Вплив «Ампролінсилу» І Бровітакокциду На Активність Ензимів Сироватки Крові За Еймеріозної Інвазії

Gutyj, B. V.; Hariv, I.; Gunchak, V.; Sobolta, A.; Pryima, O. B.; Iesina, E.

doi:10.15421/nvlvet8310

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Obviously, in this process, there were functional changes in the liver of investigated animals. In particular, increased activity of the AsAT enzyme indicates a violation of the integrity of the liver cells (Gutyj et al, 2018). This is especially true in animals of the second experimental group, as evidenced by an increase in GGT activity, which reflects the state of the liver and hepatobiliary tract.…”

Section: Indexesmentioning

confidence: 95%

Influence of HammecoTox and Zeolitis on morphological and biochemical indicators of rat's blood under conditions of experimental fumonisin toxicosis

Brezvyn

Guta

2018

Ukr. Jour. of Vet. and Agr. Sci.

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In the article the peculiarities of the influence of fodder additives HammecoTox and Zeolit on the organism of rats under conditions of experimental chronic fumonisin toxicosis are given. The research was carried out under vivarium of State Scientific-Research Control Institute of Veterinary Medicinal Products and Feed Additives. In the experiment, 40 rats of body weight 165–170 g. were used. 4 groups were formed. First group of animals was control, in experimental II, III, and IV groups of animals chronic fumonisin toxicosis was reproduced. Rats were injected intragastrically daily of 90 mg of fumonisin per animal. After the manifestation of clinical signs of fumonisin toxicosis on the 21st day, animals of groups ІІІ-ІV began to feed fodder additives, respectively, rats from group III – HammecoTox, IV – Zeolit. After injection of fumonisin to experimental rats, the morpho-functional state of animals has been gradually changing since the first days. Clinical picture of fumonisin toxicosis in experimental rats at day 14 was manifested by dermo-necrotic effect, it was observed redness and formation of crust on visible mucous membranes, nose, showed swelling and redness of the forelocks. After the analysis of the obtained results of hematological researches on the 14th day in rats of group II under the conditions of experimental fumonisin toxicosis, was revealed a probable increase in the number of leukocytes, was established a tendency for growth, the number of eosinophils, segmental neutrophils, as well as a decrease in the number of lymphocytes, monocytes, compared with the control group. In the analysis of leukograms was noted a tendency to shift the nucleus to the left. These results indicated the presence of inflammatory processes and reduced immune protection of the organism of animals in general. After using of feed additives of HammecoTox and Zeolit under conditions of fumonisin toxicosis, of particular note is the stabilization of hematological parameters, the content of hematocrit, the number of leukocytes, the increase in the content of eosinophils and lymphocytes, which reflects the activation of hematopoiesis in the organism of experimental animals and its protective factors. An increase in the urea content in these groups indicates the recovery of urea-synthesis and urea-excretory liver function. In general, for the period of the conducted searches, the effectiveness of both feed additives in the experimental fumonisin toxicosis has been established. However, it should be noted that more active processes of normalizing the clinical condition of experimental rats when using HammecoTox, which is due to the complex influence of the means on the organism of animals.

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Section: Indexesmentioning

confidence: 95%

Influence of HammecoTox and Zeolitis on morphological and biochemical indicators of rat's blood under conditions of experimental fumonisin toxicosis

Brezvyn

Guta

2018

Ukr. Jour. of Vet. and Agr. Sci.

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“…Крім того, плоди розторопші плямистої містять вітаміни (А, Е, К), мікроелементи (К, Са, Мg, Сu, Zn, Fe), жирні кислоти (олеїнову, ліноленову, пальмітинову, стеаринову), що значно розширюють і підвищують фармакологічну дію препарату. Проаналізувавши повідомлення вітчизняних і зарубіжних дослідників (Hikino et al, 1984;Zhao & Agarwan, 1999;Batakov, 2001;Chekman et al, 2014;Hariv & Gutyj, 2016; ми розробили новий протиеймеріозний препарат "Ампролінсил", який містить ампроліуму хлористоводневого 12,5 г і порошок плодів розторопші плямистої до 100 г, в якому знаходяться природні вітаміни А, К, Е, групи В і мікроелементи: Купруму, Ферруму, Кобальту та інші, що значно розширюють і підвищують фармакологічну дію препарату "Ампролінсил" (Gutyj et al, 2018). При застосуванні цього високоефективного протиеймеріозного препарату можна досягти високої терапевтичної ефективності за лікування індичат при еймеріозній інвазії і забезпечити високий імунний стан в організмі в після лікувальний період.…”

