α-Glucosidase Inhibitors from Clove (Syzgium aromaticum)

Structure-activity Relationships for α-Glucosidase Inhibition of Baicalein, 5,6,7-Trihydroxyflavone: the Effect of A-Ring Substitution

“…The -glucosidase inhibitory activity was measured as described previously. 4,5) The crude rat intestinal -glucosidase solution prepared from rat intestinal acetone powder contained 526 mg of protein, and its relative -glucosidase activity against sucrose was 0.385 unit/mg protein or 0.352 unit/ml enzyme solution. The reaction mixture consisted of crude enzyme solution (0.2 ml), 56 mM sucrose in 0.1 M potassium phosphate buffer (pH 6.3, 0.2 ml), and the test sample in 50% aqueous dimethyl sulfoxide (DMSO, 0.1 ml).…”

α-Glucosidase Inhibitory Activity of a 70% Methanol Extract from Ezoishige (Pelvetia babingtoniide Toni) and Its Effect on the Elevation of Blood Glucose Level in Rats

“…In previous in vitro studies, a-glucosidase inhibitors have been isolated from various food materials, e.g., ougon, 3) hijiki, 4) tochu-cha, 5) welsh onion, 6) and clove. 7) However, the in vitro inhibitory activity is not always related to the in vivo activity for physiological action.…”

Methyl Caffeate as an α-Glucosidase Inhibitor fromSolanum torvumFruits and the Activity of Related Compounds

“…It is caused by continual hyperglycemia and develops along with increases in obesity and aging in the general population. 1) One of the therapeutic approaches to decreasing postprandial hyperglycemia is to retard absorption of glucose by inhibition of carbohydrate hydrolyzing enzymes -amylase and -glucosidase in the digestive organs.2) In recent years, many efforts have been made to search for effective -glucosidase inhibitors from natural sources in order to develop a physiological functional food or to discover lead compounds for medicinal usage against diabetes.3) In the course of our search for rat intestinal -glucosidaseinhibiting principles from various plants, we have isolated and identified several active compounds from plants grown in Asian regions, including Japan, [4][5][6][7] Thailand, 8,9) China, 10,11) and Nepal. 12) In this paper, we present the results of a screening of plants cultivated in Tanegashima, a southern island of Japan, for rat intestinal -glucosidase inhibition.…”

“…3) In the course of our search for rat intestinal -glucosidaseinhibiting principles from various plants, we have isolated and identified several active compounds from plants grown in Asian regions, including Japan, [4][5][6][7] Thailand, 8,9) China, 10,11) and Nepal. 12) In this paper, we present the results of a screening of plants cultivated in Tanegashima, a southern island of Japan, for rat intestinal -glucosidase inhibition.…”

“…2) In recent years, many efforts have been made to search for effective -glucosidase inhibitors from natural sources in order to develop a physiological functional food or to discover lead compounds for medicinal usage against diabetes. 3) In the course of our search for rat intestinal -glucosidaseinhibiting principles from various plants, we have isolated and identified several active compounds from plants grown in Asian regions, including Japan, [4][5][6][7] Thailand, 8,9) China, 10,11) and Nepal. 12) In this paper, we present the results of a screening of plants cultivated in Tanegashima, a southern island of Japan, for rat intestinal -glucosidase inhibition.…”