Zinc through the Three Domains of Life

Andreini, Claudia; Banci, Lucia; Bertini, Ivano; Rosato, Antonio

doi:10.1021/pr0603699

Cited by 571 publications

(498 citation statements)

References 33 publications

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“…The MIC results in NTYE/NT and NGSM are represented in Table 1 Zinc (Zn) is essential for proper functioning of large number of metalloproteins (Zn-binding proteins) and is required by organisms of all three domains of life (archaea, bacteria and eukaryote) thereby making it one of the key metal of life (Andreini et al 2006). However, metals in excess are detrimental and cause cellular damage (Bini 2010).…”

Section: Mic Of Zn and Zno Npsmentioning

confidence: 99%

Resistance of extremely halophilic archaea to zinc and zinc oxide nanoparticles

2015

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Industrialization as well as other anthropogenic activities have resulted in addition of high loads of metal and/or metal nanoparticles to the environment. In this study, the effect of one of the widely used heavy metal, zinc (Zn) and zinc oxide nanoparticles (ZnO NPs) on extremely halophilic archaea was evaluated. One representative member from four genera namely Halococcus, Haloferax, Halorubrum and Haloarcula of the family Halobacteriaceae was taken as the model organism. All the haloarchaeal genera investigated were resistant to both ZnCl 2 and ZnO NPs at varying concentrations. Halococcus strain BK6 and Haloferax strain BBK2 showed the highest resistance in complex/minimal medium of up to 2.0/1.0 mM ZnCl 2 and 2.0/1.0-0.5 mM ZnO NP. Accumulation of ZnCl 2 /ZnO NPs was seen as Haloferax strain BBK2 (287.2/549.6 mg g -1 ) [ Halococcus strain BK6 (165.9/388.5 mg g -1 ) [ Haloarcula strain BS2 (93.2/28.5 mg g -1 ) [ Halorubrum strain BS17 (29.9/16.2 mg g -1 ). Scanning electron microscopy and energy dispersive X-ray spectroscopy (SEM-EDX) analysis revealed that bulk ZnCl 2 was sorbed at a higher concentration (21.77 %) on the cell surface of Haloferax strain BBK2 as compared to the ZnO NPs (14.89 %).

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Section: Mic Of Zn and Zno Npsmentioning

confidence: 99%

Resistance of extremely halophilic archaea to zinc and zinc oxide nanoparticles

2015

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“…It has been estimated that about 10% of the proteins in biological systems need Zn for their structural and functional integrity (Andreini et al 2006). This element has also been indicated to be required as a cofactor in over 300 enzymes (Coleman 1998).…”

Section: Introductionmentioning

confidence: 99%

Effect of different foliar zinc application at different growth stages on seed zinc concentration and its impact on seedling vigor in rice

Boonchuay

Çakmak

Rerkasem

et al. 2013

Soil Science and Plant Nutrition

132

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This study evaluated how zinc (Zn) concentration of rice (Oryza sativa L.) seed may be increased and subsequent seedling growth improved by foliar Zn application. Eight foliar Zn treatments of 0.5% zinc sulfate (ZnSO 4 Á 7H 2 O) were applied to the rice plant at different growth stages. The resulting seeds were germinated to evaluate effects of seed Zn on seedling growth. Foliar Zn increased paddy Zn concentration only when applied after flowering, with larger increases when applications were repeated. The largest increases of up to ten-fold were in the husk, and smaller increases in brown rice Zn. In the first few days of germination, seedlings from seeds with 42 to 67 mg Zn kg À1 had longer roots and coleoptiles than those from seeds with 18 mg Zn kg À1 , but this effect disappeared later. The benefit of high seed Zn in seedling growth is also indicated by a positive correlation between Zn concentration in germinating seeds and the combined roots and shoot dry weight (r ¼ 0.55, p < 0.05). Zinc in rice grains can be effectively raised by foliar Zn application after flowering, with a potential benefit of this to rice eaters indicated by up to 55% increases of brown rice Zn, and agronomically in more rapid early growth and establishment.

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“…Almost one century ago, zinc and copper were recognized as trace elements with important roles in various metabolic processes in living organisms (Labbe and Thiele, 1999;Andreini et al, 2006). Zinc is the second most abundant transitional metal ion in human body, essential for the proper function of different enzymes and for a tight control of gene expression (Maverakis et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity

Milacic

Chen

Giovagnini

et al. 2008

Toxicology and Applied Pharmacology

144

128

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Zinc and copper are trace elements essential for proper folding, stabilization and catalytic activity of many metalloenzymes in living organisms. However, disturbed zinc and copper homeostasis is reported in many types of cancer. We have previously demonstrated that copper complexes induced proteasome inhibition and apoptosis in cultured human cancer cells. In the current study we hypothesized that zinc complexes could also inhibit the proteasomal chymotrypsin-like activity responsible for subsequent apoptosis induction. We first showed that zinc(II) chloride was able to inhibit the chymotrypsin-like activity of a purified 20S proteasome with an IC 50 value of 13.8 μM, which was less potent than copper(II) chloride (IC 50 5.3 μM). We then compared the potencies of a pyrrolidine dithiocarbamate (PyDT)-zinc(II) complex and a PyDT-copper(II) complex to inhibit cellular proteasomal activity, suppress proliferation and induce apoptosis in various human breast and prostate cancer cell lines. Consistently, zinc complex was less potent than copper complex in inhibiting the proteasome and inducing apoptosis. Additionally, zinc and copper complexes appear to use somewhat different mechanisms to kill tumor cells. Zinc complexes were able to activate calpain-, but not caspase-3-dependent pathway, while copper complexes were able to induce activation of both proteases. Furthermore, the potencies of these PyDT-metal complexes depend on the nature of metals and also on the ratio of PyDT to the metal ion within the complex, which probably affects their stability and availability for interacting with and inhibiting the proteasome in tumor cells.

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Zinc through the Three Domains of Life

Cited by 571 publications

References 33 publications

Resistance of extremely halophilic archaea to zinc and zinc oxide nanoparticles

Resistance of extremely halophilic archaea to zinc and zinc oxide nanoparticles

Effect of different foliar zinc application at different growth stages on seed zinc concentration and its impact on seedling vigor in rice

Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity

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