α-Glucosidase inhibitory activity of selected Philippine plants

Lawag, Ivan Lozada; Aguinaldo, Alicia M.; Naheed, Suad; Mosihuzzaman, M.

doi:10.1016/j.jep.2012.08.019

Cited by 67 publications

(43 citation statements)

References 18 publications

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“…In addition, some flavonoids and polyphenols as well as sugar derivatives (acarbose) are found to be effective in inhibiting α-glucosidase [4,[8][9][10][11][12]. Therefore, discovery of α-glucosidase inhibitors from traditional plants is very helpful in the development of new antidiabetic drugs.…”

Section: Introductionmentioning

confidence: 99%

ÃÂ±-Glucosidase Inhibitory Activity of Common Traditional Medicinal Plants Used for Diabetes Mellitus

Hamza¹,

Ksiksi²,

Shamsi³

et al. 2015

J Develop Drugs

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Inhibition of α-glucosiase and the associated reduction of glucose absorption is an attractive approach for decreasing postprandial hyperglycemia and for the discovery of potent antidiabetic agents. One of the most important sources of potential α-glucosiase inhibitors represents the class of polyphenols. This paper aims to evaluate previous herbal polyphenol-rich extracts plan on the management of diabetes mellitus, to address their α-glucosidase inhibitory activity. Polyphenol-rich extracts from thirteen widely used traditionally anti-diabetic plants in Asia and Mediterranean regions were evaluated for their potential α-glucosidase inhibitory activity. Among these evaluated plants, 10 were much stronger than that of acarbose standard. Punica granatum manifested the highest inhibitory activity with IC 50 at 3.59 ± 0.11 µg/mL, followed by Psidium guajava with IC 50 at 8.08 ± 0.10 µg/mL and Cinnamomum zeylanicum with IC 50 at 9.87.08 ± 0.14 µg/mLA. A high correlation (r=0.65, p<0.001) was observed between α-glucosidase inhibition and total phenolic content of all plants. Punica granatum, P. guajava, C. zeylanicum and Ziziphus spina-christi had also the highest total phenolic content. Extracts for the above studied plant species may potentially replace acarbose in its current clinical use in improving post-prandial glycaemic control in type 2 diabetics. As a result, these polyphenol-rich extracts potentially offer a complementary approach to develop functional food and potential antidiabetic agents.

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Section: Introductionmentioning

confidence: 99%

ÃÂ±-Glucosidase Inhibitory Activity of Common Traditional Medicinal Plants Used for Diabetes Mellitus

Hamza¹,

Ksiksi²,

Shamsi³

et al. 2015

J Develop Drugs

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“…It also increased the glucose uptake with phosphorylation of insulin receptor substrate 1 (Davis et al, ). Water extract of Averrhoa bilimbi decreased the activity of hepatic glucose 6‐phosphatase (Ali, Houghton, & Soumyanath, ) and also inhibited the alpha‐glucosidase and alpha‐amylase (Lawag, Aguinaldo, Naheed, & Mosihuzzaman, ). Its diethyl ether extract showed 93% inhibition of protein tyrosine phosphatase (Teng et al, ).…”

Section: Methodsmentioning

confidence: 99%

Enzymes inhibitors from natural sources with antidiabetic activity: A review

Alam

Shafique

Amjad

et al. 2018

Phytotherapy Research

130

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Natural products have been extensively investigated for antidiabetic therapy. Many of the natural products have direct or indirect effect in diabetes pathways as enzyme inhibitors. The most involved mechanisms are inhibition of intestinal alphaglucosidase and alpha-amylase, lens aldose reductase, oxidative stress protection, inhibition of formation of advanced glycation end products, inhibition of aldose reductase, lowering plasma glucose levels, altering enzyme activity of hexokinases and glucose-6-phosphate, synthesizing and releasing of insulin, postprandial hyperglycemia inhibition, stimulation of GLUT-4, decreasing activity of G6P, lowering the level of skeletal hexokinases, etc. The following medicinal plants products or extracts showed promising effects as enzyme inhibitors:officinale. Some of the group of phytochemicals isolated with enzyme inhibition activities are Alkaloids, sesquiterpene and saponins, polysaccharides, flavonoids, dietary fibers, ferulic acid, tannins, limonene, and oleuropeoside. This review will provide very useful material to enhance the efficiency of rational antidiabetic drug design.

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“…From that experiment this plant was screened for their potential α-glucosidase inhibitory activity and the result was positive. 17 They carried out an experiment on methanolic extract of Antidesma bunius stem, barks and leaves to evaluate α-glucosidase inhibitory activity. Methanolic extraction of leaves showed the highest α-glucosidase inhibitory activity.…”

Section: Hypoglycemic Activitymentioning

confidence: 99%

A review on phytochemical and pharmacological potentials of Antidesma bunius

Islam¹,

Ahammed²,

Sukorno³

et al. 2018

JAPLR

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Antidesma bunius (Family-Euphorbiaceae), also popularly known in the Philippines as bignay and is a found in several Asian countries. This plant is famous in South Asia. In the traditional medicine, various plant parts such as root, bark, leaves, fruits which are used in traditional system of medicine for a long time, for the treatment of various disease due to having cytotoxic, anti-diabetic, antioxidant, antiradical, thrombolytic activity, antiplatelet, anticoagulant, anti-dysenteric, antimicrobial, antihypertensive, anticancer and sudorific activity. This plant can also be used as pesticide agents. This plant also has a role in improvement of blood circulation. It is a good remedy for snakebite, coughs, flatulence and intestinal colic. Phytochemical analysis of the Antidesma bunius has confirmed presence of different kinds of flavonoids, terpene, sugar, saponin, tannin, toxic alkaloids, phenolic acids, procyanidin B1, procyanidin B2 and anthocyanins. This present study gives an insight to the pharmacogonstical, phytochemical and pharmacological properties of Antidesma bunius.

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α-Glucosidase inhibitory activity of selected Philippine plants

Cited by 67 publications

References 18 publications

ÃÂ±-Glucosidase Inhibitory Activity of Common Traditional Medicinal Plants Used for Diabetes Mellitus

ÃÂ±-Glucosidase Inhibitory Activity of Common Traditional Medicinal Plants Used for Diabetes Mellitus

Enzymes inhibitors from natural sources with antidiabetic activity: A review

A review on phytochemical and pharmacological potentials of Antidesma bunius

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α-Glucosidase inhibitory activity of selected Philippine plants

Cited by 67 publications

References 18 publications

ÃÂ±-Glucosidase Inhibitory Activity of Common Traditional Medicinal Plants Used for Diabetes Mellitus

ÃÂ±-Glucosidase Inhibitory Activity of Common Traditional Medicinal Plants Used for Diabetes Mellitus

Enzymes inhibitors from natural sources with antidiabetic activity: A review

A review on phytochemical and pharmacological potentials of Antidesma bunius

Contact Info

Product

Resources

About

ÃÂ±-Glucosidase Inhibitory Activity of Common Traditional Medicinal Plants Used for Diabetes Mellitus

ÃÂ±-Glucosidase Inhibitory Activity of Common Traditional Medicinal Plants Used for Diabetes Mellitus