Zinc Suppresses Apoptosis of U937 Cells Induced by Hydrogen Peroxide through an Increase of the Bcl-2/Bax Ratio

Testicular apoptosis after dietary zinc deficiency: Ultrastructural and TUNEL studies

“…The ability of Zn 2+ to prevent DNA fragmentation has been attributed to its inhibitory effect on Ca 2+ and Mg 2+ -dependent endonucleases Zhivotovsky et al 1994], although there are numerous targets of zinc in the apoptotic cascade such as caspase-3, caspase-6, bcl-2, p53, etc. [Takahashi et al 1996;Stennicke and Salvesen 1997;Wolf et al 1997;Fukamachi et al 1998;Chai et al 1999;Jankowski-Hennig et al 2000;Fanzo et al 2001;Ho and Ames 2002;Ho et al 2003], imbalance of either would lead to the initiation of apoptosis. Abnormally accelerated apoptosis of germ cells may lead to an imbalance of cell proliferation and death resulting in spermatogenic impairment [Hassan et al 2009].…”

Differential expression of two stress-inducible hsp70 genes by various stressors

“…Whereas HSC70 is constitutively expressed, HSP70 can be induced by various stresses such as hyperthermia, oxidative stress, heavy metals and amino acid analogues (Morimoto et al, 1992;Abe et al, 1998;Fukamachi et al, 1998;Wagner et al, 1999). HSP70 has an important function as a molecular chaperone for the folding, transport and assembly of newly synthesized polypeptides (Hartl, 1996).…”

Isolation of antibacterial response genes from the dung beetle Copris tripartitus (Coleoptera: Scarabaeidae) immunized with Escherichia coli

“…Among the total of 1,862 EST clones, 13 cDNA transcripts were expressed differentially in E. coli immunized larvae. logues, inhibitors of energy for energy metabolism, UV and irradiation, viral and bacterial infections, parasitism, alcohol, crowding, and inflammation (Lindquist & Craig, 1988;Hartl, 1996;Morimoto et al, 1990Morimoto et al, , 1992Abe et al, 1995;Fukamachi et al, 1998;Wagner et al, 1999;Sierra-River et al, 1993;Hatayama et al, 1993;Goodman & Blank, 1998;Gething & Sambrook, 1992;Sørensen & Loeschcke, 2001). Peptidoglycan recognition proteins are evolutionarily conserved molecules that are structurally related to bacterial amidases.…”