ZnO/Nanocarbons‐Modified Fibrous Scaffolds for Stem Cell‐Based Osteogenic Differentiation

Xia, Yi; Fan, Xin; Yang, Hua; Li, Ling; He, Chao; Cheng, Chong; Haag, Rainer

doi:10.1002/smll.202003010

Cited by 59 publications

(45 citation statements)

References 60 publications

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“…As a proof-of-concept study this scaffold was shown to be non-toxic to rat BMSC and improved osteogenic differentiation capacity of cultured BMSC, while significantly reducing bacterial populations [ 86 ]. Using a similar concept, ZnO/nanocarbon modified fibrous scaffolds have demonstrated osteogenic and antibacterial properties, albeit in vitro [ 87 ]. While there are still limitations with regard to the functional capacity of hydrogels and scaffolds, the unique and versatile configurations and continuous refinement in combination with BMSC treatment holds considerable promise for bone regeneration [ 70 , 74 ].…”

Section: Skeletal Tissue Regeneration—advancements Over the Last Dmentioning

confidence: 99%

Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue

Arthur

Gronthos

2020

IJMS

173

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There has been an escalation in reports over the last decade examining the efficacy of bone marrow derived mesenchymal stem/stromal cells (BMSC) in bone tissue engineering and regenerative medicine-based applications. The multipotent differentiation potential, myelosupportive capacity, anti-inflammatory and immune-modulatory properties of BMSC underpins their versatile nature as therapeutic agents. This review addresses the current limitations and challenges of exogenous autologous and allogeneic BMSC based regenerative skeletal therapies in combination with bioactive molecules, cellular derivatives, genetic manipulation, biocompatible hydrogels, solid and composite scaffolds. The review highlights the current approaches and recent developments in utilizing endogenous BMSC activation or exogenous BMSC for the repair of long bone and vertebrae fractures due to osteoporosis or trauma. Current advances employing BMSC based therapies for bone regeneration of craniofacial defects is also discussed. Moreover, this review discusses the latest developments utilizing BMSC therapies in the preclinical and clinical settings, including the treatment of bone related diseases such as Osteogenesis Imperfecta.

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Section: Skeletal Tissue Regeneration—advancements Over the Last Dmentioning

confidence: 99%

Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue

Arthur

Gronthos

2020

IJMS

173

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“…Therefore, these types of materials can be deformed with physiological movements and consequently, provide an electrical stimulation to the tissue microenvironment, enhancing the tissue regeneration without any external source [ 39 ]. Several piezoelectric ceramics including potassium sodium niobate [ 40 ], lithium sodium potassium niobate [ 41 ], zinc oxide [ 42 ], or polymers such as polyvinylidene fluoride and PLA, are being studied to determine which material offers the best properties in terms of developing efficient electroactive prosthetic implants for bone repair [ 43 , 44 ].…”

Section: Strategies Promoting Bone Healing Through An Endogenous Responsementioning

confidence: 99%

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Macías

Alcorta-Sevillano

Infante

et al. 2021

IJMS

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Bone damage leading to bone loss can arise from a wide range of causes, including those intrinsic to individuals such as infections or diseases with metabolic (diabetes), genetic (osteogenesis imperfecta), and/or age-related (osteoporosis) etiology, or extrinsic ones coming from external insults such as trauma or surgery. Although bone tissue has an intrinsic capacity of self-repair, large bone defects often require anabolic treatments targeting bone formation process and/or bone grafts, aiming to restore bone loss. The current bone surrogates used for clinical purposes are autologous, allogeneic, or xenogeneic bone grafts, which although effective imply a number of limitations: the need to remove bone from another location in the case of autologous transplants and the possibility of an immune rejection when using allogeneic or xenogeneic grafts. To overcome these limitations, cutting edge therapies for skeletal regeneration of bone defects are currently under extensive research with promising results; such as those boosting endogenous bone regeneration, by the stimulation of host cells, or the ones driven exogenously with scaffolds, biomolecules, and mesenchymal stem cells as key players of bone healing process.

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“…Zinc (Zn), one of the most important trace elements in bone tissues [ 7 ], has been widely reported to have a stimulatory effect on the osteogenic differentiation of stem cells [ 8 – 10 ]. β-Tricalcium phosphate (β-TCP), a kind of bioceramic, has been commonly used as a suitable carrier to deliver ions/biomolecules/drugs [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli

Huang

Zhu

et al. 2021

J Nanobiotechnol

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Metal ions have been identified as important bone metabolism regulators and widely used in the field of bone tissue engineering, however their exact role during bone regeneration remains unclear. Herein, the aim of study was to comprehensively explore the interactions between osteoinductive and osteo-immunomodulatory properties of these metal ions. In particular, the osteoinductive role of zinc ions (Zn2+), as well as its interactions with local immune microenvironment during bone healing process, was investigated in this study using a sustained Zn2+ delivery system incorporating Zn2+ into β-tricalcium phosphate/poly(L-lactic acid) (TCP/PLLA) scaffolds. The presence of Zn2+ largely enhanced osteogenic differentiation of periosteum-derived progenitor cells (PDPCs), which was coincident with increased transition from M1 to M2 macrophages (M$$\varphi $$ φ s). We further confirmed that induction of M2 polarization by Zn2+ was realized via PI3K/Akt/mTOR pathway, whereas marker molecules on this pathway were strictly regulated by the addition of Zn2+. Synergically, this favorable immunomodulatory effect of Zn2+ further improved the osteogenic differentiation of PDPCs induced by Zn2+ in vitro. Consistently, the spontaneous osteogenesis and pro-healing osteoimmunomodulation of the scaffolds were thoroughly identified in vivo using a rat air pouch model and a calvarial critical-size defect model. Taken together, Zn2+-releasing bioactive ceramics could be ideal scaffolds in bone tissue engineering due to their reciprocal interactions between osteoinductive and immunomodulatory characteristics. Clarification of this synergic role of Zn2+ during osteogenesis could pave the way to develop more sophisticated metal-ion based orthopedic therapeutic strategies.

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ZnO/Nanocarbons‐Modified Fibrous Scaffolds for Stem Cell‐Based Osteogenic Differentiation

Cited by 59 publications

References 60 publications

Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue

Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli

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