α1-Antitrypsin alleviates inflammation and oxidative stress by suppressing autophagy in asthma

Huang, Changyu; Hu, Ruicheng; Li, Jie; Chen, Binbin; Dai, Aiguo

doi:10.1016/j.cyto.2021.155454

Cited by 7 publications

(7 citation statements)

References 38 publications

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“…For example, α1-antitrypsin represses autophagy to ameliorate inflammation and oxidative stress in asthma. 26 Furthermore, adiponectin regulates adenosine monophosphate-activated protein kinase (AMPK) pathway in obesity-related asthma mice to reduce airway inflammation and oxidative stress. 27 In asthma, fucoxanthin alleviates oxidative stress and inflammation.…”

Section: Csr Treatment Reduced Lung Damage In Ovastimulated Micementioning

confidence: 99%

Chryseriol attenuates the progression of OVA-induced asthma in mice through NF-κκB/HIF-1αα and MAPK/STAT1 pathways

Deng

Xie

et al. 2023

Allergol Immunopathol

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Background: Asthma is a hackneyed chronic inflammatory disease of the airway. Chryseriol (CSR) is a kind of flavonoid, and has the effect of bronchiectasis, indicating its potential application for treating respiratory diseases. However, the functions of CSR in asthma have not been reported till now. Materials and methods: The histopathologic changes of the lung tissues were assessed by hematoxylin and eosin staining. The cell apoptosis was identified through terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay. Total numbers of eosinophils, neutrophils, and macrophages were assessed under microscope. The levels of interleukin (IL)-1β, IL-4, IL-5, and IL-13 were detected by enzyme-linked-immunosorbent serologic assay. The airway hyper-responsiveness (AHR) was evaluated by the whole body plethysmography. The levels of methane dicarboxylic aldehyde, superoxide dismutase, glutathione S-transferase, and glutathione in lung homogenates were confirmed by using corresponding commercial kits. The protein expressions were examined by Western blot analysis. Results: The ovalbumin (OVA) was utilized to establish asthma mouse model. At first, it was revealed that CSR treatment reduced lung injury in OVA-stimulated mice. Moreover, cell apoptosis was enhanced after OVA stimulation but was attenuated by CSR treatment. In addition, CSR treatment decreased the infiltration of inflammatory cells and the production of inflammatory factors in OVA-treated mice. Further investigations demonstrated that CSR treatment relieved AHR in OVA-stimulated mice. The oxidative stress was strengthened in OVA-treated mice, but these effects were relieved by CSR treatment. Lastly, it was discovered that CSR treatment retarded nuclear factor kappa B (NF-κB)/hypoxia-inducible factor 1 alpha (HIF-1α) and p38 mitogen-activated protein kinase (MAPK)/signal transducer and activator of transcription 1 (STAT1) pathways in OVA-triggered asthma mice. Conclusion: Our findings proved that CSR attenuated the progression of OVA-induced asthma in mice through inhibiting NF-κB/HIF-1α and MAPK/STAT1 pathways. This work might highlight the functions of CSR in the treatment of asthma.

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Section: Csr Treatment Reduced Lung Damage In Ovastimulated Micementioning

confidence: 99%

Chryseriol attenuates the progression of OVA-induced asthma in mice through NF-κκB/HIF-1αα and MAPK/STAT1 pathways

Deng

Xie

et al. 2023

Allergol Immunopathol

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“…In addition, the administration of yeast fermentate prebiotic suppresses perivascular infiltrations of eosinophils and ameliorates oxidative damage to the lung of asthmatic mice, associated with enhanced expression of ATG5, Beclin1, and LC3-II [ 37 ]. Similarly, α 1-antitrypsin exerts antiasthmatic effects by alleviating airway allergic inflammation and oxidative stress through suppressing autophagy and thus ameliorating asthma [ 38 ]. In support, increased levels of IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid, infiltration of inflammatory cells in lung tissues, and airway hyperresponsiveness are observed along with autophagy activation in ovalbumin-induced mice; also, these effects are inhibited by luteolin, which blocks autophagy by activating the PI3K/AKT/mTOR pathway and suppressing the Beclin1-PI3KC3 protein complex [ 39 ].…”

Section: Autophagy and Asthmamentioning

confidence: 99%

The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy

Wang

Yuan

et al. 2023

Mediators of Inflammation

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Asthma is a chronic respiratory disease frequently associated with airway inflammation and remodeling. The development of asthma involves various inflammatory phenotypes that impact therapeutic effects, and macrophages are master innate immune cells in the airway that exert diverse functions including phagocytosis, antigen presentation, and pathogen clearance, playing an important role in the pathogeneses of asthma. Recent studies have indicated that autophagy of macrophages affects polarization of phenotype and regulation of inflammation, which implies that regulating autophagy of macrophages may be a potential strategy for the treatment of asthma. Thus, this review summarizes the signaling pathways and effects of macrophage autophagy in asthma, which will provide a tactic for the development of novel targets for the treatment of this disease.

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“…In addition, a novel biologic anti-IL-5 antibody significantly reduced LC3 II expression in lung homogenates ( 19 ). High-dose luteolin, yeast-fermented prebiotic, ketamine and α1-antitrypsin inhibit autophagy in lung tissue ameliorating asthmatic mice ( 42 , 134 , 136 , 144 ). Chinese herbal medicines can also regulate autophagy and can be potentially used for asthma treatment.…”

Section: Autophagy and Asthma Treatmentmentioning

confidence: 99%

New insights into autophagy in inflammatory subtypes of asthma

Dong

Yang

et al. 2023

Front. Immunol.

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Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis. Dysregulation of autophagy is involved in the pathogenesis of many diseases. In the context of asthma, autophagy has been shown to be associated with inflammation, airway remodeling, and responsiveness to drug therapy. In-depth characterization of the role of autophagy in asthma can enhance the understanding of the pathogenesis, and provide a theoretical basis for the development of new biomarkers and targeted therapy for asthma. In this article, we focus on the relationship of autophagy and asthma, and discuss its implications for asthma pathogenesis and treatment.

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α1-Antitrypsin alleviates inflammation and oxidative stress by suppressing autophagy in asthma

Cited by 7 publications

References 38 publications

Chryseriol attenuates the progression of OVA-induced asthma in mice through NF-κκB/HIF-1αα and MAPK/STAT1 pathways

Chryseriol attenuates the progression of OVA-induced asthma in mice through NF-κκB/HIF-1αα and MAPK/STAT1 pathways

The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy

New insights into autophagy in inflammatory subtypes of asthma

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