Zur Synthese derm-Aminophenylboronsäure, Effektor in der Affinitätschromatografie von Nukleinsäuren

Covalent Interactions in Chemosensor Design

“…As a matter of fact, there are several examples of boronic acid binding to diols/hydroxyl groups on six-membered rings [5,58,91,92]. Furthermore, immobilized boronic acids have been used to isolate glycans and glycoproteins [93][94][95][96][97][98][99][100][101][102]; free boronic acids have been used for carbohydrate derivatization for mass spectrometric analysis [93,[103][104][105] with much success; SBLs have been used to recognize cell-surface carbohydrate biomarkers which only contain diols on six-membered rings or linear structures [5], and boronic-acid-modified DNA aptamers have been selected to recognize glycoproteins with the ability to differentiate glycosylation variation [57,106]. Such reports lend validity to the use of boronic acids for binding with biologically important carbohydrates that only have hydroxyl groups on six-membered rings.…”