γ-amino butyric acid-enriched barley bran lowers adrenocorticotropic hormone and corticosterone levels in immobilized stressed rats

Abinaya, Ravichandran Vijaya; Pichiah, Pichiah Balasubramanian Tirupathi; Thomas, Shalom Sara; Kim, Su-Gon; Han, Doo-Won; Song, Yoonseok; Oh, Suk‐Heung; Cha, Youn‐Soo

doi:10.1111/jfbc.12324

Cited by 8 publications

(4 citation statements)

References 49 publications

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“…Interestingly, the in ovo feeding of GABA could reduce the plasma corticosterone levels of the birds exposed to HS. Earlier studies have revealed that dietary and GABAenriched barley bran could lower adrenocorticotropic hormone (ACTH) and corticosterone levels in pigs and rats [46,47]. Indeed, under stressful conditions, the hypothalamus releases the corticotropin-releasing hormone, which stimulates the secretion of ACTH from the anterior pituitary gland [48].…”

Section: Discussionmentioning

confidence: 99%

Effects of In Ovo Feeding of γ-Aminobutyric Acid on Growth Performances, Plasma Metabolites, and Antioxidant Status in Broilers Exposed to Cyclic Heat Stress

et al. 2021

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γ-aminobutyric acid (GABA) is an amino acid used for mitigating the detrimental effects of heat stress in broilers. In addition, a growing body of literature suggests that the in ovo feeding of various nutrients can enhance the post-hatch thermotolerance of broilers. Therefore, we hypothesized that the supplementation of GABA during incubation might have positive effects in heat-stressed broilers. Chicks hatched from eggs were divided into three groups described as follows: chicks hatched from eggs incubated at normal temperature and then raised under thermoneutral temperature (CON); chicks hatched from eggs incubated at normal temperature but raised under cyclic heat stress (HS) (CON+HS); and chicks hatched from eggs injected with 60 mg of GABA dissolved in 0.6 mL of distilled water but raised under cyclic HS (G10+HS). The HS was applied between 28 and 31 days of age with ambient temperatures raised from 22 ± 1 °C to 33 ± 1 °C for 6 h daily. Compared to the CON group, average daily weight gain was significantly lower in the CON+HS but not in the G10+HS group. Feed intake was significantly decreased in both the CON+HS and G10+HS groups. Compared to the CON group, plasma corticosterone levels were significantly increased in the CON+HS group, but not the G10+HS group. Hepatic mRNA levels of the acetyl-CoA carboxylase gene (ACC) were significantly reduced in the G10+HS group compared to the CON group. In addition, positive Pearson correlation coefficients were found in mRNA levels between fatty acid synthase (FAS) and nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1) (r = 0.55, p < 0.05), NOX1 and NOX4 (r = 0.65, p < 0.01), and catalase (CAT) and superoxide dismutase (SOD) (r = 0.62, p < 0.05). Taken together, the results suggest that this study can serve as a basis for future work focusing on the in ovo feeding of GABA as a technique to combat heat stress in broilers.

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Section: Discussionmentioning

confidence: 99%

Effects of In Ovo Feeding of γ-Aminobutyric Acid on Growth Performances, Plasma Metabolites, and Antioxidant Status in Broilers Exposed to Cyclic Heat Stress

et al. 2021

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“…Neurodegenerative diseases including AD, Parkinson's disease, and Huntington's disease have threatened human health and the quality of life in elderly people (Ross & Poirier, ). Advancement of industrialization (Vijaya Abinaya et al, ), lack of physical exercise, and Western diets trigger oxidative stress, which acts as a major risk factor for cognitive dysfunction and dementia in the elderly (Hillman, Erickson, & Kramer, ). Phytonutrients play a major role in the prevention of dementia (Kalaria et al, ).…”

Section: Discussionmentioning

confidence: 99%

Protective effects ofStachys sieboldiiMIQ extract in SK-N-SH cells and its memory ameliorative effect in mice

et al. 2017

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This work aims to evaluate the potential effect of Stachys sieboldii MIQ (SS) against oxidative stress induced by hydrogen peroxide (H2O2) in SK‐N‐SH cells and memory enhancement in ICR mice using the passive avoidance test. The effect of SS in cell proliferation was measured by BrdU incorporation assay with dosages of SS from 0 to 2 mg/mL. SS partially antagonized the effect of 150 μM H2O2 on cell proliferation. In vivo study, SS (100, 250, and 500 mg/kg) was administered orally to mice for 4 weeks. SS led to a significantly longer step‐through latency time compared to control mice. Memory enhancing effect of SS (500 mg/kg) was also observed in amnesia model, SS escalate the fear memory (p < .05), increase acetylcholine and choline acetyl transferase level in hippocampus and cortex than nontreated group. These results suggest that SS can be used to manage memory related disorders in animals. Practical applications Acetylcholine is a cholinergic neurotransmitter known for its various medicinal properties, reducing dementia, depression, cancer, inflammation, and is also required to build muscles in the human body. Hence, the development of a choline‐rich source is of great interest. SS is a good source for vitamins especially vitamin B complex, which is a major precursor for choline synthesis in human. Therefore, this study investigates the memory enhancement effects of Stachys sieboldii MIQ (SS), a choline‐rich plant, in SK‐N‐SH cells and an in vivo animal model. SK‐N‐SH cells and mice treated with SS exhibited memory ameliorative effects. This study sheds light on using plant‐based products as potential functional foods and nutraceuticals for cognition improvement. The results of this study could serve as a foundation for further research on SS extract as a source of choline and promotes the consumption of Stachys sieboldii on a large scale.

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“…TG and TC from liver tissue were analyzed using a previously described method (Vijaya Abinaya et al., ). Tissue was homogenized using chloroform: methanol solution (2:1) was vortexed and centrifuged.…”

Section: Methodsmentioning

confidence: 99%

Antiobesity Effects of Purple Perilla (Perilla frutescens var. acuta) on Adipocyte Differentiation and Mice Fed a High‐fat Diet

Thomas

Kim

Lee

et al. 2018

Journal of Food Science

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γ-amino butyric acid-enriched barley bran lowers adrenocorticotropic hormone and corticosterone levels in immobilized stressed rats

Cited by 8 publications

References 49 publications

Effects of In Ovo Feeding of γ-Aminobutyric Acid on Growth Performances, Plasma Metabolites, and Antioxidant Status in Broilers Exposed to Cyclic Heat Stress

Effects of In Ovo Feeding of γ-Aminobutyric Acid on Growth Performances, Plasma Metabolites, and Antioxidant Status in Broilers Exposed to Cyclic Heat Stress

Protective effects ofStachys sieboldiiMIQ extract in SK-N-SH cells and its memory ameliorative effect in mice

Antiobesity Effects of Purple Perilla (Perilla frutescens var. acuta) on Adipocyte Differentiation and Mice Fed a High‐fat Diet

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