Дослідження Зв’язку Поліморфізмів Генів ACE, AGT Та FGB Із Ризиком Раннього Розвитку Ішемічного Інсульту Атеротромботичного Підтипу В Популяції Осіб, Які Проживають На Території України

Tsymbalyuk, V. І.; Vasilyeva, I. G.; Kostiuk, Mykhaylo; Chopik, N. G.; Galanta, O. S.; Tsyubko, O. I.; Oleksenko, N. P.; Dmitrenco, A.B.; Makarova, T. A.; Snitsar, N. D.

doi:10.22141/2224-0713.8.86.2016.90907

Cited by 2 publications

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“…The М235Т (rs699) polymorphism is a replacement of methionine with threonine at position 235 of the peptide chain, which is caused by a point replacement of thymine with cytosine at position 704 of the AGT gene (Т704С). 34 The polymorphic variant included in this study was the single-nucleotide replacement of thymine with cytosine at position 704 of the second exon of the angiotensinogen gene, which is leading to the Met → Thr change at position 235 of the final product (М235Т).…”

Section: Discussionmentioning

confidence: 99%

AGT M235T Polymorphism and Arterial Hypertension in Patients with Chronic Obstructive Pulmonary Disease

Maksiv¹,

Krynytska²

2021

Bangladesh Med Res Counc Bull

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Background: Chronic obstructive pulmonary disease (COPD) represents an important public health challenge. It is a major cause of chronic morbidity and mortality throughout the world. Arterial hypertension (AH) is considered one of the principal COPD-associated comorbidities. Objective: The study was aimed to assess the role of angiotensinogen (AGT) gene polymorphism in occurrence of AH in patients with COPD. Methods: The study was conducted among 96 patients of them, Group 1 (25 individuals with COPD), Group 2 (23 individuals with AH), Group 3 (28 individuals with COPD and AH). The control group consisted of the 20 healthy subjects. I/D genotypes of AGT were determined by polymerase chain reaction amplification. Plasma AGT activity was determined photometrically by a commercially available kit. Results: The results of the study have not demonstrated any significant impact of alleles of AGT genes on occurrence of such disease as COPD, AH and combinations thereof. However, analysis of odds ratio has demonstrated the presence of a trend towards a protective role of the M allele of the AGT gene concerning occurrence of COPD, AH and their combinations (OR=0.90, OR=0.71 and OR=0.56, respectively). At the same time, the presence of the T allele of the AGT gene may increase the risk for occurrence of the above mentioned disease (OR=1.11, OR=1.4 and OR=1.79, respectively). Conclusion: The study suggests that the presence of Т allele of the AGT gene at position 235 of the peptide chain both in homozygous and heterozygous state may increase the risk for AH in patients with COPD. Bangladesh Med Res Counc Bull 2020; 46(3): 176-183

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Section: Discussionmentioning

confidence: 99%

AGT M235T Polymorphism and Arterial Hypertension in Patients with Chronic Obstructive Pulmonary Disease

Maksiv¹,

Krynytska²

2021

Bangladesh Med Res Counc Bull

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“…The Т174М (rs4762) polymorphism is characterized by a replacement of threonine with methionine at position 174 in the peptide chain, which is caused by a point replacement of cytosine with thymine at position 521 of the AGT gene (C521T). The М235Т (rs699) polymorphism is a replacement of methionine with threonine at position 235 of the peptide chain, which is caused by a point replacement of thymine with cytosine at position 704 of the AGT gene (Т704С) (35,36). .…”

Section: Discussionmentioning

confidence: 99%

Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism

2019

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BackgroundChronic obstructive pulmonary disease (COPD) continues to cause a heavy health and economic burden in the Europe and around the world. Arterial hypertension (AH) is considered as one of the principal COPD-associated comorbidi-ties. However, no data for association between gene polymorphism and AH in patients with COPD in Ukraine have ever been internationally published. We assessed the genotype and allele frequencies of angiotensinogen (AGT) M235T polymorphisms in patients with COPD and comorbid AH.MethodsThe study group consisted of 96 patients: Group 1 (25 individuals with COPD), Group 2 (23 individuals with AH) and Group 3 (28 individuals with COPD and AH). The control group consisted of 20 healthy subjects. M/T genotypes of AGT were determined by polymerase chain reaction amplification.ResultsThe results of the study have not demonstrated any significant impact of alleles of AGT genes on the occurrence of diseases such as COPD, AH and combinations thereof. However, analysis of odds ratio has demonstrated the presence of a trend towards a protective role of the M allele of the AGT gene concerning occurrence of COPD, AH and their combinations. At the same time, the presence of the T allele of the AGT gene may increase the risk for occurrence of the above-mentioned diseases.ConclusionsThe study that we have conducted suggests that the presence of T allele of the AGT gene at position 235 of the peptide chain both in homozygous and heterozygous states may increase the risk for AH in patients with COPD.

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Cited by 2 publications

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AGT M235T Polymorphism and Arterial Hypertension in Patients with Chronic Obstructive Pulmonary Disease

AGT M235T Polymorphism and Arterial Hypertension in Patients with Chronic Obstructive Pulmonary Disease

Association between arterial hypertension and chronic obstructive pulmonary disease: role of AGT gene polymorphism

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