Section: вступunclassified

Effect of “Amprolinsyl” and “Amprolium 22%” on morphological indices of blood of turkeys for eumeria invasion

et al. 2019

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The article gives data on the influence of Amprolinsyl and Amprolium 22% on morphological parameters of blood after eumirioic invasion. It has been shown that after application of amprolium 22% for the treatment of turkeys infected with eumeria invasion, gradual normalization of hematological parameters of blood begins. Thus, at the 3rd day of treatment, the number of red blood cells increased, but remained 25.1% lower, and the hemoglobin level increased, but remained at 16.3% lower, compared with clinically healthy poultry. During this period, within the limits of normal values was the value of the color index, the mass of hemoglobin in the erythrocyte and the value of hematocrit. The obtained results indicate a gradual normalization of the erythropoietic function of the bone marrow. However, the large average volume of one erythrocyte is 1.12 ± 0.07 μm against 0.96 ± 0.03 μm³ in the control, and the decrease in the average concentration of hemoglobin in one erythrocyte by 13.3% against the norm indicates an incomplete recovery of the erythropoietic bone marrow function. At day 5 of treatment with amprolium, 22% of red blood cells and hemoglobin levels increased but still remained below physiological values by 12.3% and 6.8%, respectively, compared to control. At the 10th day of the experiment, restoration of hematopoietic function of the bone marrow was observed on physiological values of erythrocytes and hemoglobin content of the blood, as well as blood leukogram. In the treatment of turkeys with "Amprolisyl", at the 5th day, the hematopoietic function of the bone marrow completely normalized, as indicated by the number of red blood cells, hemoglobin content and red blood cell index values. It is known that the values of red blood cells, namely the volume of erythrocytes, the mass and concentration of hemoglobin in them, and the color index objectively reflect the state of hematopoietic function of the bone marrow. The results of our studies indicate that in the turkey infected with imeiriosis and treated with amprolium 22%, clinical recovery occurs at day 5, and the hematopoietic function of the bone marrow is restored spontaneously in 5 days after recovery. In the treatment of turkeys with Amprolinsyl, the restoration of morphological parameters, the normalization of white blood cell leukemogram and the clinical recovery of turkeys arose on the fifth day of treatment. Thus, due to the fact that Amporolinsyl, in addition to the active ingredient, contains sparse fruit of thistle spots, which contain high levels of vitamins A and K, and trace elements – Ferum, Kuprum and Cobalt, which are directly involved in hemopoiesis, therefore, the restoration of hematopoietic function of the bone marrow comes much faster than with the application of amprolium itself 22%.

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“…Вони переносять аміногрупи від аспарагінової кислоти (АсАТ) та аланіну (АлАТ) на альфакетоглутарову кислоту. Обидва ферменти локалізуються у цитоплазмі клітин (АсАТ також у мітохондріях) (Yaremko and Pelenio, 2016;Gutyj et al, 2018). Тому при пошкодженні тканин активність цих ферментів у сироватці крові підвищується.…”

Section: результати та їх обговоренняunclassified

Influence of cryptosporidiosis agent on biochemical and immunological parameters of blood of calves

Zhurenko¹,

Журенко²

2018

SMLNUVMB

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Cows, young cattle and calves of black-and-bark breeds, spontaneously affected by the causative agent Cryptosporidium parvum, were selected for the research. Blood for research was taken from calves in the morning before feeding from the jugular vein. Biochemical parameters of blood serum were determined using a biochemical analyzer of the closed type. Changes in the activity of serum enzymes in the initial stages of the disease are not specific, they indicate a compensatory reaction of liver cells and biliary tract. Effect of Cryptosporidium in calves body accompanied by severe disorders that affect the metabolism of proteins, carbohydrates and enzymes. These changes lead to structural changes in the organs at the cellular level. Serum infested animals significantly reduced total protein content of 25.5% (P < 0.001), albumin – by 14.6% (P < 0.01), the concentration of glucose in – 21.2% (P < 0.01), carotene content – 12.6% (P < 0.05), the level of calcium and phosphorus – 17.5 and 18% (P < 0.05), respectively, and increased total bilirubin content by 23% (P < 0.001), indicating significant violations of the protein synthesis and detoxification processes in the liver and the tension in the metabolism of their body. Reduced glucose concentration in blood serum is due to the fact that in the body of sick animals there have been increased costs for maintaining the energy needs of its own organism. In conducting studies for 35 days in animals in the experimental group noted an increase in the concentration of circulating immune complexes by 10.5% relative to control. Increasing the concentration of circulating immune complexes in serum of calves, patients with cryptosporidiosis, indicates the presence of specific interaction antigen-antibody and decrease the activity of the humoral link of the immune system. In the determination of immunosuppressive proteins – serum cords in serum of calves, it was found that at 7, 14 days their concentration was within the physiological limits. Increasing the concentration of circulating immune complexes in serum of calves, patients with cryptosporidiosis, indicates the presence of specific interaction antigen-antibody and decrease the activity of the humoral link of the immune system.

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Вплив «Ампролінсилу» І Бровітакокциду На Активність Ензимів Сироватки Крові За Еймеріозної Інвазії

Cited by 3 publications

References 9 publications

Influence of HammecoTox and Zeolitis on morphological and biochemical indicators of rat's blood under conditions of experimental fumonisin toxicosis

Influence of HammecoTox and Zeolitis on morphological and biochemical indicators of rat's blood under conditions of experimental fumonisin toxicosis

Effect of “Amprolinsyl” and “Amprolium 22%” on morphological indices of blood of turkeys for eumeria invasion

Influence of cryptosporidiosis agent on biochemical and immunological parameters of blood of calves

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