2006
DOI: 10.1111/j.1478-3231.2006.01352.x
|View full text |Cite
|
Sign up to set email alerts
|

Zinc is a negative regulator of hepatitis C virus RNA replication

Abstract: We demonstrated that zinc may play an important role as a negative regulator of HCV replication in genome-length HCV RNA-replicating cells. Zinc supplementation thus appears to offer a novel approach to the development of future strategies for the treatment of intractable chronic hepatitis C.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
33
0

Year Published

2008
2008
2024
2024

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 56 publications
(35 citation statements)
references
References 36 publications
2
33
0
Order By: Relevance
“…Several in vitro studies indicate that zinc may be able to inhibit viral replication of HCV [174], but also herpes simplex virus [77] and rhinovirus [74], all at concentrations of 100 µM zinc ions in the culture medium. For HIV, a concentration of 100 µg/ml (~1.5 mM) was effective [60].…”
Section: Viral Infectionsmentioning
confidence: 99%
“…Several in vitro studies indicate that zinc may be able to inhibit viral replication of HCV [174], but also herpes simplex virus [77] and rhinovirus [74], all at concentrations of 100 µM zinc ions in the culture medium. For HIV, a concentration of 100 µg/ml (~1.5 mM) was effective [60].…”
Section: Viral Infectionsmentioning
confidence: 99%
“…There are several potential mechanisms supporting the antioxidant effects of zinc, such as the decrease of hepatic fibrosis, antioxidant activity, down-regulation of ferritin, and improvement in hepatic encephalopathy. Zn also is able to decrease HCV replication, then it has been used as an adjuvant for treatment of HCV infection, but further studies are needed to understand the involved mechanisms [51] .…”
Section: Zincmentioning
confidence: 99%
“…On the other hand, several mechanisms have been suggested indicating that zinc may improve the response to standard anti-HCV pharmacotherapy. Antioxidant function, promotion of the antiviral effect of interferon, an inhibitory effect on HCV replication, and regulation of imbalances between T helper 1 (TH1) and T helper 2 (TH2) have been considered as probable mechanisms for the effectiveness of zinc in treatment of HCV infection [16,17]. In recent clinical studies, the addition of zinc to the standard treatment regimen for chronic hepatitis C produced limited benefits [8].…”
Section: Resultsmentioning
confidence: 99%