α-synuclein as a promising biomarker for developing diagnostic tools against neurodegenerative synucleionopathy disorders

A binding-triggered hybridization chain reaction cascade multi-site activated CRISPR/Cas12a signal amplification strategy for sensitive detection of α-synuclein

“…3 Now, α-syn is considered as a promising biomarker for the early diagnosis and disease progression monitoring of PD. [10][11][12][13][14][15] Therefore, effective detection of α-syn is important for revealing its role in pathogenesis, further verifying its function in clinical diagnosis, and developing drugs for delaying disease progression.…”