Zingiber officinale extends Drosophila melanogaster life span in xenobiotic-induced oxidative stress conditions

Padalko, V. I.; Dzyuba, Viktoriya; Kozlova, Olena; Sheremet, Hanna; Protsenko, Olena

doi:10.1007/s11515-018-1493-3

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…The flies were fed food containing dithiothreitol, a reducing agent that induces oxidative stress, and Z. officinale powder and were inspected daily to examine the lifespan of flies. In addition to increasing the life expectancy of flies, Z. officinale significantly reduced the negative effects of dithiothreitol and oxidative stress outcomes [ 63 ]. We had also briefly investigated the immunomodulatory effects of Z. officinale extract using Drosophila DL1 cells stably expressing the Drosomycin -firefly luciferase reporter.…”

Section: Examples Of Studies To Test the Immunomodulatory Effect Of P...mentioning

confidence: 99%

Drosophila as an Animal Model for Testing Plant-Based Immunomodulators

Pratomo

Salim²,

Hori³

et al. 2022

IJMS

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Allopathic medicines play a key role in the prevention and treatment of diseases. However, long-term consumption of these medicines may cause serious undesirable effects that harm human health. Plant-based medicines have emerged as alternatives to allopathic medicines because of their rare side effects. They contain several compounds that have the potential to improve health and treat diseases in humans, including their function as immunomodulators to treat immune-related diseases. Thus, the discovery of potent and safe immunomodulators from plants is gaining considerable research interest. Recently, Drosophila has gained prominence as a model organism in evaluating the efficacy of plant and plant-derived substances. Drosophila melanogaster “fruit fly” is a well-known, high-throughput model organism that has been used to study different biological aspects of development and diseases for more than 110 years. Most developmental and cell signaling pathways and 75% of human disease-related genes are conserved between humans and Drosophila. Using Drosophila, one can easily examine the pharmacological effects of plants/plant-derived components by employing a variety of tests in flies, such as survival, anti-inflammatory, antioxidant, and cell death tests. This review focused on D. melanogaster’s potential for identifying immunomodulatory features associated with plants/plant-derived components.

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Section: Examples Of Studies To Test the Immunomodulatory Effect Of P...mentioning

confidence: 99%

Drosophila as an Animal Model for Testing Plant-Based Immunomodulators

Pratomo

Salim²,

Hori³

et al. 2022

IJMS

View full text Add to dashboard Cite

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Effects of Ginger (Zingiber officinale) on the Hallmarks of Aging

Matin,

Joshi,

Wang

et al. 2024

Biomolecules

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Ginger (Zingiber officinale Roscoe) is broadly used as a traditional remedy and food ingredient, and numerous preclinical and clinical studies have demonstrated health benefits in a range of age-related disorders. Moreover, longevity-promoting effects have been demonstrated in several (preclinical) research models. With this work, we aimed to comprehensively review the reported effects of ginger and its bioactive constituents on the twelve established hallmarks of aging, with the ultimate goal of gaining a deeper understanding of the potential for future interventions in the area of longevity-extension and counteracting of aging-related diseases. The reviewed literature supports the favorable effects of ginger and some of its constituents on all twelve hallmarks of aging, with a particularly high number of animal research studies indicating counteraction of nutrient-sensing dysregulations, mitochondrial dysfunction, chronic inflammation, and dysbiosis. On this background, validation in human clinical trials is still insufficient or is entirely missing, with the exception of some studies indicating positive effects on deregulated nutrient-sensing, chronic inflammation, and dysbiosis. Thus, the existing body of literature clearly supports the potential of ginger to be further studied in clinical trials as a supplement for the promotion of both lifespan and health span.

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Zingiber officinale extends Drosophila melanogaster life span in xenobiotic-induced oxidative stress conditions

Cited by 2 publications

References 21 publications

Drosophila as an Animal Model for Testing Plant-Based Immunomodulators

Drosophila as an Animal Model for Testing Plant-Based Immunomodulators

Effects of Ginger (Zingiber officinale) on the Hallmarks of Aging

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