γ/δ T-Cell Lymphoma of the Thyroid Gland

T-cell Lymphoma of Thyroid Gland with Lennert Type of Morphology: A Case Report and Review of the Literature

“…Thyroid function tests and the clinical thyroid status of patients are found to be either euthyroid or hypothyroid goiter in all case reports [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Our patient was a case of sub-clinical goiter with a sudden onset of pressure symptoms.…”

“…B-cell lymphomas overwhelmingly outnumber their T-cell counterparts in thyroid gland, with only about twenty cases of TCL having been reported in the literature [2][3][4][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The first case of TCL of thyroid was reported in an English lady in 1977 [12].…”

“…In our case, clonality study by PCR was done in view of the atypical morphology, and it demonstrated positivity for TCR b gene rearrangement supporting the diagnosis of PTCL, NOS, of thyroid. Yamaguchi et al [13] have reported the only case of thyroid lymphoma with c/d gene rearrangement whereas the rest all tested were positive for a/b genotype.…”

“…Almost all primary thyroid lymphomas turn out to be a non-Hodgkin lymphoma (NHL) of B-cell origin of either marginal zone lymphoma of mucosa associated lymphoid tissue (MALT) or diffuse large B-cell lymphoma (DLBCL) type [2][3][4][5]. T-cell lymphoma (TCL) in the thyroid gland is distinctly rare with about 20 cases having been reported so far in the literature [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Age range of these cases was between 34 and 86 years with a male to female ratio of 1.15:1.…”

“…Most of the reported cases showed a low grade behavior on follow up unlike the aggressive behavior seen in conventional TCL [3,9]. Microscopic morphology, in these cases, is variable showing most commonly a small lymphocytic infiltrate invading the thyroid follicles, also forming lymphoepithelial bodies in some cases [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Immunohistochemistry (IHC) of tumors in these cases has often revealed a predominant T-cell population with positivity for CD2, CD3 & CD5, with one case also reporting loss for CD7 [6].…”