Zn catalyzed a simple and convenient method for thiourea synthesis

Zinc Promoted Urea Synthesis Using Carbonyldiimidazole as Carbonyl Source and Its Application for the Synthesis of Cariprazine

“…Complex X transformed into Y by releasing imidazole (3) . In the last step, the second amine (4) reacts with complex Y and gives urea product Z [29] …”

“…In the last step, the second amine (4) reacts with complex Y and gives urea product Z. [29] Scheme 3. Synthesis of un-symmetrical urea derivatives.…”

“…As part of our ongoing research on Zn metal for organic synthesis, our group has developed various transformations, including N-alkylation of amine, [21] thiol ester synthesis, [22] acylation of ylides, [23] N-sulfonylation of amines, [24] syntheses of substituted benzoxazole, [25] Friedel-crafts acylation, [26] amide formation, [27] synthesis of carbamate, [27,28] synthesis of thiourea, [29] and S-alkylation. [30] Recently our group has reported a protocol for unsymmetrical urea synthesis by using carbamoyl chloride.…”

Novel 9H‐flouren containing indoline scaffolds: Synthesis, characterization, antimicrobial assays, and molecular docking study

“…The (R)-3-(5-(2-aminopropyl)-7-cyanoindolin-1-yl)propyl benzoate (indoline amine) (10) was prepared by following literature methods [10][11][12][13] in overall ten steps. The N-alkylation reaction of indoline (1) was done in presence of 1-bromo-3-chloropropane, zinc and acetic acid in tetrahydrofuran (THF) at 60 C to afford intermediate 1-(3-chloropropyl)indoline [14] (2). The obtained intermediate 2 was reacted with benzoic acid in the presence of organic base triethyl amine (Et 3 N) in DMF at 100 C for 12 h to get crude compound 3-(indolin-1-yl) propyl benzoate [15] (3), which was recrystallized with conc.…”