity of CCP–Zn is higher than CCP or ZnSO4. Furthermore, the functional mechanism studies indicated that CCP, ZnSO4, or CCP–Zn inhibits tumor progression by reducing the autonomous and non-autonomous autophagy in tumor cells and the microenvironment. Therefore, this research provides in vivo evidence for utilizing chicken skin in the development of zinc supplements and cancer treatment in the future.

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Dietary zinc supplements: beneficial health effects and application in food, medicine and animals

Shi,

Hao,

et al. 2024

J Sci Food Agric

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Zinc, a crucial trace element is vital for the growth and development of humans. It is frequently described as ‘the flower of life’ and ‘the source of intelligence’. Zinc supplements play a pivotal role in addressing zinc deficiency by serving as a vital source of this essential micronutrients, effectively replenishing depleted zinc levels in the body. In this paper, we first described the biological behavior of zinc in the human body and briefly described the physiological phenomena associated with zinc levels. The benefits and drawbacks of various zinc supplement forms are then discussed, with emphasis on the most recent zinc supplement formulations. Finally, the application of zinc supplements in food, medicine, and animal husbandry is further summarized. © 2024 Society of Chemical Industry.

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Zinc carnosine: Frontiers advances of supplement for cancer therapy

Cited by 13 publications

References 61 publications

Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis

Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis

Chicken skin-derived collagen peptides chelated zinc promotes zinc absorption and represses tumor growth and invasion in vivo by suppressing autophagy

Dietary zinc supplements: beneficial health effects and application in food, medicine and animals

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