Zinc supplementation alleviates the progression of diabetic nephropathy by inhibiting the overexpression of oxidative-stress-mediated molecular markers in streptozotocin-induced experimental rats

Barman, Susmita; Pradeep, Seetur R.; Srinivasan, Krishnapura

doi:10.1016/j.jnutbio.2017.11.008

Cited by 36 publications

(23 citation statements)

References 51 publications

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“…Reactive oxygen species, oxidative stress, inflammation, enhanced production of advanced glycation end products and enhanced polyol pathway have been linked to the onset and progression of DN (Barman, Pradeep, & Srinivasan, 2018;Olatunji, Chen, & Zhou, 2018;Pan et al, 2010). The excessive generation of ROS resulting in oxidative stress induced by persistent hyperglycemia play a prominent role in DN.…”

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Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

et al. 2019

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In this present study, rhinacanthins‐rich extract (RRE) and rhinacanthin C (RC) the main bioactive constituent of Rhinacanthus nasutus was investigated for their protective effect against diabetic nephropathy (DN). Diabetes was induced by administering nicotinamide (100 mg/kg, i.p.)/streptozotocin (60 mg/kg, i.p.) and diabetic rats were orally administered with RRE and RC for 4 weeks. RRE and RC significantly reduced the kidney index, renal oxidative stress markers, and pro‐inflammatory cytokines. Furthermore, RRE and RC increased renal levels of glutathione, superoxide dismutase, catalase, and attenuated diabetic induced renal damages. In conclusion, RRE and RC confer protective effect against DN through the inhibition of oxidative stress and inflammation and could be a potential medicinal or nutritional supplement for the prevention of DN. Practical applications Rhinacanthus nasutus is a medicinal plant that is extensively used in Thai traditional medicine as an antibacterial, antifungal, antidiabetic, and anti‐inflammatory agent. The plant is rich in naphthoquinones, which confer it with several excellent bioactivities. The rich extract of the leaves was prepared with three major bioactive components and the extract was evaluated for its renoprotective effect in diabetic rats. The results from this study provides valuable pharmacological information that supports the use of the plant, especially the rich extract in the prevention and treatment of diabetes and diabetic complications.

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Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

et al. 2019

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“…Streptozotocin is widely used to induce diabetes because STZ-induced experimental diabetic rats exhibit well-characterized diabetic complications and sustained hyperglycemia with a low incidence of mortality [ 12 – 14 ]. Here, STZ-induced diabetes rats were constructed to investigate the potential role of AVP and RVP in the development of DN.…”

Section: Discussionmentioning

confidence: 99%

Over-expression of arginine vasopressin in magnocellular neurosecretory cells of hypothalamus and its potential relationship with development of diabetic nephropathy

Gao

et al. 2020

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Introduction: We aimed to assess our hypothesis that the expression changes of arginine vasopressin (AVP) in the magnocellular neurosecretory cells (MNCs) of hypothalamus and V2 receptor for AVP (RVP) in kidney may contribute to the pathogenesis of diabetic nephropathy (DN). Material and methods: Twenty-five male Wistar rats were randomly assigned to the control group and the diabetes mellitus (DM) group. Periodic acid-Schiff (PAS) staining and electron microscopy were used for morphological studies. Immunohistochemical staining for glial fibrillary acidic protein (GFAP) is standard for visualization of reactive astrocytes in the hypothalamus. Hypothalamus was used for immunofluorescence of AVP. Kidney was used for immunohistochemical staining of RVP. Quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) was used for quantitative determinations of AVP mRNA in hypothalamus and RVP mRNA in kidney. Western blot was used to measure the protein expression of AVP in hypothalamus and RVP in kidney. Results: Morphological studies showed abnormalities in kidney and hypothalamus in the DM group. The number of neurons and the gray value of astrocytes in hypothalamus in the DM group were markedly decreased. The expression level of AVP in hypothalamus and the expression level of RVP in kidney of DM rats were significantly increased. The positive correlations between the proteinuria and expression (mRNA and protein) of AVP, proteinuria and expression (mRNA and protein) of RVP, and the expression of AVP and RVP levels were found. Conclusions: AVP was upregulated in the MNCs of hypothalamus and RVP was upregulated in kidney in streptozotocin-induced DM rats, indicating their potential roles in the development of DN.

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“…The progression of DN involve several stages, such as glomerular hypertrophy, proteinuria, glomerulosclerosis, interstitial fibrosis, and renal failure (Li et al, 2019). Several potential mechanisms underlying DN development have been reported, including oxidative stress (Barman et al, 2018), inflammation (Olatunji et al, 2018), advanced glycation end products, and polyol pathway (Pan et al, 2010). However, there is still a lack of effective treatments for DN, so elucidating the mechanisms and discovering new drugs of DN treatment are urgently required.…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Basic Fibroblast Growth Factor on Diabetic Nephropathy Through Remodeling Metabolic Phenotype and Suppressing Oxidative Stress in Mice

et al. 2020

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Diabetic nephropathy is a common complication in diabetes, but still lack of effective therapeutic strategies. This study aimed to investigate the therapeutic effect of basic fibroblast growth factor (bFGF) in db/db mice with diabetic nephropathy and explore its possible metabolic mechanisms using a nuclear magnetic resonance-based metabolomic approach. We found that bFGF treatment significantly alleviate urinary albumin to creatinine ratio and renal fibrosis in db/db mice, suggesting a potential renal protective effect. Metabolomics results reveal that bFGF remodeled metabolic phenotypes of the kidney and urine in db/db mice, mainly involving energy metabolism, methylamine metabolism, osmoregulation, and oxidative stress. Furthermore, the results show that bFGF-induced reductions of oxidative stress and apoptosis in db/db mice might be mediated by NOX-ROS-Nrf2 signaling. Therefore, our study suggests that the protective effect of bFGF on diabetic nephropathy could be mediated by remodeling metabolic phenotype and suppressing oxidative stress.

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Zinc supplementation alleviates the progression of diabetic nephropathy by inhibiting the overexpression of oxidative-stress-mediated molecular markers in streptozotocin-induced experimental rats

Cited by 36 publications

References 51 publications

Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

Over-expression of arginine vasopressin in magnocellular neurosecretory cells of hypothalamus and its potential relationship with development of diabetic nephropathy

The Protective Effect of Basic Fibroblast Growth Factor on Diabetic Nephropathy Through Remodeling Metabolic Phenotype and Suppressing Oxidative Stress in Mice

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