Zinc Homeostasis in Bone: Zinc Transporters and Bone Diseases

Huang, Tongling; Yan, Guoyong; Guan, Min

doi:10.3390/ijms21041236

Cited by 78 publications

(41 citation statements)

References 93 publications

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“…It has a wide array of vital physiological functions. For example, it is necessary for the functional and structural integrity of cells [ 74 ], for the anti-inflammatory response [ 75 ] and in bone homeostasis [ 76 ]. A deficiency in Zn levels has been associated with autism spectrum disorder (ASD) and in particular with more severe autism symptoms [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Fish-Based Baby Food Concern—From Species Authentication to Exposure Risk Assessment

et al. 2020

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In this work, two different but complementary approaches were used to evaluate the reliability of fish-based baby foods as a source of safe nourishment for babies. More specifically, barcoding analysis based on the Cytochrome Oxidase I sequences was used for fish species authentication and an analysis of metal/metalloid levels was performed to estimate the exposure risk assessment derived from consumption of selected fish-based baby food in infants and toddlers. COI DNA barcoding revealed that in three samples the species detected did not match the common name of the species shown on the label. In particular, G. chalcogrammus and M. australis were found in place of M. merluccius and O. mykiss was found in place of S. salar. The analysis of exposure risk assessment indicated a low risk for developing chronic systemic and carcinogenic effects in infants and toddler, under an exposure scenario based on daily consumption of a single box of fish-based baby food. However, it is important to highlight that in order to provide a comprehensive risk assessment it would be important to supplement the levels of exposure resulting from the total diet. Overall, our results suggest that more attention should be paid by authorities to ensure the safety of food for infants and toddlers.

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Section: Discussionmentioning

confidence: 99%

Fish-Based Baby Food Concern—From Species Authentication to Exposure Risk Assessment

et al. 2020

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“…A substantial proportion of zinc (~30%) is stored in bone, and the pathological reduction of zinc levels impairs bone growth. [17][18][19] Zinc plays an important regulatory role in bone formation. In addition to being a component of inorganic minerals, it also activates proteins involved in bone homeostasis.…”

Section: Introductionmentioning

confidence: 99%

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

Li¹,

Yang²,

Qing³

et al. 2020

IJN

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Prosthesis-associated infections and aseptic loosening are major causes of implant failure. There is an urgent need to improve the antibacterial ability and osseointegration of orthopedic implants. Zinc oxide nanoparticles (ZnO-NPs) are a common type of zinccontaining metal oxide nanoparticles that have been widely studied in many fields, such as food packaging, pollution treatment, and biomedicine. The ZnO-NPs have low toxicity and good biological functions, as well as antibacterial, anticancer, and osteogenic capabilities. Furthermore, ZnO-NPs can be easily obtained through various methods. Among them, green preparation methods can improve the bioactivity of ZnO-NPs and strengthen their potential application in the biological field. This review discusses the antibacterial abilities of ZnO-NPs, including mechanisms and influencing factors. The toxicity and shortcomings of anticancer applications are summarized. Furthermore, osteogenic mechanisms and synergy with other materials are introduced. Green preparation methods are also briefly reviewed.

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“…6,54 Zinc deficiency was shown to be associated with bone growth retardation, and an increase in zinc concentrations might be beneficial for the development, growth, and health of the bone. 55,56 (b) Our results did not indicate that the applied PBMT or ESWT influenced bone alterations considerably concerning the mechanical and elemental composition since the measured parameters of these groups did not change significantly compared to the BIS-treated positive controls that did not receive physical therapies (Fig. 7).…”

Section: Resultsmentioning

confidence: 67%