γδ T-Cell Lymphoma of the Skin

Toro, Jorge R.; Beaty, Micheal; Sorbara, Lynn; Turner, Maria L.; White, Jeffrey T.; Kingma, Douglas W.; Jaffe, Elaine S.

doi:10.1001/archderm.136.8.1024

Cited by 138 publications

(39 citation statements)

References 38 publications

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“…Although hepatosplenic gamma delta T-cell lymphoma is the prototypic gamma delta T-cell neoplasm, mucocutaneous gamma delta T-cell lymphoma and gamma delta T-cell LGL leukemia have been described (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). With the exception of gamma delta T-cell LGL leukemia, these malignancies have a poor prognosis and require aggressive chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…All cutaneous gamma delta T-cell lymphomas were negative for CD7 (69% positive in hepatosplenic gamma delta T-cell lymphomas and 100% positive in gamma delta T-cell LGL leukemias), CD16 (58% positive in hepatosplenic gamma delta T-cell lymphomas and 86% positive in gamma delta T-cell LGL leukemias), and CD57 (100% negative in hepatosplenic gamma delta T-cell lymphomas and 57% positive in gamma delta T-cell LGL leukemias) (4,(6)(7)(9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

“…Mucocutaneous gamma delta T-cell lymphomas also have been described and generally involve mucosa and skin (6)(7)(8)(9)(10)(11)(12). These anatomic locations are normal distribution sites for gamma delta T-cell lymphocytes and as such suggest the possible role of chronic antigen exposure in the pathogenesis of these tissue-restricted gamma delta T-cell lymphomas (6).…”

mentioning

confidence: 99%

“…The mucocutaneous gamma delta T cell lymphomas have varied clinical presentations, including subcutaneous panniculitis-like gamma delta T-cell lymphoma, mycosis fungoid-like cutaneous gamma delta T-cell lymphoma, nasal NK/T gamma delta T-cell lymphoma, and enteropathy type gamma delta T-cell lymphoma. Mucocutaneous gamma delta T-cell lymphomas differ from their alpha beta T-cell counterparts in that they are more aggressive neoplasms and survival is poor in comparison (6)(7)(8)(9)(10)(11)(12). Hemophagocytic syndrome and significant cytopenias can occur.…”

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confidence: 99%

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Flow cytometric immunophenotypic profiles of mature gamma delta T‐cell malignancies involving peripheral blood and bone marrow

Ahmad

Kingma

Jaffe

et al. 2005

Cytometry Part B Clinical

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Background: In this study we compared clinical findings with flow cytometric immunophenotypic results in a series of patients with aggressive and indolent gamma delta T-cell malignancies with peripheral blood and/or bone marrow involvement.Methods: Gamma delta T-cell malignancies were detected based on flow cytometric demonstration of an abnormal T-cell population staining positive with T-cell receptor gamma delta and confirmed by morphologic and clinical reviews. Clinical data were obtained through chart review and discussion with the patients' physicians.Results: Blood or bone marrow involvement was present in all patients. Hepatosplenic and cutaneous gamma delta T-cell lymphomas had an aggressive clinical course, whereas the gamma delta T-cell large granular lymphocyte (LGL) leukemias had an indolent course. Expressions of CD5, CD8, CD16, and CD57 differed in gamma delta T-cell LGL leukemia compared with hepatosplenic and cutaneous gamma delta T-cell lymphomas.Conclusions: Gamma delta T-cell malignancies have a poor prognosis with the exception of gamma delta T-cell LGL leukemia (indolent process). Because CD57 expression is specific for gamma delta T-cell LGL leukemias, expression of this antigen may be associated with a more indolent clinical course. Because cutaneous gamma delta T-cell lymphoma can present with peripheral blood involvement, flow cytometric evaluation of peripheral blood is important in staging these patients. Published 2005 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Flow cytometric immunophenotypic profiles of mature gamma delta T‐cell malignancies involving peripheral blood and bone marrow

Ahmad

Kingma

Jaffe

et al. 2005

Cytometry Part B Clinical

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“…Thus, CD8+ positivity alone has no prognostic value. Primary cutaneous γ/δ T-cell lymphoma is a lymphoma composed of a clonal proliferation of mature activated γ/δ T-cells, also showing an aggressive clinical course [15, 16]. In these cases, too, marked epidermal infiltration may occur.…”

Section: Discussionmentioning

confidence: 99%

Fatal CD8+ Epidermotropic Cytotoxic Primary Cutaneous T-Cell Lymphoma with Multiorgan Involvement

et al. 2005

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A 70-year-old woman presented with a 3-month history of two ulcerated erythematous-violaceous nodular lesions over the nose and forehead, respectively. The patient’s history included a similar cutaneous nodule on the glabella diagnosed as pseudolymphoma 2 years ago.At that time, despite the diagnosis of a benign disease, an adequate staging was performed, ruling out any extracutaneous involvement. During hospitalization, multiple purpuric papules developed over the abdomen, and the disease spread to mediastinal lymph nodes, lungs and the central nervous system. Based on the histologic, immunophenotypic and molecular biology findings, a diagnosis of CD8+ epidermotropic cytotoxic primary cutaneous T-cell lymphoma was made. Secondary skin involvement by a CD8+ extracutaneous T-cell lymphoma could not be excluded with certainty, but seemed to be unlikely because of the negativity of the initial workup. The patient died from complications of right femoral artery thrombosis before starting specific polychemotherapy 21 months after onset of the disease. Among primary cutaneous T-cell lymphomas, the CD8+ epidermotropic cytotoxic subset comprises rare, highly aggressive forms characterized by metastatic spread to unusual sites such as the oral cavity, lungs, testis and the central nervous system but usually not to the lymph nodes. These cases seem to be distinct from mycosis fungoides with CD8+ phenotype, which shows a nonaggressive clinical behavior.

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Cutaneous γδ T-Cell Lymphomas—How and Why Should They Be Recognized?

Kadin¹

2000

Arch Dermatol

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γδ T-Cell Lymphoma of the Skin

Cited by 138 publications

References 38 publications

Flow cytometric immunophenotypic profiles of mature gamma delta T‐cell malignancies involving peripheral blood and bone marrow

Flow cytometric immunophenotypic profiles of mature gamma delta T‐cell malignancies involving peripheral blood and bone marrow

Fatal CD8+ Epidermotropic Cytotoxic Primary Cutaneous T-Cell Lymphoma with Multiorgan Involvement

Cutaneous γδ T-Cell Lymphomas—How and Why Should They Be Recognized?

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