Zingerone Mitigates Carrageenan-Induced Inflammation Through Antioxidant and Anti-inflammatory Activities

Mehrzadi, Saeed; Khalili, Hamidreza; Fatemi, Iman; Malayeri, Alireza; Siahpoosh, Amir; Goudarzi, Mehdi

doi:10.1007/s10753-020-01320-y

Cited by 38 publications

(35 citation statements)

References 34 publications

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“…Intra plantar injection of 1% carrageenan induces local edema that increases with time releasing different inflammatory mediators in two phases. In the first phase that may last up to 1.5 h after injection of carrageenan involves the release of histamine, 5-hydroxytryptamine, platelet activating factor, bradykinin whereas in the second phase prostaglandin and various cytokines dominates ( Mehrzadi et al, 2020 ). All the compounds exhibited promising anti-inflammatory activity with paw edema inhibition ranging from 78.32% to 95.15% in 4th hour.…”

Section: Discussionmentioning

confidence: 99%

Synthesis, in vivo and in silico analgesic and anti-inflammatory studies of α-D-ribofuranose derivatives

Spriha

Rahman

2021

Saudi Pharmaceutical Journal

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Section: Discussionmentioning

confidence: 99%

Synthesis, in vivo and in silico analgesic and anti-inflammatory studies of α-D-ribofuranose derivatives

Spriha

Rahman

2021

Saudi Pharmaceutical Journal

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“…Doses of Carr, Ind, and CAPE were determined with reference to previous studies. 7,[14][15][16] The groups were designed as given below;…”

Section: Design Of the Studymentioning

confidence: 99%

“…5 In this way, the uncontrolled progression of inflammation and its occurrence at high levels causes inflammatory diseases, leading to dysfunctions in various organs. 3,6,7 In such cases, pharmacological intervention is required to reduce pain and increase life quality. 4,7 Steroidal anti-inflammatory drugs (SAIDs) and nonsteroidal anti-inflammatory drugs (NSAIDs) are currently used against inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan–induced paw edema in rats

et al. 2021

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In the present study, it is aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) against acute paw inflammation induced by carragenan (Carr) at macro and micro levels. Therefore, in this study, 1 hour after administering intraperitoneal of indomethacin (Ind) or CAPE (10 and 30 mg/kg body weight) to Sprague Dawley rats, Carr was injected intraplantarly into their right paws. The paw volumes of the rats were measured with a plethysmometer until the 4th hour. Also, X-ray and thermal camera images were taken to determine edema and temperature changes. At the end of the study, after the paw tissues and serums were taken, oxidative stress and inflammation status were determined using biochemical, molecular, and western blot techniques. In addition, lipid and protein profiles in paw tissue were determined using HPTLC and electrophoresis methods. The results depicted that a high dose of CAPE against Carr-induced inflammation may be almost as effective as Ind used as reference.

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“…PKC translocation leads to the activation of transcription factors NF‐κB, NF‐AT, and AP‐1 and to subsequent T‐cell activation. Furthermore, zingerone significantly reduced carrageenan‐induced rat paw edema, an effect associated to reduction of malonyl dialdehyde (MDA) (an index of oxidative stress), nitric oxide, COX‐2, PGE 2 , TNF‐α, and IL‐1β (Mehrzadi et al, 2020).…”

Section: Antiinflammatory and Analgesic Effectsmentioning

confidence: 99%

Ginger (Zingiber officinale Roscoe) as a nutraceutical: Focus on the metabolic, analgesic, and antiinflammatory effects

Pagano

Souto

Durazzo

et al. 2020

Phytotherapy Research

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Ginger (from the rizhome of Zingiber officinale Roscoe) has been widely used in ethnomedicine for the cure of several ailments. Main active ingredients include phenolic compounds named gingerols. In modern phytotherapy, ginger preparations are predominantly used to counteract nausea and vomiting in pregnant women. However, a number of other pharmacological actions of potential therapeutic interest, which might broaden the spectrum of its clinical use, have been reported. This focused review aims at giving a shot on the antinflammatory, analgesic, and metabolic actions of Zingiber officinale preparations, with a discussion on the clinical applications in knee osteoarthritis, dysmenorrhea, type-2 diabetes, hyperlipidemia, overweight, and obesity.

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Zingerone Mitigates Carrageenan-Induced Inflammation Through Antioxidant and Anti-inflammatory Activities

Cited by 38 publications

References 34 publications

Synthesis, in vivo and in silico analgesic and anti-inflammatory studies of α-D-ribofuranose derivatives

Synthesis, in vivo and in silico analgesic and anti-inflammatory studies of α-D-ribofuranose derivatives

Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan–induced paw edema in rats

Ginger (Zingiber officinale Roscoe) as a nutraceutical: Focus on the metabolic, analgesic, and antiinflammatory effects

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