Zur Auswertung der Digitalisblätter im Froschversuch

The Up-and-Down Method with Small Samples

“…However, as an example we may take Behren's data [1] on digitalis in frogs. However, as an example we may take Behren's data [1] on digitalis in frogs.…”

A Pharmacological Study of a Homologous Series of Sodium Alkyl Sulfates†

“…The LDso determinations were carried out according to the method of Dragstedt and Lang (10). elaborated upon by Behrens (11). The numerical results are presented in Table 11.…”

A simple statistical method for the calculation of mortality percentages in digitalis assays**Presented at the Group Meeting on Statistical Methods as Applied to Biological Assays of the Committee of Revision of the United States Pharmacopoeia, Washington, D. C., May 13, 1940. A part of the funds used in this research was supplied by a grant from the Medical Research Fund of the University of Minnesota.

“…Dragstedt and Lang clearly enunciated these assumptions and applied them in the above manner t o the calculation of percentage mortality statistics of the effects of various respiratory stimulants in acute cocaine poisoning in rabbits. Behrens (7) in 1929, apparently unaware of Dragstedt's publication, stated and applied the same fundamental assumptions to the calculation of a percentage mortality curve for the intravenous infusion of a strophanthin solution to frogs. He found that when his experimental determinations of the individual intravenous fatal dose on 140 frogs were analyzed as grouped data on the basis of the above assumptions, the percentage mortality curve agreed quite closely with the sigmoid dose-mortality curve previously determined experimentally on the same species of frogs (Rana temporaria) by Trevan.…”