Zur Morphologie und Pathophysiologie der Nebennierenrinde von Feten und Neugeborenen

Kloos, K; Staemmler, H. J.

doi:10.1007/bf00954508

Cited by 24 publications

(2 citation statements)

References 18 publications

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“…injections. An intrauterine change to high permanent zone activity is also suggested by the high C-21 steroid content of the fetal adrenals in cases of postmaturi1.y (Kloos and Staemmler, 1953) and from the olxervation of Klein et al (1971) of a case of intrauterine fetal death at 32 weeks with very high excretion of C-21 corticosteroid sulphatc: esters. Turnbull and Anderson (1969) and Liggins (1973) suggested that prolonged gestation in anencephaly might be due to diminished fetal hypophysial-adrenal activity as in sheep.…”

Section: Discussionmentioning

confidence: 94%

“…It may be that the presence of the placenta determines the predominance of the fetal zone and that a shift to predominance of the permanent zone takes place after delivery and even before delivery in cases of severe placental insufficiency. Indications for a "prenatal" shift are fetal zone degeneration, activation of the permanent zone and a "stress" thymus (Kloos and Staemmler, 1953;Dhom et al, 1958;Becker-Bloemkolk, 1973). Intrauterine fetal growth retardation and postmaturity lead to a fall in maternal oestriol excretion (Beischer and Brown, 1972;Sybulski and Maughan, 1972;Podoba et al, 1973).…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Hypophysial Hormones and Human Chorionic Gonadotrophin (Hcg) on the Anencephalic Fetal Adrenal Cortex and on Parturition in the Human

Honnebier

Jöbsis

Swaab

1974

BJOG

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Summary The present study examined whether the adrenal of the anencephalic fetus could be stimulated in utero with adrenocorticotrophic hormone (ACTH) or human chorionic gonadotrophin (HCG) injected directly into the fetus. The effect of the injections was judged by measuring hormone levels and by histological and histochemical examination of the fetal adrenals. The effect was also studied of stimulation of the fetal adrenal or the injection of neurohypophysial hormones on the initiation of parturition. HCG appeared to have no effect on the fetal adrenal while large doses of ACTH apparently stimulated adrenal growth and function to some extent. The possible presence of other adrenotropic factors is discussed as is the role of the placenta in determining the type of fetal adrenal activity as judged by predominance of the permanent or fetal zone of the fetal adrenal. Although labour was induced in one patient by means of injecting the fetus with oxytocin, we do not believe that the fetal hypothalamus provides the primary stimulus for the onset of labour in humans.

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Section: Discussionmentioning

confidence: 94%