β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid

Bejaoui, Meriem; Villareal, Myra O.; Isoda, Hiroko

doi:10.18632/aging.102048

Cited by 43 publications

(48 citation statements)

References 69 publications

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“…The WNT/β-catenin pathway has a critical role in regulating the hair cycle by promoting hair growth ( 35 ). β-Catenin is a key regulator of hair follicle growth, and it is reported to be the primary initiator of the anagen phase ( 36 ). SFRP2 has been reported to be involved in several cellular activities and biological processes via the down-regulation of β-catenin in nuclear translocation.…”

Section: Resultsmentioning

confidence: 99%

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

et al. 2020

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The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment. Because of the importance of paracrine signaling in this process, secretome and exosomes were isolated from DP cell culture, and their therapeutic efficacies were investigated. We demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. Western blot and immunofluorescence imaging were used to demonstrate that DP spheroid–derived exosomes up-regulated β-catenin, promoting the development of hair follicles.

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Section: Resultsmentioning

confidence: 99%

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

et al. 2020

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“…We identified procyanidin B2 in C. inophyllum extracts, which gives rise to other potential targets to consider for further study of the hair growth activity of the extracts. Sinapic acid [ 65 ] and 3,4,5-tri- O -caffeoylquinic acid [ 66 ] both promote hair growth via several factors, namely stimulation of β-catenin production. Coumaric and sinapic acids are both hydroxycinnamic acids, and coumaric acid was identified in all three ethyl acetate extracts of F. berteroana, C. inophyllum and B. pilosa ( Table 1 ), further pointing towards a potential Wnt/β-catenin target stimulation of hair growth of our extracts and fractions.…”

Section: Discussionmentioning

confidence: 99%

Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells

Hughes

Greff

et al. 2020

Molecules

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Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts significantly increased proliferation of dermal papilla cells. Furthermore, LC-MS/MS analysis revealed a diversity of molecules, flavonoids, iridoids and organic acids, some known for hair-inducing properties. Finally, specific extracts and fractions of all three plants either upregulated CCND1, LEF1 and PPARD involved in stimulating hair follicle proliferation and/or lowered the gene expression levels of hair growth inhibiting factors, DKK1 and TGFB1. Our findings suggest that extracts from B. pilosa, C. inophyllum and F. berteroana are interesting candidates to stimulate hair growth.

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“…Moreover, in our previous studies, we demonstrated that TCQA promoted hair regrowth and pigmentation in eight-weeks-old C3H male, human dermal papilla cells and human melanocytes via the upregulation of Wnt/β-catenin pathway and its target genes. TCQA upregulated pathways involved in skin and hair stem cell differentiation and the protein expression of CD34, known to be enhanced when melanocytes stem cells are differentiating [ 31 – 33 ]. On the other hand, TCQA triggered the differentiation of Human Neural Stem Cells (hNSC) via Bone Morphogenetic Protein (BMP) pathway and the induction of cell cycle arrest [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Regulating cell fate of human amnion epithelial cells using natural compounds: an example of enhanced neural and pigment differentiation by 3,4,5-tri-O-caffeoylquinic acid

et al. 2021

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Over the past years, Human Amnion Epithelial Cells (hAECs), a placental stem cell, are gaining higher attention from the scientific community as they showed several advantages over other types of stem cells, including availability, easy accessibility, reduced rejection rate, non-tumorigenicity, and minimal legal constraint. Recently, natural compounds are used to stimulate stem cell differentiation and proliferation and to enhance their disease-treating potential. A polyphenolic compound 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA) has been previously reported to induce human neural stem cell differentiation and may affect melanocyte stem cell differentiation as well. In this study, TCQA was tested on 3D cultured hAECs after seven days of treatment, and then, microarray gene expression profiling was conducted of TCQA-treated and untreated control cells on day 0 and day 7. Analyses revealed that TCQA treatment significantly enriched pigment and neural cells sets; besides, genes linked with neurogenesis, oxidation–reduction process, epidermal development, and metabolism were positively regulated. Interestingly, TCQA stimulated cell cycle arrest-related pathways and differentiation signaling. On the other hand, TCQA decreased interleukins and cytokines expression and this due to its anti-inflammatory properties as a polyphenolic compound. Results were validated to highlight the main activities of TCQA on hAECs, including differentiation, cell cycle arrest, and anti-inflammatory. This study highlights the important role of hAECs in regenerative medicine and the use of natural compounds to regulate their fate.

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β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid

Cited by 43 publications

References 69 publications

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells

Regulating cell fate of human amnion epithelial cells using natural compounds: an example of enhanced neural and pigment differentiation by 3,4,5-tri-O-caffeoylquinic acid

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